Aims of the course: To provide knowledge the higher organisms capacity that through the molecular and cellular elements of the immune system, develop mechanisms recognizing “self” from “non-self” components of the host-organism or the environment and exhibit natural innate or adaptive defense mechanisms leading in their neutralization or their selective tolerance. To familiarize students with the complex host defense mechanisms against external pathogens or infective environmental factors.
Skills: : By the end of this course, the students should be able to recognize the molecular and cellular components of immune system in association with knowledge using antibodies or antigens as basic tools in prevention-protection against pathogens, in diagnosis, in research as well as in the development of immunotechnology.
Course Content (Syllabus)
1. Basic principles, historical aspects and evolution.
2. Organization of immune system and lymphatic system.
3. Local immune system
4. Immune system cell populations
5. Host-defense mechanisms, Active (Vaccines) and passive (antisera) immunization.
6. Innate immunity
7. Adaptive Immunity
8. Structure and function of antibodies. Genetic and molecular basis of antibody variation.
11. Mechanisms of humoral immunity
12. Mechanisms of cellular immunity (molecular and cellular regulation-immunotolerance).
13. Major Histocompatibility complex and Transplantations.
14. Immunobiology of cancer – Autoimmunity.
15. Future and prospective.
1. Lymphoid organs
2. Cells of the lymphatic system
3. Lymphoid organ cell counting
4. Discrimination of viable and non-viable cells
5. Blood leucocyte isolation
6. Lymphocyte and macrophage separation
8.Serum Antibody detection (immunoprecipidation, immunodifusion, immunoelectrophoresis)
10. Hemolytic complement
immunobiology, antibodies, antigens, leucocytes,
Course Bibliography (Eudoxus)
1. Χατζηπέτρου-Κουρουνάκη Λ. (1987). Ανοσοβιολογία. Εκδόσεις University Studio Press. Θεσσαλονίκη.
2. Goldsby R., Th. Kindt, B. Osborne, J. Kuby (Ελληνική έκδοση). (2007). Ανοσολογία. Ιατρικές Εκδόσεις Π.Χ. Πασχαλίδης. Αθήνα.
3. Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai (Ελληνική έκδοση). (2019). Κυτταρική και Μοριακή Ανοσολογία. Εκδόσεις UTOPIA