Clinical Periodontology III

Ν/Α

As above

Performance during the seminars and at the final exam

Basic principles of periodontal regeneration - Prognosis of regenerative outcomes depending on defect characteristics - Guided tissue regeneration (GTR): Basic principles 1. Pagni G, Tavelli L, Rasperini G. The Evolution of Surgical Techniques and Biomaterials for Periodontal Regeneration. Dent Clin North Am. 2022 Jan;66(1):75-85. doi: 10.1016/j.cden.2021.06.003. Epub 2021 Aug 12. PMID: 34794555. 2. Bartold M, Ivanovski S. Stem Cell Applications in Periodontal Regeneration. Dent Clin North Am. 2022 Jan;66(1):53-74. doi: 10.1016/j.cden.2021.06.002. Epub 2021 Aug 13. PMID: 34794554. 3. Hasturk H. Inflammation and Periodontal Regeneration. Dent Clin North Am. 2022 Jan;66(1):39-51. doi: 10.1016/j.cden.2021.08.003. Epub 2021 Oct 9. PMID: 34794553. 4. Hasturk H. Inflammation and Periodontal Regeneration. Dent Clin North Am. 2022 Jan;66(1):39-51. doi: 10.1016/j.cden.2021.08.003. Epub 2021 Oct 9. PMID: 34794553. 5. Lindhe’s textbook chapter 45, 6th edition 6. Bartold PM. Group C. Initiator paper. Periodontal regeneration--fact or fiction? J Int Acad Periodontol. 2015 Jan;17(1 Suppl):37-49. PMID: 25764590. 7. Cochran DL, Cobb CM, Bashutski JD, Chun YH, Lin Z, Mandelaris GA, McAllister BS, Murakami S, Rios HF. Emerging regenerative approaches for periodontal reconstruction: a consensus report from the AAP Regeneration Workshop. J Periodontol. 2015 Feb;86(2 Suppl):S153-6. doi: 10.1902/jop.2015.140381. Epub 2014 Oct 15. PMID: 25317603; PMCID: PMC4469971. 8. Kao RT, Nares S, Reynolds MA. Periodontal regeneration - intrabony defects: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015 Feb;86(2 Suppl):S77-104. doi: 10.1902/jop.2015.130685. Epub 2014 Sep 12. PMID: 25216204. Membranes for GTR procedures 1. Caffesse RG, Nasjleti CE, Plotzke AE, Anderson GB, Morrison EC. Guided Tissue Regeneration and Bone Grafts in the Treatment of Furcation Defects. J Periodontol. 1993 Nov;64 Suppl 11S:1145-1153. doi: 10.1902/jop.1993.64.11s.1145. PMID: 29539698. 2. Needleman IG, Giedrys-Leeper E, Tucker RJ, Worthington HV. Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev. 2001;(2):CD001724. doi: 10.1002/14651858.CD001724. Update in: Cochrane Database Syst Rev. 2006;(2):CD001724. PMID: 11406001. 3. Murphy KG, Gunsolley JC. Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Ann Periodontol. 2003 Dec;8(1):266-302. doi: 10.1902/annals.2003.8.1.266. PMID: 14971257. 4. Wang HL, Carroll MJ. Guided bone regeneration using bone grafts and collagen membranes. Quintessence Int. 2001 Jul-Aug;32(7):504-15. PMID: 11495562. 5. Wang HL, Al-Shammari KF. Guided tissue regeneration-based root coverage utilizing collagen membranes: technique and case reports. Quintessence Int. 2002 Nov-Dec;33(10):715-21. PMID: 12553614. 6. Elharar F, Rodriguez HJ, Benqué EP, Caffesse RG. Guided tissue regeneration with bioabsorbable and expanded polytetrafluoroethylene barrier membranes in the treatment of naturally occurring periodontal defects in dogs. J Periodontol. 1998 Nov;69(11):1218-28. doi: 10.1902/jop.1998.69.11.1218. PMID: 9848531. 7. Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects. I. Clinical measures. J Periodontol. 1993 Apr;64(4):254-60. doi: 10.1902/jop.1993.64.4.254. PMID: 8483087. 8. Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects. II. Re-entry procedures and bone measures. J Periodontol. 1993 Apr;64(4):261-8. doi: 10.1902/jop.1993.64.4.261. PMID: 8483088. 9. Tonetti MS, Pini Prato G, Williams RC, Cortellini P. Periodontal regeneration of human infrabony defects. III. Diagnostic strategies to detect bone gain. J Periodontol. 1993 Apr;64(4):269-77. doi: 10.1902/jop.1993.64.4.269. PMID: 8483089. 10. Pretzl B, Kim TS, Holle R, Eickholz P. Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. IV. A case series of infrabony defects after 10 years. J Periodontol. 2008 Aug;79(8):1491-9. doi: 10.1902/jop.2008.070571. PMID: 18673000. 11. Cortellini P, Pini-Prato G, Tonetti M. Periodontal regeneration of human infrabony defects (V). Effect of oral hygiene on long-term stability. J Clin Periodontol. 1994 Oct;21(9):606-10. doi: 10.1111/j.1600-051x.1994.tb00751.x. PMID: 7806677. 12. Yen CC, Tu YK, Chen TH, Lu HK. Comparison of treatment effects of guided tissue regeneration on infrabony lesions between animal and human studies: a systematic review and meta-analysis. J Periodontal Res. 2014 Aug;49(4):415-24. doi: 10.1111/jre.12130. Epub 2013 Sep 24. PMID: 24111550. 13. Walters SP, Greenwell H, Hill M, Drisko C, Pickman K, Scheetz JP. Comparison of porous and non-porous teflon membranes plus a xenograft in the treatment of vertical osseous defects: a clinical reentry study. J Periodontol. 2003 Aug;74(8):1161-8. doi: 10.1902/jop.2003.74.8.1161. PMID: 14514229. Bone grafts for periodontal regeneration 1. Rosen PS, Reynolds MA, Bowers GM. The treatment of intrabony defects with bone grafts. Periodontol 2000. 2000 Feb;22:88-103. doi: 10.1034/j.1600-0757.2000.2220107.x. PMID: 11276519. 2. Hanes PJ. Bone replacement grafts for the treatment of periodontal intrabony defects. Oral Maxillofac Surg Clin North Am. 2007 Nov;19(4):499-512, vi. doi: 10.1016/j.coms.2007.06.001. PMID: 18088901. 3. Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A. A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol. 2002;29 Suppl 3:117-35; discussion 160-2. doi: 10.1034/j.1600-051x.29.s3.7.x. PMID: 12787213. 4. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review. Ann Periodontol. 2003 Dec;8(1):227-65. doi: 10.1902/annals.2003.8.1.227. PMID: 14971256. 5. Brunsvold MA, Mellonig JT. Bone grafts and periodontal regeneration. Periodontol 2000. 1993 Feb;1:80-91. PMID: 9673211. 6. Mellonig JT. Autogenous and allogeneic bone grafts in periodontal therapy. Crit Rev Oral Biol Med. 1992;3(4):333-52. doi: 10.1177/10454411920030040201. PMID: 1391415. 7. Rosenberg E, Rose LF. Biologic and clinical considerations for autografts and allografts in periodontal regeneration therapy. Dent Clin North Am. 1998 Jul;42(3):467-90. PMID: 9700450. Biological agents for periodontal regeneration I: Enamel matrix derivative 1. Heden G, Wennström JL. Five-year follow-up of regenerative periodontal therapy with enamel matrix derivative at sites with angular bone defects. J Periodontol. 2006 Feb;77(2):295-301. 2. Heijl L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol. 1997 Sep;24(9 Pt 2):693-6. 3. Heijl L, Heden G, Svärdström G, Ostgren A. Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol. 1997 Sep;24(9 Pt 2):705-14. 