Physical Pharmacy

Course Information
TitleΦυσική Φαρμακευτική / Physical Pharmacy
FacultyHealth Sciences
Cycle / Level1st / Undergraduate
Teaching PeriodWinter
Course ID600013756

Programme of Study: PPS Tmīmatos Farmakeutikīs (2018-)

Registered students: 0
OrientationAttendance TypeSemesterYearECTS
KORMOSCompulsory Course534

Class Information
Academic Year2019 – 2020
Class PeriodWinter
Weekly Hours3
Class ID
Mode of Delivery
  • Face to face
Digital Course Content
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
The course's objective is to promote the understanding of the physicochemical principles of pharmaceutics, and the interrelations between the physical properties of the raw materials and those of the pharmaceutical formulations and final dosage forms.
General Competences
  • Apply knowledge in practice
  • Work in an interdisciplinary team
Course Content (Syllabus)
Gases-vapors-supercritical fluids: Physical properties, applications. Solids: Crystalline state: structure, polymorphism, optical properties, imperfections. Phase transitions. Solvates - Hydrates, co-crystals, salts. Amorphous state: preparation, properties (glass transition), advantages. Solid dispersions: Types and methods of manufacture. Solubility and solution properties: solubility, thermodynamic properties of solvents, solvents. Ionization of drugs in solutions (weak acids, bases, ampholytic drugs, buffers). Osmotic solution properties. Partition between immiscible solvents. Diffusion (Fick's laws, membrane permeability and experimental diffusion study). Solution rate: Noyes-Whitney Act, endogenous dissolution rate. Stability of drugs: chemical disruption of drugs, mechanisms and kinetics of disintegration in solutions, mechanisms and kinetics of solid degradation. Rheology: Viscosity, Newtonian and non-Newtonian fluids (plastic, pseudoplastic and expanding flow), thixotropy, experimental determination of viscosity. Surface - interfacial phenomena: surface tension - spreading - solidification of solids - experimental determination of the surface tension factor. Tachyactive substances - micelles - solubilization - liquid crystals. Bulky dispersion systems: DLVO theory of stability of dispersion systems. Suspensions, emulsions, microemulsions (preparation, stability). Polymer science elements: classification, molecular characterization, synthesis, crystallinity, dissolution (Flory-Huggins theory), swelling, polymer applications in pharmacy. The course includes laboratory practical exercises. The processing of the experimental data, as well as their presentation, requires the use of a computer.
Educational Material Types
  • Notes
  • Slide presentations
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Communication with Students
Course lectures in the form of powerpoint presentation, available to the students through the Blackboard academic platform.
Course Organization
Laboratory Work25
Student Assessment
Final examination at the end of the semester - submission of a practical lab report. Questionaire available to the students through the Blackboard academic platform.
Student Assessment methods
  • Written Exam with Short Answer Questions (Formative, Summative)
  • Written Assignment (Formative, Summative)
Additional bibliography for study
Εργαστηριακές Σημειώσεις Φυσικής Φαρμακευτικής
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