Curriculum Vitae

Konstantinos Zacharis

Assistant Professor, School of Pharmacy

Personal Information

- 2310997663
- 2310997652
czacharis@pharm.auth.gr
Scopus ID6506879670
https://orcid.org/0000-0001-9362-8523
Γνωστικό Αντικείμενο:
Φαρμακευτική Ανάλυση
Επιστημονική Ειδίκευση:
- Χημεία
- Φαρμακευτική

Course Work

Courses of Winter semester of 2023–24 academic year

	SCHOOL OF PHARMACY
23	PHARMACEUTICAL ANALYSIS I
ΝΠ18-22	Pharmaceutical Analysis I
ΝΠ18-Δ1	Diploma Thesis 1/2
ΝΠ18-Δ2	Diploma Thesis 2/2

	POSTGRADUATE STUDIES PROGRAMME OF THE SCHOOL OF PHARMACY "INDUSTRIAL PHARMACY"
ΠΜΣΒΦ-002	Introduction to Industrial Pharmaceutical Analysis
ΠΜΣΒΦ-004	1st stage of elaboration of diploma thesis
ΠΜΣΒΦ-010	3rd stage of elaboration of diploma thesis

	POSTGRADUATE STUDIES PROGRAMME OF THE SCHOOL OF PHARMACY "PHARMACEUTICAL TECHNOLOGY"
ΠΜΣΦΤ-007	Planning and Authoring a Research Proposal
ΠΜΣΦΤ-008	Postgraduate Level Laboratory Research I
ΠΜΣΦΤ-009	Postgraduate Level Laboratory Research II
ΠΜΣΦΤ-010	Preparation and Presentation of Graduate Diploma Thesis
ΠΜΣΦΤ-011	Quality Control of Pharmaceutical Products

Theses Supervised

Student Theses within AUTh

In progress

Undergraduate

Επικύρωση αναλυτικής μεθόδου UV-Vis για την μελέτη διαλυτοποίηση φουροσεμίδης σε δισκία της. Σύγκριση πρωτότυπου και γενόσημου σκευάσματος.
Προσδιορισμός ραμιπρίλης με φασματοφωτομετρία UV-VIS σε δισκία και μελέτη διαλυτοποίησης
Φασματοφωτομετρικός προσδιορισμός σιμβαστατίνης σε δισκία και έλεγχος ομοιομορφίας.
Επικύρωση αναλυτικής μεθόδου UV-Vis για τον προσδιορισμό καπτοπρίλης σε δισκία της και έλεγχος ομοιομορφίας
Επικύρωση μεθόδων HPLC για τον προσδιορισμό αμφοτερικίνης Β σε βιολογικά δείγματα μετά από μικροεκχύλιση
Επικύρωση αναλυτικής μεθόδου UVV για τον προσδιορισμό εναλαπρίλης σε δισκία της και μελέτη του ρυθμού διαλυτοποίησής τους.

Doctoral

Ανάπτυξη βιοαναλυτικών μεθόδων με χρήση μικροεκχύλισης στερεού μέσου σε συνδυασμό με παραγωγοποίηση

Postgraduate

Συνδυασμός παραγωγοποίησης και μικροεκχύλισης με κάψουλα (capsule phase microextraction) για την ανάλυση λανρεοτίδης σε ούρα με HPLC

2022–2023

Postgraduate

Ανάπτυξη και επικύρωση αναλυτικής μεθόδου χρωματογραφίας υγρού για τον προσδιορισμό αντισταμινικών φαρμακευτικών ενώσεων σε ούρα ανθρώπου μετά από μικροεκχύλιση FPSE
Προσδιορισμός βιταμίνης Β12 σε δείγματα σιέλου με HPLC μετά από εκχύλιση προσρόφησης με υφασμάτινο μέσο
Εφαρμογή μικροεκχύλισης με κάψουλα (capsule phase microextraction) για τον προσδιορισμό στατινών σε ούρα ανθρώπου με HPLC

Undergraduate

Ανάπτυξη αναλυτικής μεθόδου για τον προσδιορισμό της πρόσμιξης ιμιδαζόλιο στη δραστική κιτρική σιλδεναφίλη και σε δισκία της με τη χρήση HPLC
Ανάλυση και έλεγχος ομοιομορφίας δισκίων λισινοπρίλης με υγρή χρωματογραφία Υψηλής απόδοσης.
Επικύρωση αναλυτικής μεθόδου HPLC υδρόφιλων αλληλεπιδράσεων για τον προσδιορισμό ιμιδαζολίου στη δραστικά φαρμακευτική ένωση σιλδεναφίλη
Εφαρμογή αναλυτικής μεθόδου φασμαφωτομετρίας UV για τον προσδιορισμό καπτοπρίλης σε δισκία και μελέτη διαλυτοποίησης
Προσδιορισμός πιροξικάμης και μελοξικάμης σε ούρα ανθρώπου με HPLC μετά από μικροεκχύλιση υγρού-υγρού με την επίδραση άλατος.
Ομογενής μικροεκχύλιση υγρού-υγρού σε συνθήκες υψηλής αλατότητας για τον προσδιορισμό της νιμεσουλίδης σε ούρα ανθρώπου, με τη βοήθεια πειραματικού σχεδιασμού

