The main objective is the complete presentation of the influence offormulation factors on the therapeutic efficacy and safety of pharmaceutical products. Also, the influence of the roots of administration in combination with the physicochemical characteristics of the drugs, on the efficacy and safety fo the product.
Course Content (Syllabus)
Introductions-Definitions. Pharmacokinetic parameters and absorption, distribution, metabolism and excretion models. Bioavailability and bioequivalence of pharmaceutical products and drug substances. Route of the drug from the dosage form to the gastric fluids (instant and modified dosage forms, mechanisms, equations and ways to study drug release). Movement of dosage forms in the gastro-intestinal tract (anatomy and physiology of GI tract, biologic barriers and mechanisms of transport and absorption of medicines, physiologic and formulation factors that affect the bioavailability of per os administered pharmaceutical products). Routes of drug administration other than per os (oral cavity, skin, intra-muscular injection, rectum, nasal cavity, lungs etc.) The drug after arrival in the systemic circulation (distribution, protein binding and elimination). Excretion and drug metabolism (renal and hepatic clearance, hepatocholic excretion and enterohepatic circulation). First pass metabolism (factors that affect its appearance and consequences for the bioavailability of drugs). Dosage scheme for specific medicines and diseases.
Practical classes in pharmacokinetic simulations and calculation of pharmacokinetic parameters using computers and interactive software for self-teaching. Ιn vitro - in vivo correlation of pharmacokinetic behaviour of pharmaceutical products and drugs.