Learning Outcomes
Upon successful completion of the course, students will be able to:
Understand the core regulatory mechanisms of carbohydrate, lipid, and protein metabolism.
Identify metabolic disorders related to dysregulation in these pathways and associate them with relevant diseases.
Explain the role of the endocrine system and hormone action in metabolic regulation.
Describe the pathways of iron and calcium metabolism, including cellular mechanisms of storage and response.
Analyze the integration and cross-regulation of metabolic pathways and the critical control points.
Understand the metabolic characteristics of major organs and tissues (e.g., brain, liver, muscle).
Evaluate the links between gluten, the gut microbiome, and disease processes, with a focus on biochemical and metabolic mechanisms.
Course Content (Syllabus)
Regulation of carbohydrate metabolism, metabolic disorders of carbohydrate pathways, and related diseases.
Regulation of lipid metabolism.
Coordination of lipid and carbohydrate metabolism – related abnormalities.
Regulation of protein metabolism, including targeted proteolysis of proteins.
Special topics in amino acid metabolism and its relation to metabolic diseases.
Hormonal regulation of metabolism: the endocrine system and hormones of the digestive tract.
Iron metabolism, transport, and storage in eukaryotic cells. Iron-sensing molecules and cellular response mechanisms to iron levels.
Calcium metabolism, metabolic pathways and cellular processes dependent on calcium.
Integration of metabolism, recurring strategies in metabolic regulation, major pathways and regulatory checkpoints.
Organ-specific metabolic profiles (brain, liver, muscle).
Gluten, gut microbiome, and associated diseases (digestive disorders, osteoarthritis, Alzheimer's, etc.).