2021–2022

Postgraduate

Ανάπτυξη και επικύρωση μεθόδου προσδιορισμού έξι β-αναστολέων σε δείγματα ορού αίματος και ούρων με UHPLC-MS/MS, μετά από εκχύλιση FPSE
"Χρήση της τεχνικής εκχύλισης FPSE στον προσδιορισμό ριμανταδίνης, αμανταδίνης και μεμαντίνης σε βιολογικά υγρά με LC-MS"
Ανάπτυξη και επικύρωση αναλυτικής μεθόδου HPLC για τον προσδιορισμό δοξορουβικίνης και των μεταβολιτών της σε πλάσμα αρουραίου μετά από μικροεκχύλιση με κάψουλα (CPME)
Ανάπτυξη και επικύρωση αναλυτικής μεθόδου με χρήση UHPLC-PDA για τον προσδιορισμό ιβουπροφαίνης σε προσομοιωμένα γαστροεντερικά δείγματα

Undergraduate

Ανάπτυξη αναλυτικής μεθόδου μικροεκχύλισης υγρού-υγρού με τη βοήθεια άλατος για τον προσδιορισμό φαρμακευτικών αζολών σε ανθρώπινα ούρα με HPLC

2019–2020

Postgraduate

"Ανάπτυξη ομογενούς εκχύλισης υγρού-υγρού για τον προσδιορισμό δοξορουβικίνης σε δείγματα ούρων με χρωματογραφία υγρού υπερυψηλής πίεσης με φθορισμομετρική ανίχνευση"
Ανάπτυξη και επικύρωση αναλυτικής μεθόδου για τον προσδιορισμό της γενοτοξικής πρόσμιξης "υδραζίνη", σε φαρμακευτικά σκευάσματα αλλοπουρινόλης με UHPLC-FLD

Research Projects

Coordinator
2022–2023	Ανάπτυξη και εφαρμογή διάταξης μικροεκχύλισης σε συνδυασμό με παραγωγοποίηση για την ανάλυση λανρεοτίδης σε βιολογικά υγρά με HPLC-FLD
2022–2024	Ανάπτυξη και εφαρμογή αναλυτικών μεθόδων σε φαρμακευτικά προϊόντα
2022–2022	«Ανάπτυξη και επικύρωση αναλυτικής μεθόδου προσδιορισμού προσμίξεων της δραστικής ένωσης florfenicol. Ανάλυση δειγμάτων μελέτης σταθερότητας τελικών προϊόντων florfenicol και praziquantel
2021–2022	Ανάπτυξη και επικύρωση μεθόδων ανάλυσης των δραστικών ενώσεων florfenicol και praziquantel σε σκευάσματα για κτηνιατρική χρήση

Participant
2020–2023	Διασπειρόμενοι νανοκρύσταλλοι σιλδεναφίλης
2018–2024	Πρόγραμμα Μεταπτυχιακών Σπουδών: Βιομηχανική φαρμακευτική
2014–2017	Σεμινάρια Κατάρτισης σε προχωρημένες χρωματογραφικές μεθόδους
2011–2013	Ευρωπαϊκή εκπαίδευση για τεχνικούς χημικούς εργαστηρίων
2010–2014	Υποτροφίες Αριστείας - Βραβεία Αριστείας & Καινοτομίας από την Επιτροπή Ερευνών του Α.Π.Θ
2008–2011	Κέντρο προκλινικού ελέγχου φαρμάκων.
2007–2008	Προηγμένα υλικά για βιοτεχνολογικές και βιοϊατρικές εφαρμογές. Πολυμερή μοριακής αποτύπωσης και pH-θερμοαντιδρώντα μικρο/νανοσφαιρίδια για την ανάπτυξη νέων συστημάτων χορήγησης φαρμάκων και βιο-αναλυτικών τεχνικών
2007–2023	Αμοιβές μελών ΔΕΠ (ΔΙΕΘΝΕΣ ΠΑΝΕΠΙΣΤΗΜΙΟ ΕΛΛΑΔΟΣ/ (ΔΙΕΘΝΕΣ ΠΑΝΕΠΙΣΤΗΜΙΟ ΕΛΛΑΔΟΣ/ ΑΤΕΙ ΘΕΣΣΑΛΟΝΙΚΗΣ/ ΤΕΙ ΑΝΑΤΟΛΙΚΗΣ ΜΑΚΕΔΟΝΙΑΣ ΘΡΑΚΗΣ/ ΤΕΙ ΚΕΝΤΡΙΚΗΣ ΜΑΚΕΔΟΝΙΑΣ)
2006–2008	Πολυμερή μονολιθικά υλικά ως στατική φάση για τριχοειδή χρωματοδραφία και τριχοειδή ηλεκτροχρωματογραφία. Εφαρμογή στο διαχωρισμό εναντιομερών βιομορίων
2003–2005	Παραγωγή και χρήση νέων υλικών για βιοδιαχωρισμούς. Ανάπτυξη συστημάτων κατεργασίας δείγματος σε ροή
2002–2006	ΗΡΑΚΛΕΙΤΟΣ: Αυτοματισμός (on-line) στην προκατεργασία και ανάλυση δειγμάτων με την τεχνική της διαδοχικής έγχυσης του δείγματος (sequential injection analysis-SIA) σε συνδυασμό με την υγρή χρωματογραφία υψηλής πίεσης (HPLC)
2002–2015	Έλεγχος ποιότητας πόσιμου νερού του Δήμου Θέρμης

