PHARMACEUTICAL CHEMISTRY (ORGANOMETALLICS AND HORMONES)

Course Information
TitleΦΑΡΜΑΚΕΥΤΙΚΗ ΧΗΜΕΙΑ (ΟΡΓΑΝΟΜΕΤΑΛΛΙΚΩΝ ΕΝΩΣΕΩΝ & ΟΡΜΟΝΩΝ) / PHARMACEUTICAL CHEMISTRY (ORGANOMETALLICS AND HORMONES)
Code34
FacultyHealth Sciences
SchoolPharmacy
Cycle / Level1st / Undergraduate
Teaching PeriodSpring
CommonNo
StatusActive
Course ID180000110

Programme of Study: Programme of Studies 2008-

Registered students: 229
OrientationAttendance TypeSemesterYearECTS
CoreCompulsory Course427

Class Information
Academic Year2018 – 2019
Class PeriodSpring
Faculty Instructors
Weekly Hours5
Class ID
600137728
Type of the Course
  • Scientific Area
Course Category
Specific Foundation / Core
Mode of Delivery
  • Face to face
Digital Course Content
Language of Instruction
  • Greek (Instruction, Examination)
Prerequisites
General Prerequisites
Basic knowledge of organic and inorganic chemistry are required.
Learning Outcomes
Upon successful completion of this course, the student will learn from the perspective of medicinal chemistry about how metals interact with the biological systems, how to apply chelation therapy against metal intoxication, how platinum anticancer and gold antirheumatic drugs are synthesized and work. Also they will learn about the properties (physical and biological) and general applications of MRI contrast agents and diagnostic radiopharmaceuticals.At the same time students will learn from the perspective of medicinal chemistry about the role of hormone from chemical , biological and therapeutical point of view. Also they will learn the strategy for the design, synthesis and structure-activity relationships of synthetic analogs of hormones.
General Competences
  • Apply knowledge in practice
  • Work autonomously
  • Work in teams
  • Work in an interdisciplinary team
  • Advance free, creative and causative thinking
Course Content (Syllabus)
Introduction to hormones. Classification of hormones and their studies from chemical, biological and therapeutical points of view. Design, synthesis, qualitative and quantitative evaluation of hormones, structure-activity relationships. Antagonist of hormones. Metabolism and mechanism of action. Role in the organism . Hormones as contraceptives. Insulin, calcitonin, hormones of hypophysis and hypothalamus.Role of hormones and metals in the biological systems. Introduction to coordination compounds. Metal compounds in the biological systems. Application of metal ligands in chelation therapy. Osteoporosis: design, synthesis and structure-activity relationships of biphosphonates.Platinum anticancer compounds, gold anti-rheumatic compounds(design, synthesis and structure-activity relationship). Metal compounds as diagnostics: Principles of design. MRI contrast agents, radiopharmaceuticals.
Educational Material Types
  • Notes
  • Slide presentations
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Communication with Students
Course Organization
ActivitiesWorkloadECTSIndividualTeamworkErasmus
Lectures39
Laboratory Work12
Total51
Student Assessment
Description
Student assessment is done by midterm exams (optional) or by written exam at the end of the semester for the course and by a written test of laboratory practice.
Student Assessment methods
  • Written Exam with Short Answer Questions (Summative)
Bibliography
Course Bibliography (Eudoxus)
Α. Γερονικάκη. «Οργανική Φαρμακευτική Χημεία . Ορμόνες». 3η έκδοση 2006. A. Geronikaki" Organic Pharmaceutical Chemistry. Hormones" 5th edition. 2013.
Additional bibliography for study
E. Chiotellis, D. Papagiannopoulou, «Chapters on Bioinogranic Pharmaceutical Chemistry» (in greek) Laboratory Experiment Notes, D. Papagiannopoulou (in greek) (users.auth.gr/papagd/Organometallika.)
Last Update
14-06-2013