Learning Outcomes
Upon successfully completing the course students will have acquired a good understanding of the capabilities and the limits of Pharmacogenomics and other "-omics"in the context of perosnalized therapy. They will have also acquired the ability to evaluate the clinical utility of pharmacogenomic/pharmacogenetic data in the context of clinical practice and/or designing of clinical studies. Finally they will have acquired the ability to design pharmacogenomic/pharmacogenetic Research.
Course Content (Syllabus)
Genetic diversity, evolution, and drugs
The genetics of adverse reactions
Basic principles of pharmacogenetics/ pharmacogenomi
Pharmacogenomics and anticancer drugs
Genotyping methods and pharmacogenetic tests
Pharmacogenomics and pediatric drugs
Pharmacogenomic data bases
Pharmacoepigenomics
Pharmacoproteomics
Pharmacometabol(n)omics
Ethical considerations and legal requirements in -omics
Practical: Interpretation of a pharmacogenomic test
Practical: Planning/ ordering a pharmacogenomic test
Keywords
Pharmacogenomics, Pharmacogenetics, Epigenomics, Proteomics, Metabolomics, Individualized therapy
Additional bibliography for study
Φαρμακογονιδιωματική και πρωτεϊνωματική. Τα εργαλεία της εξατομικευμένης ιατρικής. S.H.Y. Wong, M.W. Linder, R. Valdes Jr. Επιμέλεια Γ.Π. Πατρινός, Σ. Μπουκουβάλα. Επιστημονικές Εκδόσεις Παρισιάνου. 2010
Principles of Pharmacogenetics and Pharmacogenomics. R.B. Altman, D. Flockhart, D.B. Goldstein. Cambridge University Press 2012