Learning Outcomes
Upon successfully completing this course, students will be familiar with:
• Simple and multiple linear models applied to medical data (linear, logistic, Poisson, Cox)
• Assumptions and conditions that should be met for the application of these models
• The goodness of fit test to evaluate the performance of the models
• The necessary conditions that must exist in order to qualify as one or more variables as confounding in a relationship of outcome and exposure
• The concept of effect modification, and how it differs from confounding
• The usefulness of multiple regression techniques to analyze the relationship of an exposure to a predictive variable in the possible presence of confounding factors by using adjusted analysis
• Sample size calculation for multivariable models
Course Content (Syllabus)
1. Data investigation and editing, guidance for constructing graphs using R program (practice R)
2. Linear relationship between two quantitative variables (Scatter plots, Pearson’s & Spearman’s correlation) (practice R)
3. Theory of Linear Regression Models and their importance in medical research and practice
4. Confounding and effect modification
5. Simple and multiple linear regression analysis and applications in medical data (in practice R)
6. Simple and multiple logistic regression analysis and applications in medical data (in practice R)
7. Simple and multiple Poisson regression analysis and applications in medical data (in practice R)
8. Simple and multiple Cox regression and applications in medical data (in practice R)
Additional bibliography for study
1. Aho, Ken A. Foundational and applied statistics for biologists using R. CRC Press, 2013.
2. Bland, Martin. An introduction to medical statistics. 3rd Edition. Oxford University Press, 2000.
3. Crawley, Michael J. Statistics: an introduction using R, 2nd Edition. John Wiley & Sons, 2014.
4. MacFarland, Thomas W. Introduction to Data Analysis and Graphical Presentation in Biostatistics with R. Springer, 2014.
5. Daniel, Wayne W., and Chad L. Cross. Biostatistics: A Foundation for Analysis in the Health Sciences: A Foundation for Analysis in the Health Sciences. Wiley Global Education, 2012.
6. Logan M. Biostatistical Design and Analysis Using R: A Practical Guide. Wiley-Blackwell, 2010.
7. Aviva Petrie, Caroline Sabin. Medical Statistics at a Glance, 3rd Wiley 2009.
8. David G. Kleinbaum, Mitchel Klein. Survival Analysis: A self-learning text. 3rd Edition. Springer 2012.
9. David G. Kleinbaum. Logistic Regression: A self-learning text. 3rd Edition. Springer 2010.
10. Faraway, J. J. (2014). Linear Models with R (Chapman & Hall/CRC Texts in Statistical Science) (2nd ed.). Chapman and Hall/CRC.