Publications

(2023)

Journal Article

Ntontis Stefanos, Tsanaktsidou Eleni, Tzanavaras Paraskevas, Kachrimanis Kyriakos, Markopoulou Aikaterini, Zacharis Konstantinos (2023). Analytical quality by design approach for the determination of imidazole in sildenafil API and its formulations using zwitterionic HILIC stationary phase. Journal of Pharmaceutical and Biomedical Analysis. vol.224 no.C p.115186.
Tsiasioti Apostolia, Zacharis Konstantinos, Tzanavaras Paraskevas (2023). Development and evaluation of pulsed – Post column derivatization in liquid chromatography as a concept to minimize reagent consumption. Journal of Chromatography A. vol.1690 no.C p.463791.
Tsiasioti Apostolia, Zacharis Konstantinos, Tzanavaras Paraskevas (2023). Determination of Free Histidine in Complex Hair Care Products with Minimum Sample Preparation Using Cation-Exchange Chromatography and Post Column Derivatization. Molecules. vol.28 no.2 p.888.

(2022)

Journal Article

Asimakopoulou Evmorfia, Manousi Natalia, Anaxagorou Nikoleta, Kabir Abuzar, Furton Kenneth G, Zacharis Konstantinos (2022). Fabric Phase Sorptive Extraction Combined with HPLC-UV for the Quantitation of Amphotericin B in Human Urine. Chemosensors. vol.10 no.12 p.537.
Doumtsi Antigoni, Manousi Natalia, Karavasili Christina, Fatouros Dimitrios, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). A simple and green liquid chromatography method for the determination of ibuprofen in milk-containing simulated gastrointestinal media for monitoring the dissolution studies of three-dimensional-printed formulations. Journal of Separation Science. vol.45 no.21 p.3955-3965.
Gkantiri Anna-Maria, Tsiasioti Apostolia, Zacharis Konstantinos, Tzanavaras Paraskevas (2022). HPLC method with post-column derivatization for the analysis of endogenous histidine in human saliva validated using the total-error concept. Amino Acids. vol.54 no.3 p.399–409.
Lili Chrystalla, Manousi Natalia, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). Green homogeneous liquid-liquid microextraction at high salinity conditions for the determination of nimesulide in human urine with the aid of experimental design. Sustainable Chemistry and Pharmacy. vol.29 p.Article number: 100797 (12 pages).
Mamounas Georgios, Manousi Natalia, Kabir Abuzar, Furton Kenneth G, Mystridis Georgios A, Vizirianakis Ioannis, Zacharis Konstantinos (2022). Designing an “all-in-one” microextraction capsule device for the liquid chromatographic-fluorescence determination of doxorubicin and its metabolites in rat plasma. Journal of Chromatography A. vol.1680 no.C p.463432.
Manousi Natalia, Korpeti Anastasia, Kabir Abuzar, Furton Kenneth G, Zacharis Konstantinos (2022). Capsule Phase Microextraction Combined with Chemometrics for the HPLC Determination of Amphotericin B in Human Serum. Separations. vol.9 no.12 p.433.
Manousi Natalia, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological materials: An updated review. Journal of Pharmaceutical & Biomedical Analysis. vol.219 p.Article number: 114921 (15 pages).
Manousi Natalia, Karavasili Christina, Fatouros Dimitrios, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). Development and Validation of an HPLC-UV Method for the Dissolution Studies of 3D-Printed Paracetamol Formulations in Milk-Containing Simulated Gastrointestinal Media. Pharmaceuticals. vol.15 no.6 p.Article number: 755 (15 pages).
Manousi Natalia, Kabir Abuzar, Furton Kenneth G, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). In situ synthesis of monolithic sol–gel polyethylene glycol-based sorbent encapsulated in porous polypropylene microextraction capsules and its application for selective extraction of antifungal and anthelmintic drugs from human urine. Microchemical Journal. vol.180 p.Article number: 107594 (11 pages).
