The students get experience to the field of computational chemistry/medicinal chemistry and tο the QSAR analytical studies as well as with the chemical-molecular mechanism of action of natural bioactive molecules and chemometrics.
2) Rekka E. The aim of this course is to help the students understand oxygen toxicity, generation and activity of free radicals, as well as the critical evaluation of the above in the design and development of molecules capable to protect the organism from radical attack.
3) Kourounakis P.N. Aim of the course is to present some of the current approaches in the process of drug development, from the design and discovery of lead compound, pharmacophore structure, drug optimization, to clinical studies, pharmacovigilance or withdrawal of some drugs, that lead to drug design. Examples are presented explaining the principles of successful drug design.
Course Content (Syllabus)
1) Hadjipavlou-Litina D.
Introduction to the use of computer in topics concerning applications in medicinal chemistry. Relationships between structure and physicochemical properties and bioogical activity (SAR).Quantitative structure -activity relationships. (QSAR)Computational medicinal Chemistry.
2) Rekka E. The international scientific interest in the effect of free radicals on the organism has increased recently, mainly due to the elucidation of the significance of free radical reactions on chemical processes in the biologic systems and the mechanism of action of many xenobiotics. Based on this knowledge, the significance of free radical reactions on the living systems and the effect of drugs and other xenobiotics on them are presented and evaluated. The design of drugs able to control free radical processes is studied.
3) Kourounakis P.N. Methods for the application of the three basic approaches for the rational design of new pharmacomolecules, i.e. pathobiochemistry of the desease, chemical mechanism of drug action and drug metabolism, are studied. It is explained that new or improved drugs are needed for pathologic conditions such as inflammation, hyperlipidemia and atherosclerosis, neuronal degeneration, mainly cognition disorders, and biologic stress. Some examples are given for the synthesis and mechanism of action of drugs targeting conditions like anxiety and depression.
The students are working a project by themselves, searching the literature and finding data(derivatives and their biological results) analyzing them using several computational techniques and driving equations correlating structure with activity. They discuss the results and they try to explain them.
2) Rekka E. The evaluation of the students is achieved by written examinations. It is based on questions that the students are asked to answer depending on their knowledge obtained from the lectures as well as on the critical thinking and ability to combine, evaluate and handle the acquired knowledge and information.
The grade is evenly allocated to the teachers, according to the programme of their lectures. The duration of the examination is 3 hours. The examination at the end of the semester is performed at dates, time and place arranged by the department.
3) Kourounakis P.N. The evaluation of knowledge and capabilities acquired by the students is achieved by written examinations and by written essays. It is based on questions that the students are asked to answer depending on their knowledge obtained from the lectures as well as on the critical thinking and ability to combine, evaluate and handle the acquired knowledge and information. The grade is evenly allocated to the teachers, according to the programme of their lectures. The duration of the examination is 3 hours. The examination at the end of the semester is performed at dates, time and place arranged by the department.