Hematologic Manifastations in Systematic Diseases

Course Information
TitleΑΙΜΑΤΟΛΟΓΙΚΕΣ ΕΚΔΗΛΩΣΕΙΣ ΣΤΑ ΣΥΣΤΗΜΑΤΙΚΑ ΝΟΣΗΜΑΤΑ / Hematologic Manifastations in Systematic Diseases
FacultyHealth Sciences
Cycle / Level1st / Undergraduate
Teaching PeriodSpring
CoordinatorVasileios Perifanis
Course ID200000435

Class Information
Academic Year2021 – 2022
Class PeriodWinter
Faculty Instructors
Weekly Hours2
Class ID
6. .
Course Type 2016-2020
  • Scientific Area
Course Type 2011-2015
Specific Foundation / Core
Mode of Delivery
  • Face to face
Digital Course Content
The course is also offered to exchange programme students.
Language of Instruction
  • Greek (Instruction, Examination)
  • English (Instruction, Examination)
Learning Outcomes
PURPOSE The purpose of this course is to display the most representative aquired Ηematological Μanifestations associated with Systemic Diseases, which can be life-threatening, as their early recognition and, thus, successful treatment can be life-saving. Particular emphasis is placed on Immuno-hematology, since nowadays, in many blood diseases, even neoplasms, therapies are successfully applied based on the principles of immunology-immunotherapy. Learning objectives Τhe courses and their applications aim that at the end the students will be able to: - Understand the dynamics between the different blood diseases in order to properly approach the diagnosis of specific conditions, such as in pregnancy, surgery, etc., and properly deal with any complications - Become aware of the hematological manifestations related to underdiagnosed diseases, resulting in early diagnosis, such as: haemolytic anemia and/or thrombosis in paroxysmal nocturnal hemoglobinuria or thrombocytopenia as the first manifestation in a patient with AIDS, who will be promptly referred for further examination - Become aware of the state-of-the art laboratory research skills and how they are applied - Know how to deal with these conditions, their prophylaxis and treatment and how to be proactive with the purpose of avoiding potential life-threatening complications, such as pulmonary embolism or severe bleeding - Safely apply the knowledge acquired in more specific situations, and adapt it, in the future, to matters relating to his/her specialization - Conduct work related to the subject taught
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Adapt to new situations
  • Make decisions
  • Work autonomously
  • Work in an interdisciplinary team
  • Be critical and self-critical
  • Advance free, creative and causative thinking
Course Content (Syllabus)
Hematologic manifestations in autoimmune and rheumatic diseases (bone marrow and peripheral blood disorders in rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, hematophagocytosis syndrome, chronic disease anemia) Hematologic manifestations that accompany cardiovascular diseases, which comprise the most common diseases in the Western World Hematologic manifestations in liver diseases (anemia, disorders in hemostasis, hemorrhagic events, the effect of alcohol abuse, specific disorders associated with orthotopic liver transplantation) Hematologic manifestations in kidney diseases (Chronic Renal Disease anemia, hemorrhagic disorders in uremia, thrombotic microangiopathies-Thrombotic Thrombocytopenic Purpura) Hematologic manifestations in cancer (anemia, leukocyte, erythrocyte and platelet disorders, bleeding and thrombosis). Immunology of cancer, cancer antigens, basic principles of cancer immunotherapy, Hematopoietic Cell Transplantation, immunotherapy of malignant blood diseases, contemporary cell therapies with CAR-T cells. Hematological implications in the surgical patient (perioperative bleeding and thrombosis, causes and treatment in specific patient groups) Hematological implications in pregnancy (preeclampsia and HELLP syndrome, Diffuse Intravascular Coagulation, obstetric complications and thrombophilia, thrombosis and contraceptives) Diseases originating from the activation of the Complement System (Paroxysmal Nocturnal Hemoglobinuria and atypical Hemolytic Uremic Syndrome - various clinical manifestations, state-of-the art laboratory diagnostic tools and therapy) Hematological manifestations in HIV infection (anemia, neutropenia, thrombocytopenia as the first manifestation of the disease, HIV related lymphomas, etc.). Hematological manifestations in pediatric diseases (juvenile rheumatoid arthritis, Kawasaki syndrome, Henoch-Schonlein syndrome, cystic fibrosis, celiac disease, thromboembolic disease in children)
Hematological manifestations, Systematic Diseases
Educational Material Types
  • Notes
  • Slide presentations
  • Multimedia
  • Interactive excersises
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
Course Organization
Laboratory Work60.2
Reading Assigment40.2
Clinical Practice40.2
Written assigments60.2
Student Assessment
20% class participation, 80% preparation of final paper Suggested paper topics: • Haematological manifestations in rheumatic diseases • The Complement System-Developments in therapy with monoclonal antibodies • Immunotherapy in Cancer. Basic principles and applications • Thromboembolic disease in children • Thrombosis and contraceptives • Thrombotic microangiopathies associated with pregnancy • Thrombotic Thrombocytopenic Purpura – Up-to-date diagnosis and treatment • Paroxysmal nocturnal hemoglobinuria – Pathophysiology, clinical manifestations and state-of-the art treatment • Haemostasis disorders in orthotopic liver transplantation • Hematological manifestations in hemodialysis patients • Haemophilia and Acquired Inhibitors - Diagnostic approach and contemporary treatment • Antiphospholipid Syndrome - Clinical manifestations- Diagnosis- Treatment • Immunology of Transplantation • The Kidney and the Blood • Innovative cellular treatments with CAR T Cells • CAR T cells and autoimmune diseases • CAR T cells in Regenerative Medicine • CAR T cells in the treatment of infections • CAR T cells in the treatment of solid tumor neoplasms
Student Assessment methods
  • Written Assignment (Formative, Summative)
  • Oral Exams (Summative)
Course Bibliography (Eudoxus)
Βιβλίο του Τομέα Παθολογίας, πρόσφατη έκδοση Internal Medicine Educational Book, latest edition
Additional bibliography for study
ASH Education book, www.hematology.org Hematology Hoffman, www.expertconsult.com, www.mayoclinic.org, www.medscape.com
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