Manousi Natalia, Kabir Abuzar, Furton Kenneth G, Samanidou Viktoria, Zacharis Konstantinos (2022). Exploiting the capsule phase microextraction features in bioanalysis: Extraction of ibuprofen from urine samples. Microchemical Journal. vol.172 p.Article number: 106934 (12 pages).
Mitsika Elena E, Christophoridis Christophoros, Kouinoglou Nikolaos, Lazaridis Nikolaos, Zacharis Konstantinos, Fytianos Konstantinos (2022). Optimized Photo-Fenton degradation of psychoactive pharmaceuticals alprazolam and diazepam using a chemometric approach—Structure and toxicity of transformation products. Journal of Hazardous Materials. vol.403 p.Article Number: 123819 (16 pages).
Papavasileiou Kalliopi, Tsiasioti Apostolia, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). HPLC Determination of Colistin in Human Urine Using Alkaline Mobile Phase Combined with Post-Column Derivatization: Validation Using Accuracy Profiles. Molecules. vol.27 no.11 p.Article number: 3489 (14 pages).
Sidiropoulou Georgia, Kabir Abuzar, Furton Kenneth G, Kika Fotini S, Fytianos Konstantinos, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). Combination of fabric phase sorptive extraction with UHPLC-ESI-MS/MS for the determination of adamantine analogues in human urine. Microchemical Journal. vol.176 p.Article number: 107250 (11 pages).
Tsamis Vasileios, Tsanaktsidou Eleni, Karavasili Christina, Zacharis Konstantinos, Bouropoulos Nikolaos, Fatouros Dimitrios, Markopoulou Aikaterini (2022). Development and validation of HPLC-DAD and LC-(ESI)/MS methods for the determination of sulfasalazine, mesalazine and hydrocortisone 21-acetate in tablets and rectal suppositories: In vitro and ex vivo permeability studies. Journal of Chromatography B. vol.1198 no.C p.123246.
Tsanaktsidou Eleni, Kanata Lamprini, Almpani Sofia, Zacharis Konstantinos, Markopoulou Aikaterini (2022). Development and Validation of an HPLC-FLD Method for the Determination of NDMA and NDEA Nitrosamines in Lisinopril Using Pre-Column Denitrosation and Derivatization Procedure. Separations. vol.9 no.11 p.347.
Tsanaktsidou Eleni, Markopoulou Aikaterini, Tzanavaras Paraskevas, Zacharis Konstantinos (2022). Homogeneous liquid phase microextraction using hydrophilic media for the determination of fluoroquinolones in human urine using HPLC-FLD. Microchemical Journal. vol.172 no.part A p.Article number: 106906 (10 pages).
Tsiasioti Apostolia, Zacharis Konstantinos, Tzanavaras Paraskevas (2022). Single-Step Hydrolysis and Derivatization of Homocysteine Thiolactone Using Zone Fluidics: Simultaneous Analysis of Mixtures with Homocysteine Following Separation by Fluorosurfactant-Modified Gold Nanoparticles. Molecules. vol.27 no.7 p.Article number: 2040 (9 pages).
Tsiasioti Apostolia, Georgiadou Eirini, Zacharis Konstantinos, Tzanavaras Paraskevas (2022). Development and validation of a direct HPLC method for the determination of salivary glutathione disulphide using a core shell column and post column derivatization with o-phthalaldehyde. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. vol.1197 p.Article number: 123216 (6 pages).
Tzanavaras Paraskevas, Chatzitaki Aikaterini-Theodora, Karavasili Christina, Sarigiannis Yiannis, Fatouros Dimitrios, Zacharis Konstantinos (2022). Analytical quality-by-design optimization of UHPLC method for the analysis of octreotide release from a peptide-based hydrogel in-vitro. Journal of Pharmaceutical & Biomedical Analysis. vol.214 p.Article number: 114699 (12 pages).

(2021)

