The study of methodology (general issues) and special issues of organic synthesis from the synthetic point of view. Application of spectroscopic methods (MS, IR, NMR) for the elucidation of organic compound's structure.There are specific syntheses in the laboratory session. The knowledge of general Organic Chemistry is necessary.
Course Content (Syllabus)
Theory:Synthetic methodology: Retrosynthetic analysis. Functional group reactions. Synthone. Protection of functional groups. Elucidation of the structure of organic compounds by the use of spectroscopic methods (MS, IR, NMR).
Laboratory courses: Multistep syntheses of organic compounds. Protective groups. Stereoselective syntheses. Determination of the structure of organic compounds.
Retrosynthetic analysis, Protective groups, Oxidations, reductions, enolates, synthons, organometallic compounds, Structure elucidation of organic compounds by spectroscopic methods (MS, IR, NMR).
Course Bibliography (Eudoxus)
- ΣΥΝΘΕΤΙΚΗ ΟΡΓΑΝΙΚΗ ΧΗΜΕΙΑ, Ε. Μαλαμίδου-Ξενικάκη, Σ. Σπυρούδης, Εκδόσεις Άγις-Σάββας Δ. Γαρταγάνης, Θεσσαλονίκη, 2012.
Additional bibliography for study
- «ADVANCED ORGANIC CHEMISTRY, Reactions, Mechanisms, and Structure, Fourth Edition», J. March, Wiley-Interscience Publication, John Wiley & Sons Inc., New York, 1992.
- "ADVANCED ORGANIC CHEMISTRY", Part A & B, Second Edition, F. A. Carey, R. J. Sundberg, Plenum Press, New York, 1984.