PHARMACOGNOSY 2

Course Information
TitleΦΑΡΜΑΚΟΓΝΩΣΙΑ 2 / PHARMACOGNOSY 2
CodeΝΠ34
FacultyHealth Sciences
SchoolPharmacy
Cycle / Level1st / Undergraduate
Teaching PeriodSpring
CommonNo
StatusActive
Course ID180000275

Programme of Study: Programme of Studies 2008-

Registered students: 224
OrientationAttendance TypeSemesterYearECTS
CoreCompulsory Course635.5

Class Information
Academic Year2018 – 2019
Class PeriodSpring
Faculty Instructors
Instructors from Other Categories
Weekly Hours5
Class ID
600137840
Type of the Course
  • Scientific Area
Course Category
Specific Foundation / Core
Mode of Delivery
  • Face to face
Digital Course Content
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
Understanding by the students of the substances belonging to groups of terpenoids and steroids and their derivatives. In order to achieve these objectives, the physical, chemical and biological properties of these substances are presented, as well as their chemical classification, their biosynthesis and medicinal plants containing them. It will also discussed uses of medicinal plants whose main active ingredients belong in these categories of natural products. Moreover, in the laboratory work the students will know and will analyze herbal medicines included in the European Pharmacopoeia 5, using the appropriate analytical methods (microscopic and phytochemical). Skills: Familiarity and in depth knowledge of phytochemical groups of terpenoids and steroids and their derivatives, as well as of herbal medicines containing them.
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Generate new research ideas
  • Design and manage projects
  • Respect natural environment
Course Content (Syllabus)
TERPENOIDS AND STEROIDS AND THEIR DERIVATIVES Introduction. Origin of C5 units. Mevalonic acid pathway and GAP/pyruvate pathway for IPP formation. • Monoterpens: Introduction, chemical structures of monoterpenes. Biosynthesis. • Sesquiterpenes: General structures of sesquiterpenes • Essential oils: Definition, distribution in plants and their functionality. Physical properties. Chemical constitution. Terpenoids and sesquiterpenoids of essential oils. Factors that influenced the diversity of essential oils (chemotypes, influence of the vegetation cycle, environmental factors, etc.). Techniques and methods used to produce essential oils. Quality control of essential oils. Pharmacological properties. Toxicity. Uses. Storage and preservation of essential oils and aromatic plants. Lesions. • Aromatic and medicinal plants.  Apiaceae: Pimpinella anisum L., Foeniculum spp., Anethum graveolens, Carum carvi L., Coriandrum sativum L., Apium graveolens L., Petroselinum crispum (Mill.) A.W.Hill  Asteraceae: Chamomilla recutica (L.), Artemissia vulgaris L., A. absinthum L. and A. dracunculus L.  Lamiaceae: Ocinum basilicum L., Lavandula spp., Origanum majorana L., Melissa officinalis L., Mentha x piperita L., Origanum vulgare L., Rosmarinus officinalis, Satureja montana L., Salvia spp., Thymus vulgaris L. and T. serpyllum L.  Lauraceae: Cinnamomum verum J.Presl (Κεϋλάνης), C. aromaticum Nees (China), C. camphora L., Laurus nobilis L.  Myrtaceae: Syzygium aromaticum, Eucalyptus globulus  Rutaceae: Citrus aurantium L., Aurantium spp., etc. essential oils of Citrus spp. • Oleoresins and related products from Pinus spp.: Turpentine, Juniperus spp. • Iridoids and Seco-iridoids: General structures, Biosynthesis, Extraction Isolation and Identification, Biological and Pharmacological properties. Medicinal plants containing iridoids: Valeriana officinalis, Harpagophytum procumbens, Olea europaea L., Gentiana lutea, Centaurium erythreae, Menyanthes trifoliate, Lamium album L. • Pyrethrines: Structures, Biological properties. Medical uses. Chrysanthemum cinerariafolium. • Cannabinoids: Chemical structures, biosynthesis, quality control of