Metabolic Engineering

Course Information
TitleΜεταβολική Μηχανική / Metabolic Engineering
SchoolChemical Engineering
Cycle / Level1st / Undergraduate
Teaching PeriodWinter
Course ID20002627

Programme of Study: PPS Tmīmatos CΗīmikṓn Mīchanikṓn (2021-sīmera)

Registered students: 0
OrientationAttendance TypeSemesterYearECTS
KORMOSElective CoursesWinter-5

Class Information
Academic Year2019 – 2020
Class PeriodWinter
Faculty Instructors
Weekly Hours3
Class ID
Course Type 2011-2015
Knowledge Deepening / Consolidation
Mode of Delivery
  • Face to face
Digital Course Content
The course is also offered to exchange programme students.
Language of Instruction
  • Greek (Instruction, Examination)
  • English (Instruction, Examination)
  • French (Instruction, Examination)
  • German (Instruction, Examination)
  • Italian (Instruction, Examination)
  • Spanish (Instruction, Examination)
Learning Outcomes
• Understanding basic concepts of cellular metabolism • Development of stoichiometric cellular response patterns • Understanding mass and energy balances in cells • Understanding the biological processes that determine the regulation of enzyme activity • Development of interdisciplinary thinking • Familiarity with Metabolic Path Analysis Software (Agilent GeneSpring)
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Work in teams
  • Advance free, creative and causative thinking
Course Content (Syllabus)
1. Introduction to metabolic engineering 2. Cellular metabolism 3. Cellular response models 4. Mass and energy balances in cells 5. Regulation of metabolic pathways 6. Examples of metabolic manipulation - metabolic engineering in practice 7. Synthesis of metabolic pathways 8. Metabolic flow analysis and applications 9. Metabolic Control Analysis 10. Structural analysis of metabolic networks 11. Dynamic analysis of metabolic network flows 12. Cell engineering and the overall function of metabolic networks
Metabolism, regulatory networks, metabolic flows, biotechnology, enzymes, cellular engineering
Educational Material Types
  • Notes
  • Slide presentations
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Laboratory Teaching
Course Organization
Written assigments15
Student Assessment
On the basis of the final report and the completion of a study project during the semester.
Student Assessment methods
  • Written Exam with Short Answer Questions (Formative)
  • Written Assignment (Formative)
Course Bibliography (Eudoxus)
Michael L. Shuler and Fikret Kargi, Μηχανική Βιοδιεργασιών - Bασικές Έννοιες, Πανεπιστημιακές Εκδόσεις ΕΜΠ 2005 Λυμπεράτος Γ. και Παύλου Σ. Εισαγωγή στη Βιοχημική Μηχανική, Εκδ. Τζιόλα, Θεσ/νίκη 2010
Additional bibliography for study
Gregory N. Stephanopoulos, Aristos Aristidou, Jens Nielsen, Metabolic engineering: Principles and Methodologies, Academic Press, 1998.
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