Aims of the course:
The objective of the present course is to establish an interactive approach in preparing new chemical entities via the retrosynthetic approach. It is addressing postgraduate Pharmacy students in the teaching cycle of their studies and, therefore, it is prerequisite for their scientific evolvement.
The present course will establish the thesis that the postgraduate Pharmacy should be able to use the central principles of chemistry in order to understand the basic concepts of synthetic strategy. Synthetic strategy is something more than just organic synthesis – it teaches intellectual synthesis as well.
Course Content (Syllabus)
In this course the students are becoming familiar of the conception of synthon (i.e. structural unit, constitutive of a molecule, which is related to its putative synthetic handling), as a main “tool” for successfully solving synthetic problems through “retrosynthetic strategy” for the preparation of organic molecules of pharmacological interest. The used examples during the course’s lectures are molecules reported in the international pharmaceutical literature.