Course Information
FacultyHealth Sciences
Cycle / Level1st / Undergraduate
Teaching PeriodWinter
Course ID180000047

Class Information
Academic Year2018 – 2019
Class PeriodWinter
Faculty Instructors
Weekly Hours5
Class ID
Course Type 2016-2020
  • Scientific Area
Course Type 2011-2015
Specific Foundation / Core
Mode of Delivery
  • Face to face
Digital Course Content
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
• To acquire knowledge on basic concepts and tests of Toxicology, mechanisms of action of various toxic substances and their toxic effects on various organs and tissues of the body. • To acquire knowledge of clinical toxicology (symptoms, therapeutic measures, antidotes, detoxification measures) of various toxic substances or drugs, and to acquire knowledge about substances used for doping of athletes (doping) Study of the toxicity of various environmental factors [based either on the biological responses (eg, carcinogenicity and teratogenicity) or on the effects on specific target organs] as well as protection capacities. Correlation of the physiological processes and the molecular mechanisms responsible for the corresponding toxicity Students are tought how to search for the relevant information so that they can later seek bibliography and deepen and other issues not covered during the one semester
General Competences
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Work in teams
  • Advance free, creative and causative thinking
Course Content (Syllabus)
Introduction to Toxicology. Basic principles of the action of toxic substances. Toxicity testing in animals. Toxicokinetics: Absorption, distribution and excretion of toxic substances. Metabolism of toxic substances (xenobiotics). Mechanisms of nephrotoxicity and renal failure. Mechanisms of hepatotoxicity. Mechanisms of toxicity to the skin. Poisons and poisoning. Therapeutic management of poisoning - general and specific antidotes. Drug abuse of drugs and substances in sport (doping): Anabolics/Androgens, CNS stimulants, beta-blockers, diuretics, narcotics/analgesics, human growth hormone, erythropoietin and blood, ergogenic vitamins, non-pharmaceutical doping, control of doping. Clinical Toxicology I: Toxicokinetics, treatment of acute poisoning, supportive measures, measures to reduce absorption of toxic substances, measures to increase excretion of toxic substances. Clinical Toxicology II: Paracetamol, salicylates, cardiac glycosides, ethanol, tricyclic antidepressants, benzodiazepines, derivatives phenothiazins, anticholinergics, amphetamine and related compounds, opioids, pesticides (chlorinated hydrocarbons, organophosphorus esters, carbamates), cyanide, iron, mercury. Mutagenesis – toxicogenomics – new technologies in toxicology. Carcinogenesis from environmental factors (chemicals, viruses, drugs, radiation) Teratogenesis Nervous system toxicity. Toxicity of hematopoietic system. Respiratory system toxicity. Cardiovascular system toxicity
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Laboratory Teaching
  • Use of ICT in Communication with Students
Course Organization
Reading Assigment802.7
Student Assessment
Student Assessment methods
  • Written Exam with Short Answer Questions (Summative)
  • Written Assignment (Summative)
  • Oral Exams (Summative)
  • Performance / Staging (Summative)
Course Bibliography (Eudoxus)
1. ΤΣΙΦΤΣΟΓΛΟΥ ΑΣΤΕΡΙΟΣ «ΒΑΣΙΚΗ ΚΑΙ ΚΛΙΝΙΚΗ ΤΟΞΙΚΟΛΟΓΙΑ», Έκδοση: 1/1997, Εκδότης: ΧΑΡΙΣ ΕΠΕ 2. Ιωάννης Νιώπας «Σημειώσεις Αναλυτικής - Κλινικής Τοξικολογίας», (είναι αναρτημένες στο eClass του μαθήματος) Α. ΚΟΥΤΣΕΛΙΝΗΣ «Τοξικολογία (επίτομο)», Έκδοση: 1η έκδ./2004, Εκδότης: ΠΑΡΙΣΙΑΝΟΥ ΑΝΩΝΥΜΗ ΕΚΔΟΤΙΚΗ ΕΙΣΑΓΩΓΙΚΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΙΑ ΕΠΙΣΤΗΜΟΝΙΚΩΝ ΒΙΒΛΙΩΝ Νέου Π. «Κλινική Τοξικολογία & Θεραπευτική Αντιμετώπιση Δηλητηριάσεων», Έκδοση: 1η εκδ., Εκδότης: ΕΚΔΟΣΕΙΣ Π.Χ. ΠΑΣΧΑΛΙΔΗΣ
Additional bibliography for study
Επικαιροποίηση μέσω των διαλέξεων, ένα τμήμα των οποίων, ως αρχεία .pdfs, εμφανίζονται στην ιστοσελίδα:
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