Pharmaceutical Chemistry

Course Information
TitleΦΑΡΜΑΚΕΥΤΙΚΗ ΧΗΜΕΙΑ / Pharmaceutical Chemistry
Cycle / Level1st / Undergraduate
Teaching PeriodSpring
Course ID40000969

Class Information
Academic Year2018 – 2019
Class PeriodSpring
Faculty Instructors
Class ID
Course Type 2016-2020
  • General Knowledge
Course Type 2011-2015
General Foundation
Mode of Delivery
  • Face to face
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
This course is an introductory tool to the Medicinal Chemistry for the students of chemistry Department. They will get benefits from Synthetic methods for the synthesis of different classes of drugs as well as their structure-activity relationships, drug design, the role of physicochemical parameters and mechanism of action.
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Adapt to new situations
  • Make decisions
  • Work autonomously
  • Work in an interdisciplinary team
  • Design and manage projects
  • Respect natural environment
  • Be critical and self-critical
  • Advance free, creative and causative thinking
Course Content (Syllabus)
1)Demopoulos V. a) Stereochemical effects influencing biological activity (the role of optical, geometrical isomerization in the biological activity,the role of conformation, isosteres, isosterism. 2) Geronikaki A. Introduction to hormones.Synthesis , quanlitative and quantitative control, structure-activity relationships of corticosteroids Antagonist of hormones. Metabolism and mechanism of action. Role in the organism . The same for vitamines with antioxidant activity (ascorbic acid and tocoferoles). 3)Hadjipavlou-Litina D. Drug design, synthetic strategy, isolation, analysis, structures identification, molecular mechanism of action, structure activity relationships, selectivity, pharmacochemical aspects for representatitive drugs eg cholinergics, adrenergics, inhibitors of acetylcholinesterase. 4) Rekka E. This course briefly analyses synthetic routes, physical, chemical, biological properties, molecular mechanism of action, therapeutic applications of selected drugs acting on the central nervous system (general anesthetics, anxiolytics, antidepressants, opioid analgesics). 5) Papagiannopoulou D. Properties of diagnostic and therapeutic radionuclides. Methods of preparation and properties of the most common radiopharmaceuticals for the imaging of brain, myocardial, renal perfusion, as well as of targeted radiopharmaceuticals for bone, thyroid and cancer imaging/therapy are discussed.
hormons, corticosteroides, vitamines, ascorbic asid, tocoferoles
Educational Material Types
  • Notes
  • Slide presentations
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Laboratory Teaching
  • Use of ICT in Communication with Students
Powerpoint presentation is used in the lectures Notes in the form of powerpoint slides are provided by the course instructor. E-mail correspondence
Course Organization
Student Assessment
Examination of the course (grade ≥5 ) by a final written examination at the end of the semester. Τhe evaluation process is based on questions that the students are asked to answer based on their knowledge obtained from the lectures as well as on the critical thinking and ability to combine, evaluate and handle the acquired knowledge and information. The duration of the examination is 3 hours. The examination at the end of the semester is performed at dates, time and place arranged by the department. During the laboratory work, students hand over a report of their results and are evaluated. At the end of the laboratory work, there is a written examination on this. Successful termination of the laboratory course permits their participation to the final examination. At the examination of the course, each tutor gives out separate exam forms. To compute the final grade, the grade given by each tutor is weighted proportionately to the number of hours he/she has taught. Final grade is calculated by addition of the course exam grade (90%) and the lab exam grade (10%). Example: Supposing a course, where 60% of the hours are taught by tutor A and 40% by tutor B, the final grade is calculated by the following formula: F.G.= 0.9(a+b) +0.1c, Where, a the grade given by tutor A (in a scale of 0-6), b the grade given by tutor B (in a scale of 0-4), c the lab exam grade.
Student Assessment methods
  • Written Exam with Short Answer Questions (Formative)
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