Through the course, students are expected to
• acquire current knowledge of basic concepts, principles and applications of modern science (bio)materials in chemical and biomedical engineering, getting accustomed to using scientific vocabulary and simple language.
• learn how proteins and cells can interact with various biomaterials, and be involved in host responses to implants, including toxicity and health effects.
• familiarize themselves with basic synthetic and fabrication strategies related to the creation of new biomaterials.
• develop their personal experimental skills in basic knowledge of advanced (bio)materials chemistry (3D printing of scaffolds and tissues)
• gain knowledge of basic characteristics of qualitative chemical experimental research in modern chemistry of (bio)materials and critically understand its role in chemical engineering and modern applications in hybrid technological (bio)materials.
• accrue basic skills on applications of modern biomechanical and genetic technology
Course Content (Syllabus)
Course contents cover the following units
1. Introduction to materials
a) General properties
b) Surfaces in functional biological materials
c) Role of water in biomaterials
2. Families of biomaterials (natural products, metals, alloys, polymers, hydrogels, hybrid materials, etc.)
3. Cellular exploration, biochemistry and biomedicine
4. Degradation of materials in a biological milieu
5. Applications of materials in medicine (artificial organs)
6. Tissue engineering (immuno-isolation, synthetic scaffolds, etc.)
7. Biomaterials in action (implants, biodevices, etc.)
Development of laboratory activities related intimately to biotechnology (e.g. staining) and bioinformatics technology linked to novel biomaterials research.
The class covers two main activities:
1. The theoretical part referring the aforementioned contents
2. The experimental part extending to two Laboratory periods during which famialiarization will be pursued with
a) the production of biological genetic material, and
b) bioinformatics search of a diverse class of materials (proteins, enzymes, RNA, DNA, etc.)
in relevance to biomaterials development.
(bio)materials, biotechnology, applications in modern medicine, interactions between hybrid materials and cellular surfaces
Course Bibliography (Eudoxus)
1. Biomaterials Science
An Introduction to Materials in Medicine, 2nd Edition
B. D. Ratner, A. S. Hoffman, F. J. Schoen, J. E. Lemons
Elsevier Academic Press, 2004
2. Genetic Engineering – A primer
Walter E. Hill
Taylor & Francis, 2002
J. Y Wong, J. D. Bronzino
CRC Press, Taylor & Francis, 2007
4. Fundamentals of Materials Science and Engineering
William D. Callister, Jr.
John Wiley & Sons, Inc., 2001
A Practical Guide to the Analysis of Genes and Proteins
A. D. Baxevanis, B.F.F. Ouellette
Wiley Interscience, 2001
6. Advanced Data Mining Technologies in Bioinformatics
Idea Group Publishing, 2006
7. Bioinformatics Algorithms
Techniques and Applications
I. I. Mǎndoiu, A. Zelikovsky
John Wiley & Sons, Inc., 2001