4. Jepsen S, Heinz B, Jepsen K, Arjomand M, Hoffmann T, Richter S, Reich E, Sculean A, Gonzales JR, Bödeker RH, Meyle J. A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars. Part I: Study design and results for primary outcomes. J Periodontol. 2004 Aug;75(8):1150-60. 5. Pontoriero R, Wennström J, Lindhe J. The use of barrier membranes and enamel matrix proteins in the treatment of angular bone defects. A prospective controlled clinical study. J Clin Periodontol. 1999 Dec;26(12):833-40. 6. Sculean A, Windisch P, Chiantella GC, Donos N, Brecx M, Reich E. Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study. J Clin Periodontol. 2001 May;28(5):397-403. 7. Yukna RA, Mellonig JT. Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative. A 10-case series. J Periodontol. 2000 May;71(5):752-9. 8. Bosshardt DD. Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels. J Clin Periodontol. 2008 Sep;35(8 Suppl):87-105. 9. Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain(R)) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD003875. 10. Venezia E, Goldstein M, Boyan BD, Schwartz Z. The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis. Crit Rev Oral Biol Med. 2004 Nov 1;15(6):382-402. 11. Zeichner-David M. Regeneration of periodontal tissues: cementogenesis revisited. Periodontol 2000. 2006;41:196-217. 12. Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M, Stavropoulos A, Zhang Y, Trombelli L, Kasaj A, Shirakata Y, Cortellini P, Tonetti M, Rasperini G, Jepsen S, Bosshardt DD. Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol. 2016 Aug;43(8):668-83. doi: 10.1111/jcpe.12546. Epub 2016 May 28. PMID: 26987551. 13. Parashis AO, Polychronopoulou A, Tsiklakis K, Tatakis DN. Enamel matrix derivative in intrabony defects: prognostic parameters of clinical and radiographic treatment outcomes. J Periodontol. 2012 Nov;83(11):1346-52. doi: 10.1902/jop.2012.110551. Epub 2012 Jan 16. PMID: 22248222. 14. Pietruska M, Pietruski J, Nagy K, Brecx M, Arweiler NB, Sculean A. Four-year results following treatment of intrabony periodontal defects with an enamel matrix derivative alone or combined with a biphasic calcium phosphate. Clin Oral Investig. 2012 Aug;16(4):1191-7. doi: 10.1007/s00784-011-0611-2. Epub 2011 Sep 1. PMID: 21881869. 15. Ribeiro FV, Casarin RC, Júnior FH, Sallum EA, Casati MZ. The role of enamel matrix derivative protein in minimally invasive surgery in treating intrabony defects in single-rooted teeth: a randomized clinical trial. J Periodontol. 2011 Apr;82(4):522-32. doi: 10.1902/jop.2010.100454. Epub 2010 Nov 8. PMID: 21054224. Biological agents for periodontal regeneration II: Platelet-rich factors 1. Anitua E, Sánchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007 Nov;28(31):4551-60. doi: 10.1016/j.biomaterials.2007.06.037. Epub 2007 Jul 30. PMID: 17659771. 2. Freymiller EG, Aghaloo TL. Platelet-rich plasma: ready or not? J Oral Maxillofac Surg. 2004 Apr;62(4):484-8. doi: 10.1016/j.joms.2003.08.021. PMID: 15085518. 3. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999 Jul-Aug;14(4):529-35. PMID: 10453668. 4. Anitua EA. Enhancement of osseointegration by generating a dynamic implant surface. J Oral Implantol. 2006;32(2):72-6. doi: 10.1563/736.1. PMID: 16704108. 