CLINICAL PHARMACOKINETICS

Course Information
TitleΚΛΙΝΙΚΗ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΗ / CLINICAL PHARMACOKINETICS
Code79
FacultyHealth Sciences
SchoolPharmacy
Cycle / Level1st / Undergraduate
Teaching PeriodSpring
CommonNo
StatusActive
Course ID180000099

Programme of Study: Programme of Studies 2008-

Registered students: 267
OrientationAttendance TypeSemesterYearECTS
CoreCompulsory Course845

Class Information
Academic Year2018 – 2019
Class PeriodSpring
Faculty Instructors
Weekly Hours5
Class ID
600137717
Type of the Course
  • Scientific Area
Course Category
Specific Foundation / Core
Mode of Delivery
  • Face to face
Digital Course Content
Erasmus
The course is also offered to exchange programme students.
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
Ioannis Niopas • The in-depth understanding of the basic pharmacokinetic concepts, processes (absorption, distribution, metabolism, excretion) and basic pharmacokinetic relationships. • The determination of the different pharmacokinetic parameters and the analysis of their effect on drug concentrations in plasma after single or multiple dosing. • The aacquiring of skills through solving representative pharmacokinetic exercises on the application of pharmacokinetic principles in clinical practice in order to overcome specific therapeutic problems. • The assessment of the suitability of dosage regimens and the design of dosage regimens in order to achieve therapeutic concentrations of the drug to the patient. • The analysis of clinically significant pharmacodynamic and pharmacokinetic drug interactions and how to manage them. Ioannis Vizirianakis The lectures and tutorials aim to assist pharmacy students in developing their capabilities to: a) assess and predict clinically relevant drug interactions; b) acquire knowledge on how drug delivery outcomes can be strengthened in healthcare; and c) develop practical skills as practitioners in order to improve drug efficacy and safety profiles in clinical practice. In order these targets to be achieved, specific teaching methodologies are applied: 1) lectures focusing on selected pharmacokinetics, pharmacodynamics, pharmacogenomics and personalized medicine concepts; 2) discussions of specific clinical drug interaction case studies within the frame of evidence-based medicine; and 3) tutorials for specific drug dosage scheme data evaluation by implementing the “Simcyp-Population Based Pharmacokinetic Modelling and Simulation» platform (academic license agreement since 2009).
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Make decisions
  • Work in teams
  • Work in an international context
  • Work in an interdisciplinary team
  • Generate new research ideas
  • Demonstrate social, professional and ethical commitment and sensitivity to gender issues
  • Be critical and self-critical
  • Advance free, creative and causative thinking
Course Content (Syllabus)
Ioannis Niopas Introduction to the basic concepts of pharmacokinetics. Absorption of drugs. Distribution of drugs. Binding of drugs with plasma proteins and tissues. Clearance of drugs. Pharmacokinetics of rapid intravenous injection (bolus). Pharmacokinetics of intravenous drug infusion. Pharmacokinetics of extravascular drug administration. Multiple dosage regimens. Dosage regimens for patients with impaired kidney function. Pharmacokinetic drug interactions. Pharmacokinetic factors that require individualization of dosage regimens. Drug metabolism. Importance of stereoselectivity in therapeutics. Representative pharmacokinetic exercises for the understanding the effect of various parameters in the pharmacokinetic profiles of drug concentrations in plasma versus time, estimation of various pharmacokinetic parameters, and design of optimal dosage regimens. Ioannis Vizirianakis Protein binding of drugs, Intestine drug metabolism, Hepatic drug metabolism, Assessment of drug interactions mechanisms, Drug-drug drug-food and drug-herb interactions, Mechanisms involved in the emergence of adverse drug interactions, Pharmacogenomics and adjustment of drug dosage delivery, PK-based drug prescription principles, Pharmacoeconomy issues in drug delivery, Clinical relevance of drug metabolizing enzymes and transporters genetic polymorphism, Individualizing drug delivery dosage schemes in clinical practice, Environmental toxicants and drug delivery. Examples of pharmacokinetic case studies discussed: a)) cerivastatin market removal, b) removal of rofecoxib from the clinical practice ροφεκοξίμπης, c) drug-induced QT-elongation and drug cardiotoxicity and d) PK-based methodological improvements applied upon indinavir new drug development.
Educational Material Types
  • Notes
  • Slide presentations
  • Interactive excersises
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Communication with Students
Course Organization
ActivitiesWorkloadECTSIndividualTeamworkErasmus
Lectures39
Tutorial26
Total65
Student Assessment
Description
Two written interim examinations of each teacher (A) or a written examination in the overall course material at the end of the semester were applied (B). Students to pass the course based on two written interim exams should have achieved an average grade of at least 6. The examination time, both for the interim and the final exam, is 3 hours.
Student Assessment methods
  • Written Exam with Multiple Choice Questions (Formative, Summative)
  • Written Exam with Short Answer Questions (Formative, Summative)
  • Written Exam with Problem Solving (Formative, Summative)
Bibliography
Course Bibliography (Eudoxus)
1. Ιωάννης Νιώπας «Σημειώσεις Κλινικής Φαρμακοκινητικής», Τμήμα Εκδόσεων ΑΠΘ, Θεσσαλονίκη, 2010. 2. Ιωάννης Σ. Βιζιριανάκης «Κλινική Φαρμακοκινητική: Βασικές αρχές της φαρμακευτικής αγωγής στην κλινική πράξη», Έκδοση: 1/2010,.Εκδότης: Σταύρος Αντ. Σαρτίνας, Θεσσαλονίκη.
Additional bibliography for study
1. Ιωάννης Νιώπας. Στο e-Class του μαθήματος (στην ένδειξη «Έγγραφα») είναι αναρτημένες όλες οι διαφάνειες (slides) των διαλέξεων, καθώς και αντιπροσωπευτικές ασκήσεις Κλινικής Φαρμακοκινητικής. 2. Ιωάννης Σ. Βιζιριανάκης. Στο e-Class του μαθήματος (στην ένδειξη «Έγγραφα») είναι αναρτημένες όλες οι διαφάνειες (slides) των διαλέξεων (σύνολο 298), καθώς και το υλικό των φροντιστηριακών μαθημάτων που σχετίζονται με το εργαλείο “Simcyp-Population Based Pharmacokinetic Modelling and Simulation».
Last Update
09-09-2013