Learning Outcomes
The course's objective is to promote the understanding of the physicochemical principles of pharmaceutics, and the interrelations between the physical properties of the raw materials and those of the pharmaceutical formulations and final dosage forms. Additionally, the experimental methods used in the physicochemical characterization of pharmaceutical materials are thoroughly discussed.
Course Content (Syllabus)
Solid state properties (crystal structure, polymorphism, solvate formation). Solid phase transitions and their consequences on pharmaceutical product formulation.
Methods of physicochemical characterization of pharmaceutical materials: optical microscopy, thermal analysis, vibrational spectroscopy, X-ray diffraction, solid state NMR spectroscopy.
Additional bibliography for study
Adeyeye, M., Brittain, H., Preformulation in Solid Dosage Form Development (Drugs and the Pharmaceutical Sciences), Informa Healthcare, 2008.
Brittain, H. Physical Characterization of Pharmaceutical Solids (Drugs and the Pharmaceutical Sciences), Informa Healhcare, 1995.
Brittain, H., Polymorphism in Pharmaceutical Solids, Second Edition (Drugs and the Pharmaceutical Sciences), Informa Healhcare, 2009.
Byrn, S. Solid-state Chemistry of Drugs, SSCI Inc., 1999.
Hilfiker, R., Polymorphism in the pharmaceutical industry, Wiley-VCH, 2006.
Kuhnert-Brandstätter, M. Thermomicroscopy in the Analysis of Pharmaceuticals, Pegamon Press, Oxford, 1974.