5. Jung RE, Glauser R, Schärer P, Hämmerle CH, Sailer HF, Weber FE. Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res. 2003 Oct;14(5):556-68. doi: 10.1034/j.1600-0501.2003.00921.x. PMID: 12969359. 6. Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH. Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review. Clin Oral Implants Res. 2008 Jun;19(6):539-45. doi: 10.1111/j.1600-0501.2008.01525.x. Epub 2008 Apr 16. PMID: 18422984. Cellular therapy: Mesenchymal stem cells for periodontal regeneration 1. Zheng C, Chen J, Liu S, Jin Y. Stem cell-based bone and dental regeneration: a view of microenvironmental modulation. Int J Oral Sci. 2019 Aug 19;11(3):23. doi: 10.1038/s41368-019-0060-3. PMID: 31423011; PMCID: PMC6802669. 2. Giannobile WV, Berglundh T, Al-Nawas B, Araujo M, Bartold PM, Bouchard P, Chapple I, Gruber R, Lundberg P, Sculean A, Lang NP, Lyngstadaas P, Kebschull M, Galindo-Moreno P, Schwartz Z, Shapira L, Stavropoulos A, Reseland J. Biological factors involved in alveolar bone regeneration: Consensus report of Working Group 1 of the 15th European Workshop on Periodontology on Bone Regeneration. J Clin Periodontol. 2019 Jun;46 Suppl 21:6-11. doi: 10.1111/jcpe.13130. PMID: 31215113. 3. Sanz M, Dahlin C, Apatzidou D, Artzi Z, Bozic D, Calciolari E, De Bruyn H, Dommisch H, Donos N, Eickholz P, Ellingsen JE, Haugen HJ, Herrera D, Lambert F, Layrolle P, Montero E, Mustafa K, Omar O, Schliephake H. Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. J Clin Periodontol. 2019 Jun;46 Suppl 21:82-91. doi: 10.1111/jcpe.13123. PMID: 31215114. 4. Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. A Cochrane systematic review. Eur J Oral Implantol. 2009 Winter;2(4):247-66. PMID: 20467602. 5. Moreno Sancho F, Leira Y, Orlandi M, Buti J, Giannobile WV, D'Aiuto F. Cell-Based Therapies for Alveolar Bone and Periodontal Regeneration: Concise Review. Stem Cells Transl Med. 2019 Dec;8(12):1286-1295. doi: 10.1002/sctm.19-0183. Epub 2019 Nov 6. PMID: 31692298; PMCID: PMC6877771. 6. Bartold M, Gronthos S, Haynes D, Ivanovski S. Mesenchymal stem cells and biologic factors leading to bone formation. J Clin Periodontol. 2019 Jun;46 Suppl 21:12-32. doi: 10.1111/jcpe.13053. PMID: 30624807. 7. Ouchi T, Nakagawa T. Mesenchymal stem cell-based tissue regeneration therapies for periodontitis. Regen Ther. 2020 Jan 15;14:72-78. doi: 10.1016/j.reth.2019.12.011. PMID: 31970269; PMCID: PMC6962327. 8. Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A. A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol. 2002;29 Suppl 3:117-35; discussion 160-2. doi: 10.1034/j.1600-051x.29.s3.7.x. PMID: 12787213. 9. Trombelli L, Farina R. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. J Clin Periodontol. 2008 Sep;35(8 Suppl):117-35. doi: 10.1111/j.1600-051X.2008.01265.x. PMID: 18724846. 10. Weinreb M, Nemcovsky CE. In vitro models for evaluation of periodontal wound healing/regeneration. Periodontol 2000. 2015 Jun;68(1):41-54. doi: 10.1111/prd.12079. PMID: 25867978. 11. Apatzidou DA, Bakopoulou AA, Kouzi-Koliakou K, Karagiannis V, Konstantinidis A. A tissue-engineered biocomplex for periodontal reconstruction. A proof-of-principle randomized clinical study. J Clin Periodontol. 