Course Content (Syllabus)
Evidence- based dentistry. Research hypothesis and Study Design. Variables and Missing Data. Sampling, Randomization, Blinding
Experimental (Clinical trials) and Observational studies in dental research (CONSORT 2010 , STROBE 2007). An introduction to the IBM SPSS Statistics software. The Data and Variables View pages, the Output, the Syntax, using the Compute, Select, Recode and Weight functions. The R Commander (Fox).
Descriptive Statistics. An introduction to Probability. Random Variables and Distributions.
The Normal Distribution. Sampling Distributions. The Law of The Large Numbers and the Central Limit Theorem. Confidence Intervals, Hypothesis Testing, Type I and II errors, the Power of the Study. P-value, Statistical and Clinical Significance. How to read a paper.
Normality Tests and the Logarithmic Transformation. The t-test for One and Two Independent Samples and the Non- Parametric Mann Whitney U Test.
The t-test for Related Samples and the non-parametric Wilcoxon test. Review Exercises.
One-way Analysis of Variance. Welsh and Brown-Forsythe Robust Analysis of Variance. The Kruskal Wallis Non-Parametric ANOVA. Pair Wise Comparisons and the Bonferroni adjustment for the Type I Error.
Nominal Data, Cross-Sectional Studies. The Binomial Test, the Chi-Square Test, the Fisher’s Exact Test. Calculation of the p-value using the Monte Carlo Method..
Nominal Data on Related Groups. The McNemar Test, the Marginal Homogeneity Test (Stuart-Maxwell) and the Cochran’s Q Test. Review Exercises.
Statistical Analysis of Observational Studies (Cohort, Case-Control Studies). The Relative Risk (RR) and the Odds Ratios (OR). Screening tests.
Association, Agreement and Reliability. Pearson’s Correlation Coefficient, Spearman's Rank- Order Correlation Coefficient, Cohen's kappa, Intraclass Correlation Coefficient
Simple and Multiple Linear Regression. Logistic Regression
Statistical Analysis of Repeated Measurements and Longitudinal Studies. The Friedman test. Two-Way Analysis of Variance. An Introduction to the Mixed Linear Models.
Review – Exercises