ORGANIC PHARMACEUTICAL CHEMISTRY II

Course Information
TitleΟΡΓΑΝΙΚΗ ΦΑΡΜ/ΚΗ ΧΗΜΕΙΑ ΙΙ / ORGANIC PHARMACEUTICAL CHEMISTRY II
Code54
FacultyHealth Sciences
SchoolPharmacy
Cycle / Level1st / Undergraduate
Teaching PeriodSpring
CommonNo
StatusActive
Course ID180000112

Programme of Study: Programme of Studies 2008-

Registered students: 295
OrientationAttendance TypeSemesterYearECTS
CoreCompulsory Course635.5

Class Information
Academic Year2018 – 2019
Class PeriodSpring
Faculty Instructors
Weekly Hours5
Class ID
600137730
Type of the Course
  • Scientific Area
Course Category
Specific Foundation / Core
Mode of Delivery
  • Face to face
Erasmus
The course is also offered to exchange programme students.
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
Aims of the course:: -Relationships between chemical structure & physicochemical properties with the activity of drug molecules. -Molecular & chemical mode of action of drug molecules. -Chemical stability of drug molecules. -Biotransformatinos of xenobaiotics. -Representative synthetic strategies and chemical quantitative identification of drug molecules. Skills: -Practical implementation of the following types of reactions: a) oxidative modification, b) double nucleophilic attack on carbonyls, c) intramolecular rearrangement of a phenyl moiety, & d) thermodynamic formation of a heterocyclic ring under anhydrous conditions. -Gradual changes of the pH of the milieu aiming to the purification of organic drug molecules. -Identification/explanation of the fingerprint of drug molecules in the 1H-NMR spectrum. -Chemical oxido-reductive quantitative identification of drug molecule.
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Adapt to new situations
  • Make decisions
  • Work autonomously
  • Work in teams
  • Work in an international context
  • Work in an interdisciplinary team
  • Generate new research ideas
  • Design and manage projects
  • Appreciate diversity and multiculturality
  • Respect natural environment
  • Demonstrate social, professional and ethical commitment and sensitivity to gender issues
  • Be critical and self-critical
  • Advance free, creative and causative thinking
Course Content (Syllabus)
1) Vassilis Demopoulos Synthetic strategy, source identification-isolation, structural elucidation, analysis, molecular mechanism of action, selectivity, stability and bio-transformations for the following classes of drug molecules: antibacterial agents, antifungal agents, antiviral agents, diuretics, histamine receptor (H1 & H2) agonists and antagonists, non steroidal anti-inflammatory drugs (NSAIDs), drugs for the gout and rheumatoid arthritis (DMADs), introductive molecular modeling and statistical computational approaches. 2) Ioannis Nicolaou Pharmacochemical approach (as design, synthesis, physicochemical properties, target cell interactions, structure-activity relationships, pharmacochemical interpretation of toxicity, metabolism) of the below classes of drugs: antineoplastics & antineoplastic detoxifying agents, antidiabetic agents & agents for the treatment of obesity, renin inhibitors-angiotensin converting enzyme inhibitors & angiotensin II inhibitors, calcium channel blocking agents, nitrates (for the treatment of angina), platelet aggregation inhibitors, coumarins as anticoagulant, local anesthetics. 3) Dimitra Hadjipavlou-Litina Synthetic strategy-structural characterization-analysis-molecular mechanism of action, structure activity-relationships, selectivity, pharmacochemical aspect of activity and metabolism in the human organism of the following groups of drugs: acetyl-choline’s agonists and antagonists, inhibitors of acetyl-cholinesterase, anti-alzheimer, hybrid molecules, polotic and apopolotic agents, sympathomimetics (α- & β- receptor agonists), sympatholytics (α- & β- receptors antagonists), inhibitors of lipoxygenase.
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Communication with Students