2021 Aug;48(8):1111-1125. doi: 10.1111/jcpe.13474. Epub 2021 May 14. PMID: 33899259. Tissue engineering: Application in maxillofacial surgery - Bio-printing; organoids on a chip 1. Gjerde C, Mustafa K, Hellem S, Rojewski M, Gjengedal H, Yassin MA, Feng X, Skaale S, Berge T, Rosen A, Shi XQ, Ahmed AB, Gjertsen BT, Schrezenmeier H, Layrolle P. Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Stem Cell Res Ther. 2018 Aug 9;9(1):213. doi: 10.1186/s13287-018-0951-9. PMID: 30092840; PMCID: PMC6085689. 2. Freeman FE, Brennan MÁ, Browe DC, Renaud A, De Lima J, Kelly DJ, McNamara LM, Layrolle P. A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect. Front Bioeng Biotechnol. 2020 Mar 31;8:230. doi: 10.3389/fbioe.2020.00230. PMID: 32296687; PMCID: PMC7137087. 3. Freeman FE, Schiavi J, Brennan MA, Owens P, Layrolle P, McNamara LM. * Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells. Tissue Eng Part A. 2017 Dec;23(23-24):1466-1478. doi: 10.1089/ten.TEA.2017.0052. Epub 2017 Oct 12. PMID: 28756737. 4. Brennan MÁ, Renaud A, Amiaud J, Rojewski MT, Schrezenmeier H, Heymann D, Trichet V, Layrolle P. Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate. Stem Cell Res Ther. 2014 Oct 13;5(5):114. doi: 10.1186/scrt504. PMID: 25311054; PMCID: PMC4445278. 5. Vidal L, Kampleitner C, Krissian S, Brennan MÁ, Hoffmann O, Raymond Y, Maazouz Y, Ginebra MP, Rosset P, Layrolle P. Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds. Sci Rep. 2020 Apr 27;10(1):7068. doi: 10.1038/s41598-020-63742-w. PMID: 32341459; PMCID: PMC7184564. 6. Vidal L, Kampleitner C, Brennan MÁ, Hoornaert A, Layrolle P. Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing. Front Bioeng Biotechnol. 2020 Feb 12;8:61. doi: 10.3389/fbioe.2020.00061. PMID: 32117940; PMCID: PMC7029716. Minimally Invasive Surgical Technique (MIST) I 1. Cortellini P, Prato GP, Tonetti MS. The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. Int J Periodontics Restorative Dent. 1999 Dec;19(6):589-99. PMID: 10815597. 2. Cortellini P, Prato GP, Tonetti MS. The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures. J Periodontol. 1995 Apr;66(4):261-6. doi: 10.1902/jop.1995.66.4.261. PMID: 7782979. 3. Cortellini P, Tonetti MS. Focus on intrabony defects: guided tissue regeneration. Periodontol 2000. 2000 Feb;22:104-32. doi: 10.1034/j.1600-0757.2000.2220108.x. PMID: 11276509. 4. Cortellini P, Tonetti MS. A minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: a novel approach to limit morbidity. J Clin Periodontol. 2007 Jan;34(1):87-93. doi: 10.1111/j.1600-051X.2006.01020.x. PMID: 17243998. 5. Cortellini P, Tonetti MS. Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects. J Clin Periodontol. 2009 Feb;36(2):157-63. doi: 10.1111/j.1600-051X.2008.01352.x. PMID: 19207892. 6. Harrel SK, Nunn ME. Longitudinal comparison of the periodontal status of patients with moderate to severe periodontal disease receiving no treatment, non-surgical treatment, and surgical treatment utilizing individual sites for analysis. J Periodontol. 2001 Nov;72(11):1509-19. doi: 10.1902/jop.2001.72.11.1509. PMID: 11759862. 7. Harrel SK, Wilson TG Jr, Nunn ME. Prospective assessment of the use of enamel matrix derivative with minimally invasive surgery: 6-year results. J Periodontol. 2010 Mar;81(3):435-41. doi: 10.1902/jop.2009.090393. PMID: 20192871. 