CHEMISTRY OF COMPOUNDS OF PHARMACEUTICAL INTEREST
| Title | ΧΗΜΕΙΑ ΕΝΩΣΕΩΝ ΦΑΡΜΑΚΕΥΤΙΚΟΥ ΕΝΔΙΑΦΕΡΟΝΤΟΣ / CHEMISTRY OF COMPOUNDS OF PHARMACEUTICAL INTEREST |
| Code | ΑΦ0001 |
| Faculty | Health Sciences |
| School | Pharmacy |
| Cycle / Level | 2nd / Postgraduate, 3rd / Doctorate |
| Teaching Period | Spring |
| Common | No |
| Status | Active |
| Course ID | 180000000 |
| Academic Year | 2018 – 2019 |
| Class Period | Winter |
| Faculty Instructors | |
| Weekly Hours | 3 |
| Class ID | 600133185
|
Course Type 2016-2020
- Scientific Area
Course Type 2011-2015
Specific Foundation / Core
Mode of Delivery
- Face to face
Digital Course Content
- e-Study Guide https://qa.auth.gr/en/class/1/600133185
- At the Website of the School: users.auth.gr/papagd/metaptyxiako
Language of Instruction
- Greek (Instruction, Examination)
Learning Outcomes
Aims of the course:
The objective of the present course is to establish an interactive approach in constructing new chemical entities in the frame of Medicinal Chemistry. It is addressing postgraduate Pharmacy students in the teaching cycle of their studies and, therefore, it is prerequisite for their scientific evolvement.
Skills:
The present course will establish the thesis that the postgraduate Pharmacy should be able to use the central principles of chemistry in order to understand the basic concepts which govern the preparation and usage of pharmacotherapeutic/pharmacodiagnostic molecules.
General Competences
- Apply knowledge in practice
- Retrieve, analyse and synthesise data and information, with the use of necessary technologies
- Adapt to new situations
- Make decisions
- Work autonomously
- Work in teams
- Work in an international context
- Work in an interdisciplinary team
- Generate new research ideas
- Design and manage projects
- Appreciate diversity and multiculturality
- Respect natural environment
- Demonstrate social, professional and ethical commitment and sensitivity to gender issues
- Be critical and self-critical
- Advance free, creative and causative thinking
Course Content (Syllabus)
General synthetic methods towards preparation of molecules of pharmaceutical interest. Utilization of classical and retrosynthetic methodologies. Study of chemical properties which are connected to the structure (analysis of chemically characteristic groups) of pharmacomolecules, in order to indentify, to quantitatively analyze and detect side products, as well as analysis of their pharmaceutical and biological properties. Examples of important pharmaceutical molecules (inhibitors of lipoxygenase, serineproteases,phospholipases, coumarines, metalloproteases) including radiopharmaceuticaqls as well.
Educational Material Types
- Notes
- Slide presentations
Use of Information and Communication Technologies
Use of ICT
- Use of ICT in Course Teaching
- Use of ICT in Communication with Students
Description
The lectures of the course are based either on the classical chalk and a blackboard method with occasional use of slides or power point. Communication and exchange of tutorial material is taking place via e-mail, while in the webpage users.auth.gr/papagd/metaptyxiako there are the notes of Dionysia Papagiannopoulou as well as the respective bibliography and the power point slides.
Course Organization
| Activities | Workload | ECTS | Individual | Teamwork | Erasmus |
|---|---|---|---|---|---|
| Lectures | 26 | 0.9 | ✓ | ||
| Reading Assigment | 13 | 0.4 | ✓ | ||
| Total | 39 | 1.3 |
Student Assessment
Description
The evaluation of knowledge and skills which have been acquitted by the students from the course work is attested via written homework involving solution of composite synthetic problems which are conducted in a fixed date. The students are asked to answer based on their knowledge obtained from the lectures as well as on the critical thinking and ability to combine, evaluate and handle the acquired knowledge and information.
Student Assessment methods
- Written Exam with Short Answer Questions (Summative)
- Written Assignment (Summative)
Bibliography
Additional bibliography for study
1) Βασίλης Δημόπουλος
Stuart Warren & Paul Wyatt «Organic Synthesis: The Disconnection Approach», 2009, ISBN-13: 978-047071236
2) Διονυσία Παπαγιαννοπούλου
Adam, M. J.; Wilbur, S. D. Radiohalogens for imaging and therapy. Chem. Soc. Rev., 2005, 34, 153–163.
Wilbur, S. D. Radiohalogenation of Proteins: An Overview of Radionuclides, Labeling Methods, and Reagents for Conjugate Labeling. Bioconj. Chem., 1992, 3(6), 433-470
Elsinga, P. H. Radiopharmaceutical chemistry for positron emission tomography. Methods, 2002, 27, 208–217
3) Δήμητρα Χατζηπαύλου-Λίτινα
Medicinal Research Reviews
Mini reviews in Medicinal Chemistry
Current Medicinal Chemistry
Current Pharmaceutical Design
Current Enzyme Inhibition
Last Update
30-06-2013