Journal Article

Christophoridis Christophoros, Veloutsou Sofia, Mitsika Elena, Zacharis Konstantinos, Christia Christina, Raikos Nikolaos, Fytianos Konstantinos (2021). Determination of illicit drugs and psychoactive pharmaceuticals in wastewater from the area of Thessaloniki (Greece) using LC–MS/MS: estimation of drug consumption. Environmental Monitoring and Assessment. vol.193 no.5 p.Article number: 249 (15 pages).
Karakosta Theano D, Tzanavaras Paraskevas, Zacharis Konstantinos (2021). Development and Validation of an Automated Zone Fluidics-Based Sensor for In Vitro Dissolution Studies of Captopril Using Total Error Concept. Molecules. vol.26 no.4 p.Article number: 824 (13 pages).
Kouti Eirini, Tsiasioti Apostolia, Zacharis Konstantinos, Tzanavaras Paraskevas (2021). Specific determination of histamine in cheese and cured meat products by ion chromatography coupled to fluorimetric detection. Microchemical Journal. vol.168 p.Article number: 106513 (8 pages).
Manousi Natalia, Plastiras Orfeas-Evangelos, Kalogiouri Natasa P, Zacharis Konstantinos, Zachariadis Georgios (2021). Metal-Organic Frameworks in Bioanalysis: Extraction of Small Organic Molecules. Separations. vol.8 no.5 p.Article number: 60 (21 pages).
Mazaraki Konstantina, Kabir Abuzar, Furton Kenneth G, Fytianos Konstantinos, Samanidou Viktoria, Zacharis Konstantinos (2021). Fast fabric phase sorptive extraction of selected β-blockers from human serum and urine followed by UHPLC-ESI-MS/MS analysis. Journal of Pharmaceutical & Biomedical Analysis. vol.199 p.Article number: 114053 (8 pages).
Ouranidis Andreas, Tsiaxerli Anastasia, Vardaka Elisavet, Markopoulou Aikaterini, Zacharis Konstantinos, Nikolaou Ioannis, Hatzichristou Dimitrios, Haidich Anna-Bettina, Kostomitsopoulos Nikolaos, Kachrimanis Kyriakos (2021). Sildenafil 4.0—Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era. Pharmaceuticals. vol.14 no.4 p.365.
Partheniadis Ioannis, Nikolakakis Ioannis, Zacharis Konstantinos, Kachrimanis Kyriakos, Al-Zoubi Nizar (2021). Co-Spray Drying of Paracetamol and Propyphenazone with Polymeric Binders for Enabling Compaction and Stability Improvement in a Combination Tablet. Pharmaceutics. vol.13 no.8 p.1259.
Stampina Eirini, Tsiasioti Apostolia, Klimatsaki Kalliopi, Zacharis Konstantinos, Tzanavaras Paraskevas (2021). Determination of histidine in human serum and urine by cation exchange chromatography coupled to selective on-line post column derivatization. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. vol.1173 p.Article number: 122697 (6 pages).
Xenikakis Iakovos, Tsongas Konstantinos, Tzimtzimis Emmanouil K, Zacharis Konstantinos, Theodoroula Nikoleta, Kalogianni Eleni P, Demiri Efterpi, Vizirianakis Ioannis, Tzetzis Dimitrios, Fatouros Dimitrios (2021). Fabrication of hollow microneedles using liquid crystal display (LCD) vat polymerization 3D printing technology for transdermal macromolecular delivery. International Journal of Pharmaceutics. vol.597 no.C p.120303.

(2020)

Journal Article

Alevridis Antonios, Tsiasioti Apostolia, Zacharis Konstantinos, Tzanavaras Paraskevas (2020). Fluorimetric Method for the Determination of Histidine in Random Human Urine Based on Zone Fluidics. Molecules. vol.25 no.7 p.Article number: 1665 (11 pages).
Christofi Marlen, Markopoulou Aikaterini, Tzanavaras Paraskevas, Zacharis Konstantinos (2020). UHPLC-fluorescence method for the determination of trace levels of hydrazine in allopurinol and its formulations: Validation using total-error concept. Journal of Pharmaceutical & Biomedical Analysis. vol.187 p.Article number: 113354 (8 pages).
Karavasili C, Andreadis I.I, Tsantarliotou Maria, Taitzoglou Ioannis, Chatzopoulou P, Katsantonis D, Zacharis Konstantinos, Markopoulou Aikaterini, Fatouros Dimitrios (2020). Self-Nanoemulsifying Drud Delivery Systems (SNEDDS) containing rice bran oil for enhanced fenofibrate oral delivery: In vitro digestion, ex vivo permeability, and in vivo bioavailability studies. AAPS PharmSciTech. vol.21 no.6.
Manousi Natalia, Tzanavaras Paraskevas, Zacharis Konstantinos (2020). Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview. Molecules. vol.25 no.9 p.Article number: 2096 (32 pages).
Stratigou Ioanna-Chrysoula, Tsiasioti Apostolia, Tzanavaras Paraskevas, Markopoulou Aikaterini, Fytianos Konstantinos, Zacharis Konstantinos (2020). Homogeneous liquid liquid extraction using salt as mass separating agent for the ultra high pressure liquid chromatographic determination of doxorubicin in human urine. Microchemical Journal. vol.158 p.Article number: 105260 (10 pages).
Tsanaktsidou Eleni, Karavasili Christina, Zacharis Konstantinos, Fatouros Dimitrios, Markopoulou Aikaterini (2020). Partial Least Square Model (PLS) as a Tool to Predict the Diffusion of Steroids Across Artificial Membranes. Molecules. vol.25 no.6 p.1387.
Tsiasioti Apostolia, Iakovidou Ifigenia, Zacharis Konstantinos, Tzanavaras Paraskevas (2020). Automated fluorimetric sensor for glutathione based on zone fluidics. Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy. vol.229 p.Article number: 117963 (6 pages).
Tsiasioti Apostolia, Zacharis Konstantinos, Zotou Anastasia-Stella, Tzanavaras Paraskevas (2020). Study of the oxidative forced degradation of Glutathione in its nutraceutical formulations using Zone Fluidics and Green Liquid Chromatography. Separations. vol.7 no.1 p.Article number: 16 (12 pages).
Tzanavaras Paraskevas, Themistokleous Stefanos, Zacharis Konstantinos (2020). Automated fluorimetric determination of the genotoxic impurity hydrazine in allopurinol pharmaceuticals using zone fluidics and on-line solid phase extraction. Journal of Pharmaceutical & Biomedical Analysis. vol.177 p.Article number: 112887 (8 pages).
Zacharis Konstantinos, Tzanavaras Paraskevas (2020). Trace analysis of rimantadine in human urine after dispersive liquid liquid microextraction followed by liquid chromatography–post column derivatization. Journal of Separation Science. vol.43 no.3 p.631-638.
Zacharis Konstantinos, Tzanavaras Paraskevas (2020). Editorial: Solid-Phase Microextraction. Molecules. vol.25 no.2 p.Article number: 379 (4 pages).