Description
1) Vassilis Demopoulos, professor Lectures: The haptics (http://www.telegraph.co.uk/education/educationnews/8271656/Write-it-dont-type-it-if-you-want-knowledge-to-stick.html) approach is used 2) Ioannis Nicolaou Lectures, notes, statements etc are presented in the corresponding place of the website of the School of Pharmacy. 3) Dimitra Hadjipavlou-Litina, professor Lectures, notes, statements etc are presented in the corresponding place of the website of the School of Pharmacy.
Course Organization
ActivitiesWorkloadECTSIndividualTeamworkErasmus
Lectures99
Laboratory Work66
Total165
Student Assessment
Description
The evaluation of knowledge and skills which have been acquitted by the students from the course work is attested with written examinations (80% of the final grade + 20% of experimental aptitude) which are conducted in a fixed date. The written examinations have duration of 3.5h, and consist of approximately ten (10) composite questions spherically covering the tough subjects. Grading is proportionally allocated to the tutors. Optional periodic examinations, partially covering the tough subject, could be also arranged between tutors and students.
Student Assessment methods
  • Written Exam with Short Answer Questions (Summative)
  • Written Assignment (Formative)
Bibliography
Course Bibliography (Eudoxus)
Βασίλης Ι. Δημόπουλος "ΦΑΡΜΑΚΕΥΤΙΚΗ ΧΗΜΕΙΑ- Ομάδες Χημειοθεραπευτικών και Φαρμακοδυναμικών Φαρμάκων", Θεσσαλονίκη 2002, ISBN 960-317-063-1
Additional bibliography for study
1) Βασίλης Δημόπουλος • Richard B. Silverman “The Organic Chemistry of Drug Design and Drug Action”, Academic Press, 2004, ISBN-10: 0126437327 • Annual Reports in Medicinal Chemistry, http://www.sciencedirect.com/science/bookseries/00657743 • Joseph J. Cannon “Pharmacology for Chemists”, Oxford University Press, 2007, ISBN-10: 0841239274 • E. J. Corey, B. Czako, L. Kurti “Molecules and Medicine”, Wiley, 2007, ISBN-10: 0470227494 2) Ιωάννης Νικολάου • Journal of Medicinal Chemistry (ACS Publications) • Bioorganic & Medicinal Chemistry Letters - Elsevier • Bioorganic & Medicinal Chemistry (ISSN 0968-0896) • The Journal of Biological Chemistry • Chemical Research in Toxicology (ACS Publications) • Drug Metabolism and Disposition 3) Δήμητρα Χατζηπαύλου-Λίτινα • Medicinal Chemistry Principles and Practice, Ed. F.D.King. 1994, The Royal Society of Chemistry, ISBN 0-85186-494-5 • Contemporary Drug Synthesis Li J.J, Johnson D., Sliskovic D., Roth B. Wiley-Interscience,2004, ISBN 0-471-21480-9 • New Trends in Synthetic Medicinal Chemistry, Ed. F. Gualtieri, Wiley –VCH, Vol. 7, 2000 • Annual Reports in Medicinal Chemistry, Academic Press • Journal of Medicinal Chemistry (ACS Publications) • Bioorganic & Medicinal Chemistry Letters - Elsevier • Bioorganic & Medicinal Chemistry (ISSN 0968-0896) • “Practical Pharmaceutical Chemistry part I, II) The Athlone Press 1975 • “Principles of Medicinal Chemistry” W.O. Foye, ed. Lea & Febiger, 1995 • “Remington’s Pharmaceutical Sciences”, Osol A. ed. Mack Publishing Co., 1980 • « Goodman & Gilman’s The Pharmacological Basis of Therapeutics » Goodman a., Hardman J., Limbird L., eds MacMillan Publishing Co 2001 • “Strategies for Organic Drug Synthesis and Design” Lednicer, D., ed. Wiley J. & Sons 2000 • ”Essentials of Pharmacology” Theocharidis T. Little, Brown & Company 2nd edition, 1999 • Drug Actions, Basic Principles and Therapeutic Aspects, Mutschler/Devendorf • Archiv.Pharm 317, 183-185, 1984 • Arch Pharm 325, 483-90, 1992. • Arch Pharm 328, 689-698, 1995 • Intensive Care Med. 18, 449-454, 1992 • Greenblatt et al. (1999) FEBS Letters 463, p321 • Dvir et al. (2003) JACS 125, p363 • Bar-On et al. (2002) Biochemistry 41, p3555. • Kryeger et al.,(1997) Structure 7,297 • Raves et al. (1997) Nature Structural Biology 4, p57 • Εθνικό Συνταγολόγιο 2007, Εθνικός Οργανισμός Φαρμάκων
Last Update
22-11-2016