After completing the course, the students will be able to understand the basic concepts of 1) pharmacokinetics - to the extent that they are able to perform simple pharmacokinetic calculations (e.g., loading dose, maintenance dose) and can estimate the probability of drug-drug interactions, 2) pharmacodynamics, so that they understand the concept of agonism and antagonism, as well as the relation between mechanism of action, efficacy, toxicity, clinical utility, indications, contra-indications, adverse reactions, and pharmacodynamic drug-drug interactions, and 3) the basic properties (pharmacokinetics, mechanism of action, indications, adverse effects, contraindications) of drugs acting on the parasympathetic, sympathetic and central nervous system, so that they can understand better their clinical utility in future courses and administer them safely in clinical praxis.
Course Content (Syllabus)
Introduction in Pharmacology; terminology. Principles of pharmacokinetics (absorption, distribution, metabolism, excretion). Pharmacodynamics (receptors; agonists/antagonists; adverse effects). Clinical relevance of pharmacokinetics and pharmacodyanmics - Special groups of patients. Pharmacology of the autonomic nervous system (cholinergic agonists/antagonists; adrenergic agonists/antagonists). Pharmacology of the central nervous system (antiparkinsonic drugs, anxiolytics, hypnotics, antiepileptic drugs, stimulants, anesthetics, antidepressive drugs, neuroleptic drugs, opioids). Drug abuse. Methodology and measurement in pharmacology (proclinical/ clinical development of drugs).
pharmakological definitions, pharmakokinetics, pharmakodynamics, agonist, antagonist, adrenergic, cholinergic, CNS, cardiovascular
Course Bibliography (Eudoxus)
1. ΦΑΡΜΑΚΟΛΟΓΙΑ, Humphrey G. Rang, James M. Ritter, Rod Flower, Graeme Henderson, Έκδοση: 8η/2018, ΕΚΔΟΣΕΙΣ ΠΑΡΙΣΙΑΝΟΥ, ΑΘΗΝΑ
2. GOODMAN & GILLMANS Η ΦΑΡΜΑΚΟΛΟΓΙΚΗ ΒΑΣΗ ΤΗΣ ΘΕΡΑΠΕΥΤΙΚΗΣ, Έκδοση: 2η έκδ./2015, Συγγραφείς: Brunton L. ΕΚΔΟΣΕΙΣ BROKEN HILL PUBLISHERS LTD, ΑΘΗΝΑ 2015
3. ΦΑΡΜΑΚΟΛΟΓΙΑ, Έκδοση: 6η/2015, Συγγραφείς: HARVEY A. RICHARD,KAREN WHALEN,RICH.FINKEL,TH.A.PANAVELIL, ΕΚΔΟΣΕΙΣ ΠΑΡΙΣΙΑΝΟΥ, ΑΘΗΝΑ 2015