(2019)

Journal Article

Tzanavaras Paraskevas, Papadimitriou Sofia, Zacharis Konstantinos (2019). Automated Stopped-Flow Fluorimetric Sensor for Biologically Active Adamantane Derivatives Based on Zone Fluidics. Molecules. vol.24 no.21 p.Article number: 3975 (10 pages).

(2018)

Journal Article

Gioti Efthymia G, Koftis Theocharis V, Neokosmidis Efstratios, Vastardi Elli, Kotoulas Stefanos S, Trakossas Sakellarios, Tsatsas Theodoros, Anagnostaki Elizabeth E, Panagiotidis Theodoros D, Zacharis Konstantinos, Tolika Evanthia P, Varvogli Anastasia Aikaterini C, Andreou Thanos, Gallos Ioannis (2018). A new scalable synthesis of entecavir. Tetrahedron. vol.74 no.4 p.519-527.

(2017)

Journal Article

Stathakis Christos, Gkizis Petros, Alexandraki E.S, Trakossas S, Terzidis M, Neokosmidis E, Zacharis Konstantinos, Vasiliadou Christina, Vastardi E, Andreou T, Zitrou A, Varvogli A.-A, Koftis T.V (2017). (Chloromethyl)dimethylchlorosilane-KF: A Two-Step Solution to the Selectivity Problem in the Methylation of a Pyrimidone Intermediate en Route to Raltegravir. Organic Process Research and Development. vol.21 no.9 p.1413-1418.

(2016)

Journal Article

Gougoutsa Chrysa, Christophoridis Christophoros, Zacharis Konstantinos, Fytianos Konstantinos (2016). Assessment, modeling and optimization of parameters affecting the formation of disinfection by-products in water. Environmental Science & Pollution Research. vol.23 no.16 p.16620–16630.

(2014)

Journal Article

Tzanavaras Paraskevas, Zacharis Konstantinos (2014). Automated Fluorimetric Assay for Baclofen After On-line Derivatization with o-phthalaldehyde Based on the Sequential Injection Principle. Current Analytical Chemistry. vol.10 no.3 p.298-304.

(2013)

Journal Article

Tsardaka E.-C, Zacharis Konstantinos, Tzanavaras Paraskevas, Zotou Anastasia-Stella (2013). Determination of glutathione in baker's yeast by capillary electrophoresis using methyl propiolate as derivatizing reagent. Journal of Chromatography A. vol.1300 p. 204–208.
Zacharis Konstantinos, Tzanavaras Paraskevas (2013). Liquid chromatography coupled to on-line post column derivatization for the determination of organic compounds: A review on instrumentation and chemistries. Analytica Chimica Acta. vol.798 p.1-24.
Zacharis Konstantinos, Kika Fotini S, Tzanavaras Paraskevas, Fytianos Konstantinos (2013). Development and validation of a rapid ultra high pressure liquid chromatographic method for the determination of methylxanthines in herbal infusions. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. vol.927 p.218-222.
Zacharis Konstantinos, Tzanavaras Paraskevas (2013). Preface : Trends and applications of fast liquid chromatography in bioanalysis. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. vol.927 p.1-2.
Zacharis Konstantinos, Tzanavaras Paraskevas, Vlessidis Athanasios G (2013). Determination of rimantadine in human urine by HPLC using a monolithic stationary phase and on-line post-column derivatization. Journal of Separation Science. vol.36 no.11 p.1720-1725.
Zacharis Konstantinos, Tzanavaras Paraskevas, Karakosta Theano D, Themelis Dimitrios (2013). Zwitterionic hydrophilic interaction chromatography coupled with post-column derivatization for the analysis of glutathione in wine samples. Analytica Chimica Acta. vol.795 p.75-81.

(2012)

Journal Article

Tzanavaras Paraskevas, Zacharis Konstantinos (2012). Editors’ preface for the special issue “Recent advances in separation science”. Central European Journal of Chemistry. vol.10 no.3 p.415-416.
Zacharis Konstantinos, Christophoridis Christophoros, Fytianos Konstantinos (2012). Vortex-assisted liquid–liquid microextraction combined with gas chromatography-mass spectrometry for the determination of organophosphate pesticides in environmental water samples and wines. Journal of Separation Science. vol.35 no.18 p.2422-2429.
Zacharis Konstantinos, Karakosta Theano D, Tzanavaras Paraskevas, Rigas Pantelis G, Themelis Dimitrios (2012). Chromatographic behavior of the biologically active proline derivativecaptopril on particulate, monolithic and core–shell narrow bore columns. Analytical Methods. vol.4 no.12 p.4373-4377.

