Learning Outcomes
Upon completion of this course the student is expected to:
- be aware of the applications of transport phenomena (fluid flow and mixing, heat transfer, mass transfer) to bio-processes, as well as the relevant mass and energy balances, the basic principles of kinetics in biological systems (self-catalytic, enzymatic, heterogeneous reactions, cell growth , enzyme deactivation, energy metabolism)
- know the operating principles of the main types of bioreactors (discontinuous, plunger flow and full mixing).
- be able to solve related combinatory exercises referred to in the preceding articles.
- be familiar with the main "downstream processing" methods, which refer to biodegradation, ie isolation and purification of biotechnological products.
Course Content (Syllabus)
Applications of transport phenomena (fluid flow and mixing, heat transfer, mass transfer) in bio-processes. Mass and energy balances. Kinetics in biological systems (auto-catalytic, enzymatic, heterogeneous reactions, cell growth, enzyme inactivation, energy metabolism). Operation and types of bioreactors (discontinuous, plunger flow and full mix). Downstream processing. Separation - isolation - purification of biotechnologically produced products. Combined biodegradation processes. Flow charts.
Course Bibliography (Eudoxus)
1. Ζουμπούλης Α. , Μάτης Κ., 2010, Διεργασίες στη Βιοτεχνολογία, εκδ. Τζιόλας, 264 σσ.
2. Λιακοπούλου - Κυριακίδου, Μ., Στοιχεία Βιοτεχνολογίας, Εκδόσεις Γράφημα, Θεσσαλονίκη, 1995.
Additional bibliography for study
1. Doran P.M., 1998, Bioprocess Engineering Principles, Academic Press, Sydney.
2. Bailey J.E. and Ollis D.F., 1986, Biochemical Engineering Fundamentals, McGraw-Hill, Singapore.
βλ. ακόμα στο Blackboard