Bioreactor Design and Operation

Course Information
TitleΣχεδιασμός και Λειτουργία Βιοαντιδραστήρων / Bioreactor Design and Operation
SchoolChemical Engineering
Cycle / Level2nd / Postgraduate
Teaching PeriodSpring
Course ID600018393

Programme of Study: GSP CHEMICAL AND BIOMOLECULAR ENGINEERING (2020- until now)

Registered students: 6
OrientationAttendance TypeSemesterYearECTS
HEALTH-FOODCompulsory Course belonging to the selected specialization (Compulsory Specialization Course)217

Class Information
Academic Year2021 – 2022
Class PeriodSpring
Faculty Instructors
Weekly Hours3
Class ID
Course Type 2016-2020
  • Scientific Area
Course Type 2011-2015
Specific Foundation / Core
Mode of Delivery
  • Face to face
  • Distance learning
Language of Instruction
  • Greek (Instruction, Examination)
  • English (Instruction, Examination)
Learning Outcomes
At the end of the course the students will be able to: • Elaborate on the optimal design of a bioreactor using advanced optimization-based techniques. • Justify clearly the results of a technical or research project based on underlying assumptions and present them both in a technical and non-technical audience. • Acquire the learning skills which will allow them to continue or/and implement their studies in an independent way.
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Make decisions
  • Work autonomously
  • Work in teams
  • Design and manage projects
  • Respect natural environment
  • Advance free, creative and causative thinking
Course Content (Syllabus)
The purpose of the course is to give an up-to-date overview of a variety of emerging techniques and methods used for the design and efficient operation of bioreactors, given their essential role as artificial harbours for growing and maintaining cell cultures. That task decomposes into several endeavours necessary to accomplish and generally requires a wide set of engineering theory including among others basic engineering principles, systems biology and conceptual design theory. COURSE STRUCTURE 1. Challenges for Bioreactor Design and Operation 2. Bioreactor Designs and Cell Kinetics 3. Gas-Liquid Mass Transfer 4. Experimental Measurement Techniques 5. Sterility in Industrial Bioreactors 6. Scale-Up Methodologies for Bioreactors 7. Bioreactor Applications - A case-study 8. Integration of Bioreactors with Downstream Steps Project
Microbial Systems, Culture growth, Cells harvesting, Batch-Fedbatch bioreactor operations, Feeding strategies
Educational Material Types
  • Slide presentations
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
Course Organization
Reading Assigment301
Student Assessment
Student Assessment methods
  • Written Exam with Multiple Choice Questions (Formative)
  • Written Exam with Short Answer Questions (Formative)
  • Written Exam with Extended Answer Questions (Formative)
  • Written Assignment (Formative)
  • Written Exam with Problem Solving (Formative)
Course Bibliography (Eudoxus)
1."Bioreactors-Design, Operation and Novel Applications" Carl-Fredrik Mandenius, Wiley-VCH Verlag GmbH & Co (2016) 2."Multiphase Bioreactor Design", J. M.S.Cabral, M.Mota, J.Tramper, Taylor & Francis, N.Y. (2001) 3."An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer",E. Kadic, T.J. Heindel,Wiley, N.Y. (2014)
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