Book Chapter

Zacharis Konstantinos, Tzanavaras Paraskevas (2012). Preservatives. Food Analysis by HPLC. Επιμέλεια:Leo M.L. Nollet, Fidel Toldra. Boca Raton, Fl. CRC Press. p.529-550.
Zacharis Konstantinos, Tzanavaras Paraskevas, Themelis Dimitrios (2012). Generic Preconcentration/Dilution Sequential Injection Manifold for the Automated Amperometric Determination of Free Cyanides from Sub-ppb to High ppm Levels (Chapter 15.). Portable Chemical Sensors : weapons against bioterrorism. Επιμέλεια:Dimitrios Nikolelis. Dordrecht, The Netherlands. Springer. p.279-286.

(2011)

Journal Article

Zacharis Konstantinos, Tzanavaras Paraskevas, Zotou Anastasia-Stella (2011). Ethyl propiolate as a post-column derivatization reagent for thiols: development of a green liquid chromatographic method for the determination of glutathione in vegetables. Analytica Chimica Acta. Vol.690 no.1 p.122-128.
Zacharis Konstantinos, Tzanavaras Paraskevas, Mouroutis P. N, Rigas Pantelis (2011). NBD-Cl as a Post-Column Reagent for Primary and Secondary Amines after Separation by Ion-Exchange Chromatography. Analalytical Letters. vol.44 no.10 p.1821-1834.
Zacharis Konstantinos, Tzanavaras Paraskevas (2011). HPLC separation of nimesulide and five impurities using a narrow-bore monolithic column: application to photo-degradation studies. Chromatographia. vol.73 no.3-4 p. 347–352.
Zacharis Konstantinos, Kika F. S, Tzanavaras Paraskevas, Rigas P, Kyranas E. R (2011). Development and validation of a rapid HPLC method for the determination of five banned fat-soluble colorants in spices using a narrow-bore monolithic column. Talanta. vol.84 no.2 p.480-486.

(2010)

Journal Article

Tzanavaras Paraskevas, Zacharis Konstantinos, Themelis Dimitrios (2010). Rapid determination of methylxanthines in real samples by high performance liquid chromatography using the new FastGradient® narrow bore monolithic column. Talanta. vol.81 no.4-5 p.1494-1501.
Tzanavaras Paraskevas, Zacharis Konstantinos, Themelis Dimitrios (2010). On-line derivatization of N-acetylcysteine using ethyl-propiolate as a novel advantageous reagent and sequential injection analysis. Analytical Letters. vol.43 no.12 p.1889-1901.
Zacharis Konstantinos, Tzanavaras Paraskevas, Roubos C, Dima K (2010). Solvent-based de-emulsification dispersive liquid-liquid microextraction combined with gas chromatography – mass spectrometry for determination of trace organochlorine pesticides in environmental water samples. Journal of Chromatography A. vol.1217 no.38 p.5896-5900.
Zacharis Konstantinos, Tzanavaras Paraskevas (2010). High throughput automated determination of glutathione based on the formation of a UV-absorbing thioacrylate derivative. Combinatorial Chemistry & High Throughput Screening. vol.13 no.6 p.461-468.

Book Chapter

Zacharis Konstantinos, Tzanavaras Paraskevas (2010). Preface. Reviews in Pharmaceutical and Biomedical Analysis. Επιμέλεια:Constantinos K. Zacharis and Paraskevas D. Tzanavaras. Bentham eBookss. p.ii-ii.

Book - Textbook

Zacharis Konstantinos (editor), Tzanavaras Paraskevas (editor) (2010). Reviews in Pharmaceutical and Biomedical Analysis. Bentham eBooks.

(2009)

Journal Article

Zacharis Konstantinos, Tzanavaras Paraskevas, Notou Maria, Zotou Anastasia-Stella, Themelis Dimitrios (2009). Separation and determination of nimesulide related substances for quality control purposes by micellar electrokinetic chromatography. Journal of Pharmaceutical and Biomedical Analysis. vol. 49 no. 2 p. 201-206.
Zacharis Konstantinos, Verdoukas A, Tzanavaras Paraskevas, Themelis Dimitrios (2009). Automated sample preparation coupled to sequential injection chromatography: on-line filtration and dilution protocols prior to separation. Journal of Pharmaceutical and Biomedical Analysis. vol.49 no.3 p.726-732.
Zacharis Konstantinos, Tzanavaras Paraskevas, Voulgaropoulos Anastasios, Karlberg B (2009). Amperometric determination of cyanides at the low ppb level by automated preconcentration based on gas diffusion coupled to sequential injection analysis. Talanta. vol.77 no. 5 p.1620-1626.
Zacharis Konstantinos, Tzanavaras Paraskevas, Themelis Dimitrios (2009). Ethyl-propiolate as a novel and promising analytical reagent for the derivatization of thiols: Study of the reaction under flow conditions. Journal of Pharmaceutical and Biomedical Analysis. vol.50 no.3 p.384-391.

