To introduce the students to the subject of quality control of pharmaceuticals and the physical, chemical, physicochemical and biological tests and assays used for their assessment.
To establish understanding of laboratory techniques for some of the major branches of pharmaceutical sciences.
To instruct the student on the preparation of laboratory reports, using appropriate statistical and mathematical calculations.
Course Content (Syllabus)
Introduction to quality control of pharmaceuticals. Methods of analysis (physical and physicochemical methods). Pharmaceutical technical procedures. Biological tests and assays. Pharmaceutical stability.
Laboratory practical: Decomposition of phenobarbital and salicylic acid in alkaline environment (orders of reactions, Arrhenius equation, activation energy). Quality control assays of tablets containing ampicillin and prednisolone (dissolution studies, analysis of drug content and weight uniformity).
Additional bibliography for study
1. Physical Pharmacy Fourth Edition, Ed. Al. Martin Lea & Febiger Philaddelphia, London 1993.
2. Pharmaceutics – the Science of Dosage Form Design, 2nd Edition, Churchill Livingstone, London 2002.
3. Drug Stability: Principles and practices Ed. C. T. Rodes and J.O. Cartensen, Marcel Dekker: New York. 1990.