8. Trombelli L, Farina R, Franceschetti G, Calura G. Single-flap approach with buccal access in periodontal reconstructive procedures. J Periodontol. 2009 Feb;80(2):353-60. doi: 10.1902/jop.2009.080420. PMID: 19186978. 9. Apatzidou DA, Bakopoulou AA, Kouzi-Koliakou K, Karagiannis V, Konstantinidis A. A tissue-engineered biocomplex for periodontal reconstruction. A proof-of-principle randomized clinical study. J Clin Periodontol. 2021 Aug;48(8):1111-1125. doi: 10.1111/jcpe.13474. Epub 2021 May 14. PMID: 33899259. Minimally Invasive Surgical Technique (MIST) II 1. Aimetti M, Ferrarotti F, Mariani G, Fratini A, Giraudi M, Romano F. Enamel Matrix Derivative Proteins in Combination with a Flapless Approach for Periodontal Regeneration of Intrabony Defects: A 2-Year Prospective Case Series. Int J Periodontics Restorative Dent. 2016 Nov/Dec;36(6):797-805. doi: 10.11607/prd.2842. PMID: 27740640. 2. Aimetti M, Ferrarotti F, Mariani GM, Romano F. A novel flapless approach versus minimally invasive surgery in periodontal regeneration with enamel matrix derivative proteins: a 24-month randomized controlled clinical trial. Clin Oral Investig. 2017 Jan;21(1):327-337. doi: 10.1007/s00784-016-1795-2. Epub 2016 Apr 5. PMID: 27044318. 3. Cortellini P, Nieri M, Prato GP, Tonetti MS. Single minimally invasive surgical technique with an enamel matrix derivative to treat multiple adjacent intra-bony defects: clinical outcomes and patient morbidity. J Clin Periodontol. 2008 Jul;35(7):605-13. doi: 10.1111/j.1600-051X.2008.01242.x. Epub 2008 May 11. PMID: 18476997. 4. Cortellini P, Tonetti MS. Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects. J Clin Periodontol. 2009 Feb;36(2):157-63. doi: 10.1111/j.1600-051X.2008.01352.x. PMID: 19207892. 5. Cortellini P, Tonetti MS. Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects. J Clin Periodontol. 2011 Apr;38(4):365-73. doi: 10.1111/j.1600-051X.2011.01705.x. Epub 2011 Feb 8. PMID: 21303402. 6. Cortellini P, Tonetti MS. Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects. J Clin Periodontol. 2011 Apr;38(4):365-73. doi: 10.1111/j.1600-051X.2011.01705.x. Epub 2011 Feb 8. PMID: 21303402. 7. Harrel SK, Abraham CM, Rivera-Hidalgo F, Shulman JD, Nunn ME. Videoscope-assisted minimally invasive periodontal surgery (V-MIS). J Clin Periodontol. 2014 Sep;41(9):900-7. doi: 10.1111/jcpe.12294. Epub 2014 Aug 7. PMID: 25039580. 8. Mishra A, Avula H, Pathakota KR, Avula J. Efficacy of modified minimally invasive surgical technique in the treatment of human intrabony defects with or without use of rhPDGF-BB gel: a randomized controlled trial. J Clin Periodontol. 2013 Feb;40(2):172-9. doi: 10.1111/jcpe.12030. Epub 2012 Nov 21. PMID: 23167912. 9. Schincaglia GP, Hebert E, Farina R, Simonelli A, Trombelli L. Single versus double flap approach in periodontal regenerative treatment. J Clin Periodontol. 2015 Jun;42(6):557-66. doi: 10.1111/jcpe.12409. Epub 2015 May 29. PMID: 25924545.  Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Beglundh T, Sculean A, Tonetti MS; EFP Workshop Participants and Methodological Consultants. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline. J Clin Periodontol. 2020 Jul;47 Suppl 22(Suppl 22):4-60. doi: 10.1111/jcpe.13290. Erratum in: J Clin Periodontol. 2021 Jan;48(1):163. PMID: 32383274; PMCID: PMC7891343.