Book Chapter

Zacharis Konstantinos, Tzanavaras Paraskevas, Themelis Dimitrios, Stratis Ioannis (2009). Sulphur dioxide in wines: Automated determination using flow injection analysis. Red wine and health. Επιμέλεια:O'Byrne, Paul. New York. Nova Science Publishers. p.303-322.

(2008)

Journal Article

Tzanavaras Paraskevas, Zacharis Konstantinos, Rigas Pantelis (2008). Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution. Journal of Pharmaceutical and Biomedical Analysis. vol.48 p.1254.
Tzanavaras Paraskevas, Zacharis Konstantinos (2008). Extraction of acyclovir from pharmaceutical creams prior to HPLC assay analysis: Optimization and validation of pretreatment protocols. Central European Journal of Chemistry. vol.6 no. 2 p.140-144.
Zacharis Konstantinos, Tzanavaras Paraskevas (2008). Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological material: A review of analytical methods. Journal of Pharmaceutical and Biomedical Analysis. vol.48 no. 3 p.483-496.

(2007)

Journal Article

Theodoridis Georgios, Zacharis Konstantinos, Voulgaropoulos Anastasios (2007). Automated sample treatment by flow techniques prior to liquid-phase separations. Journal of Biochemical & Biophysical Methods. vol.70 no.2 p.243-252.
Zacharis Konstantinos, Kalaitzantonakis Eftichios A, Podgornik Ales, Theodoridis Georgios (2007). Sequential injection affinity chromatography utilizing an albumin immobilized monolithic column to study drug–protein interactions. Journal of Chromatography A. vol.1144 no.1 p.126-134.

(2006)

Journal Article

Zacharis Konstantinos, Tempels F.W. Alexander, Theodoridis Georgios, Voulgaropoulos Anastasios, Underberg Willy J.M, Somsen Govert W, de Jong Gerhardus J (2006). Coupling of sequential injection analysis and capillary electrophoresis – Laser-induced fluorescence via a valve interface for on-line derivatization and analysis of amino acids and peptides. Journal of Chromatography A. vol.1132 no.1-2 p.297-303.
Zacharis Konstantinos, Theodoridis Georgios, Podgornik Ales, Voulgaropoulos Anastasios (2006). Incorporation of a monolithic column into sequential injection system for drug-protein binding studies. Journal of Chromatography A. vol.1121 no.1 p.46-54.
Zacharis Konstantinos, Theodoridis Georgios, Voulgaropoulos Anastasios (2006). Coupling of sequential injection with liquid chromatography for the automated derivatization and on-line determination of amino acids. Talanta. vol.69 no.4 p.841-847.

(2005)

Journal Article

Tzanavaras Paraskevas, Zacharis Konstantinos, Theodoridis Georgios, Kalaitzantonakis Eftichios A, Voulgaropoulos Anastasios (2005). Normal spectrophotometric and stopped-flow spectrofluorimetric sequential injection methods for the determination of alendronic acid, an anti-osteoporosis amino-bisphosphonate drug, in pharmaceuticals. Analytica Chimica Acta. vol.547 no.1 p.98-103.

(2004)

Journal Article

Theodoridis Georgios, Zacharis Konstantinos, Tzanavaras Paraskevas, Themelis Dimitrios, Economou Anastasios (2004). Automated sample preparation based on the sequential injection principle: Solid-phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography. Journal of Chromatography A. vol.1030 no.1-2 p.69-76.
Zacharis Konstantinos, Theodoridis Georgios, Voulgaropoulos Anastasios (2004). On-line coupling of sequential injection with liquid chromatography for the automated derivatization and determination of γ-aminobutyric acid in human biological fluids. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. vol.808 no.2 p.169-175.
Zacharis Konstantinos, Tzanavaras Paraskevas, Themelis Dimitrios, Theodoridis Georgios, Economou Anastasios, Rigas Pantekis G (2004). Rapid spectrofluorimetric determination of lisinopril in pharmaceutical tablets using sequential injection analysis. Analytical & Bioanalytical Chemistry. vol.379 p.759-763.

Journal Article

Manousi Natalia, Vlachaki Adamantia, Kika Fotini S, Markopoulou Aikaterini, Tzanavaras Paraskevas, Zacharis Konstantinos. Salting‐out homogeneous liquid‐liquid microextraction for the determination of azole drugs in human urine: Validation using total error concept. Journal of Separation Science. vol.45 no.6 p.1240-1251.
Synaridou Maria S, Monou Paraskevi Kyriaki, Zacharis Konstantinos, Fatouros Dimitrios, Panderi Irene, Markopoulou Aikaterini. Amoxicillin chewable tablets intended for pediatric use: formulation development, stability evaluation and taste assessment. Pharmaceutical Development and Technology. p.1-11.

Updated: 2023-09-13

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Quality Assurance Unit (MODIP)Aristotle University of Thessaloniki

You are here

Curriculum Vitae

Konstantinos Zacharis

Courses of Winter semester of 2023–24 academic year

Student Theses within AUTh

Undergraduate

Doctoral

Postgraduate

Postgraduate

Undergraduate

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Undergraduate

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Quality Assurance Unit (MODIP)
Aristotle University of Thessaloniki