cannabinoids. Cannabis herb. • Sesquiterpenoids. Cnicus benedictus (cnicin), Αrtemisia absinthun L. (artabsin, chamazulene), Matricaria recutica, Chamaemelum nobilis (German Chamomile), Picrotoxin, Picrotin, Artemissia annua, Cantharidine. • Sesquiterpene lactones: chemical structures, biological properties, medical uses. Artemisia annua L. (artemisinin), Arnica montana L., Inula helenicum. Tanacetum parthenium, Sesquiterpene lactones and allergy. • Diterpenes: chemical structures, biosynthesis, medical uses. Taxus spp., Teucrium spp., Stevia rebaudiana. Poisonous plants containing diterpenes (phorbol and ingenol esters): Daphne spp. and Euphorbia spp. Toxicity. Rhpdodendron spp., Ericaceae spp. (Kalmia, Pieris). • Triterpenes and steroids. General chemical structures. Biosynthesis. • Steroid and triterpenoid saponins. Extraction, chromatographic separation, quantitative determination, biological and pharmacological properties. Semi-synthetic production of steroidal hormones. Dioscorea spp., Agave siaalana, Solanum spp. Sterols. • Glycyrrhiza glabra., Aesculus hippocastanum, Ruscus aculeatus, Polygala senega, Hedera helix, Primula veris, Centella asiatica, Calendula officinalis. • Adaptogenic plants: Panax ginseng, Eleutherococcus senticosus • Plants containing saponosides: Quillaia saponaria, Saponaria officinalis, Gypsophila spp. • Cordial glycosides. Chemical structures, biosynthesis, physicochemical properties, quality and quantity control, pharmacological properties, therapeutic indications. • Plants containing cordial glycosides: Digitalis spp., D. purpurea and D. lanata (digoxin, digitoxin, deacetyl-lanatosid C), Urginea matitima, Strophanthus spp, Convallaria majalis, Adonis vernalis, Heleborus niger, Nerium oleander. • Poison Toad, Bufotoxin. • Vitamin D. Biosynthesis, production, properties. Cod Liver Oil. • Vitex agnus-castus L., Urtica dioica L. • Cucurbitacins, boswellic acids, limonoids, quassinoids. • Tetraterpenes (C40), carotenoids. Biosynthesis, properties, uses. • Chemistry of Vitamin A. • Plants containing carotenoids: Capsicum spp., Crocus sativus L. LABORATORY WORK: Microscopic and Phytochemical control of herbal drugs containing terpenes and/or terpene derivatives of the European Pharmacopoeia 5. Microscopic control: Folia Menthae, Folia Melissae, Folia Lavandulae, Folia Salviae, Folia Digitalis, Radix Liquiritiae, Herba Absinthii, Flores Chamomillae, Radix Valerianae, Herba Cannabis, Radix Gentianae, Folia Eucalypti Phytochemical control: Digitalis purpurea: chromatographic control – qualitative and quantitative determination of cordial glycosides. Radix Liquiritiae: chromatographic quality control.
Educational Material Types
  • Notes
  • Slide presentations
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
Course Organization
ActivitiesWorkloadECTSIndividualTeamworkErasmus
Lectures39
Laboratory Work26
Total65
Student Assessment
Description
Written exam at the end of the semester. To compute the final grade, the grade which is given by each tutor (5.0) is added. The examination at the end of the semester is performed at dates, time and place arranged by the department The duration of the examination is 3 hours for the two tutors.
Student Assessment methods
  • Written Exam with Short Answer Questions (Summative)
Bibliography
Course Bibliography (Eudoxus)
Gunnar Samuelson, ΦΑΡΜΑΚΕΥΤΙΚΑ ΠΡΟΪΟΝΤΑ ΦΥΣΙΚΗΣ ΠΡΟΕΛΕΥΣΗΣ, Απόδοση στην Ελληνική: Π. Κορδοπάτης, Ε. Μάνεση-Ζούπα, Γ. Πάιρας, Πανεπιστημιακές Εκδόσεις Κρήτης, Ηράκλειο 1996
Additional bibliography for study
1. European Pharmacopoeia 5. 2. J. Bruneton. Pharmacognosie, Phytochimie, Plantes médicinales 3th édition Ed. TEC/DOC Paris 1999. 3. R. Hansel, O. Sticher. Pharmacognosie-Phytopharmazie. 7 Auflage, Springer-Verlag, Berlin-Heidelberg 2004. 5. Σημείωσεις που διανέμονται από τους διδάσκοντες
Last Update
12-08-2013