TOXICOLOGY

Course Information
TitleΤΟΞΙΚΟΛΟΓΙΑ / TOXICOLOGY
Code71
FacultyHealth Sciences
SchoolPharmacy
Cycle / Level1st / Undergraduate
Teaching PeriodWinter
CommonNo
StatusActive
Course ID180000047
Class Information
Academic Year2025 – 2026
Class PeriodWinter
Faculty Instructors
Class ID
600280928
Course Type 2016-2020
  • Scientific Area
Course Type 2011-2015
Specific Foundation / Core
Mode of Delivery
  • Face to face
Digital Course Content
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
Upon successful completion of the course, students will have mastered basic concepts of Toxicology and Toxicokinetics, will have understood the molecular mechanisms leading to the appearance of toxic reactions in different systems and will have learnt the fundamental toxicity assays. Students will have been introduced to toxicity of various substances and the measures that need to be taken to counter them.
General Competences
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Work in teams
  • Advance free, creative and causative thinking
Course Content (Syllabus)
1) Theodoros Sklaviadis Introduction to Toxicology. Basic principles of the action of toxic substances. Toxicity testing in animals. Toxicokinetics: Absorption, distribution and excretion of toxic substances. Metabolism of toxic substances (xenobiotics). Mechanisms of nephrotoxicity and renal failure. Mechanisms of hepatotoxicity. Mechanisms of toxicity to the skin. Poisons and poisoning. Therapeutic management of poisoning - general and specific antidotes. Drug abuse of drugs and substances in sport (doping): Anabolics/Androgens, CNS stimulants, beta-blockers, diuretics, narcotics/analgesics, human growth hormone, erythropoietin and blood, ergogenic vitamins, non-pharmaceutical doping, control of doping. 2) Lefkothea Papadopoulou Mutagenesis – Τoxicogenomics – Νew technologies - Protocols for the detection of mutagenic substances – Carcinogenesis from environmental factors (chemicals, viruses, drugs, radiation) Teratogenesis 3) Konstantinos Xanthopoulos Mechanisms of toxicity in the nervous, hematopoietic, respiratory and cardiovascular systems Clinical Toxicology I: Toxicokinetics, treatment of acute poisoning, supportive measures, measures to reduce absorption of toxic substances, measures to increase excretion of toxic substances. Clinical Toxicology II: Paracetamol, salicylates, cardiac glycosides, ethanol, tricyclic antidepressants, benzodiazepines, derivatives phenothiazines, anticholinergics, amphetamine and related compounds, opioids, pesticides (chlorinated hydrocarbons, organophosphorus esters, carbamates), cyanide, iron, mercury.
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Laboratory Teaching
  • Use of ICT in Communication with Students
Description
Powerpoint presentations are used in the lectures. Whenever necessary multimedia files (videos and animations) are used to better illustrate concepts.
Course Organization
ActivitiesWorkloadECTSIndividualTeamworkErasmus
Lectures40✓
Reading Assigment80
Total120
Student Assessment
Description
Written exam at the end of the course. If necessary, exams can be taken remotely using online quizzes, through the elearning platform.
Student Assessment methods
  • Written Exam with Short Answer Questions (Summative)
  • Written Exam with Extended Answer Questions (Summative)
Bibliography
Course Bibliography (Eudoxus)
Βασική Τοξικολογία, Klaasen C., Watkins J. Κλινική Τοξικολογία και Θεραπευτική Αντιμετώπιση Δηλητηριάσεων, Νέου Π. Βασική και Κλινική Τοξικολογία, Τσιφτσόγλου Α. Τοξικολογία (επίτομο), Κουτσελίνης Α.
Additional bibliography for study
Επικαιροποίηση μέσω των διαλέξεων, ένα τμήμα των οποίων, ως αρχεία pdf, εμφανίζονται στην ιστοσελίδα: http://www.pharm.auth.gr/papadopoulou/lessonsgr.html καθώς και στη σελίδα του μαθήματος στο elearning: https://elearning.auth.gr/course/view.php?id=2414
Last Update
11-11-2020