Μικροβιολογία - Ανοσολογία Στόματος
| Title | Μικροβιολογία - Ανοσολογία Στόματος / Μικροβιολογία - Ανοσολογία Στόματος |
| Code | S201 |
| Faculty | Health Sciences |
| School | Dentistry |
| Cycle / Level | 2nd / Postgraduate |
| Teaching Period | Winter/Spring |
| Coordinator | Danai Apatzidou |
| Common | No |
| Status | Active |
| Course ID | 600020948 |
Programme of Study: PMS Periodontología kai Viología Emfyteumátōn (2024-sīmera)
Registered students: 4
| Orientation | Attendance Type | Semester | Year | ECTS |
|---|---|---|---|---|
| PERIODONTOLOGIA KAI VIOLOGIA EMFYTEUMATŌN | Compulsory Course | 2 | 1 | 2 |
| Academic Year | 2025 – 2026 |
| Class Period | Spring |
| Class ID | 600292946
|
Course Type 2021
Specific Foundation
Mode of Delivery
- Face to face
Digital Course Content
- e-Study Guide https://qa.auth.gr/en/class/1/600292946
- At the Website of the School: Υπό κατασκευή
Language of Instruction
- Greek (Instruction, Examination)
- English (Instruction, Examination)
Prerequisites
General Prerequisites
Ν/Α
Learning Outcomes
To acquire knowledge in microbiological aspects and host response implicated in the aetiopathogenesis of periodontal and peri-implant diseases.
General Competences
- Apply knowledge in practice
- Retrieve, analyse and synthesise data and information, with the use of necessary technologies
- Adapt to new situations
- Be critical and self-critical
- Advance free, creative and causative thinking
Course Content (Syllabus)
General principles of immunity-Innate and Acquired immunity
Microflora in health and disease of periodontal disease
Microflora in health and disease of periimplant disease
Smoking and tissue changes-Role in microflora and immune response by the periodontal patient
Pathogenic role of bacteria-Special bacteria
Ecosystem-Oral environment
Acquired film – dental plaque, evolution, development
Root decay-periodontal inflammation-Similarities and disimilarities
Epigenetics and its role in pathogenesis of periodontal disease
Aging of the immune response of the host. Age as a factor in pathogenesis of periodontal disease
Interactions between host and microbial factor in pathogenesis of periodontal and periimplant diseases. Part I and Part II
Fungal-bacterial dysbiosis in the oral mucosa, role in mucosal inflammation and barrier breach
Exams
Keywords
Oral Immunology, Oral microbiology, Pathogenesis, Periodontal Diseases
Educational Material Types
- Notes
- Slide presentations
- Book
Use of Information and Communication Technologies
Use of ICT
- Use of ICT in Course Teaching
- Use of ICT in Laboratory Teaching
- Use of ICT in Communication with Students
Description
As above
Course Organization
| Activities | Workload | ECTS | Individual | Teamwork | Erasmus |
|---|---|---|---|---|---|
| Lectures | 26 | ||||
| Seminars | 26 | ||||
| Tutorial | 0 | ||||
| Total | 52 |
Student Assessment
Description
Performance during the seminars and at the final exam
Student Assessment methods
- Written Exam with Multiple Choice Questions (Summative)
- Written Exam with Short Answer Questions (Summative)
- Written Exam with Extended Answer Questions (Summative)
- Written Assignment (Summative)
Bibliography
Additional bibliography for study
Μicroflora in periodontal health and disease
1. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999 May 21;284(5418):1318-22. doi: 10.1126/science.284.5418.1318. PMID: 10334980.
2. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000. 1994 Jun;5:7-25. doi: 10.1111/j.1600-0757.1994.tb00016.x. PMID: 9673160.
3. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994 Jun;5:78-111. doi: 10.1111/j.1600-0757.1994.tb00020.x. PMID: 9673164.
4. Socransky SS, Haffajee AD. Microbial mechanisms in the pathogenesis of destructive periodontal diseases: a critical assessment. J Periodontal Res. 1991 May;26(3 Pt 2):195-212. doi: 10.1111/j.1600-0765.1991.tb01646.x. PMID: 1831843.
5. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000. 2002;28:12-55. doi: 10.1034/j.1600-0757.2002.280102.x. PMID: 12013340.
Oral ecosystem
1. Samaranayake L, Matsubara VH. Normal Oral Flora and the Oral Ecosystem. Dent Clin North Am. 2017 Apr;61(2):199-215. doi: 10.1016/j.cden.2016.11.002. PMID: 28317562.
Smear layer
1. Scherman L. Le point sur la "smear layer" en 1990 [Focus on the smear layer in 1990]. Rev Odontostomatol (Paris). 1991 Mar-Apr;20(2):109-19. French. PMID: 1947585.
2. Pashley DH. Smear layer: overview of structure and function. Proc Finn Dent Soc. 1992;88 Suppl 1:215-24. PMID: 1508877.
Epigenetics and periodontal pathology
1. Larsson L, Thorbert-Mros S, Lopez-Lago A, Kalm J, Shikhan A, Berglundh T. Expression of TET2 enzyme indicates enhanced epigenetic modification of cells in periodontitis. Eur J Oral Sci. 2016 Aug;124(4):329-33. doi: 10.1111/eos.12281. Epub 2016 Jun 14. PMID: 27297088.
2. Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila YL, Fenno JC. Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection. Arch Oral Biol. 2014 Oct;59(10):1056-64. doi: 10.1016/j.archoralbio.2014.06.003. Epub 2014 Jun 14. PMID: 24973519; PMCID: PMC4120104.
3. Takai R, Uehara O, Harada F, Utsunomiya M, Chujo T, Yoshida K, Sato J, Nishimura M, Chiba I, Abiko Y. DNA hypermethylation of extracellular matrix-related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis. J Periodontal Res. 2016 Aug;51(4):508-17. doi: 10.1111/jre.12330. Epub 2015 Nov 9. PMID: 26548368.
4. Uehara O, Abiko Y, Saitoh M, Miyakawa H, Nakazawa F. Lipopolysaccharide extracted from Porphyromonas gingivalis induces DNA hypermethylation of runt-related transcription factor 2 in human periodontal fibroblasts. J Microbiol Immunol Infect. 2014 Jun;47(3):176-81. doi: 10.1016/j.jmii.2012.08.005. Epub 2012 Sep 24. PMID: 23010540.
The effect of aging on host defense mechanisms: age as related to pathogenicity
1. Szarc vel Szic K, Declerck K, Vidaković M, Vanden Berghe W. From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics. 2015 Mar 25;7(1):33. doi: 10.1186/s13148-015-0068-2. PMID: 25861393; PMCID: PMC4389409.
2. Kilian M, Chapple IL, Hannig M, Marsh PD, Meuric V, Pedersen AM, Tonetti MS, Wade WG, Zaura E. The oral microbiome - an update for oral healthcare professionals. Br Dent J. 2016 Nov 18;221(10):657-666. doi: 10.1038/sj.bdj.2016.865. PMID: 27857087.
3. Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, Witkowski JM, Franceschi C. Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Front Immunol. 2018 Jan 10;8:1960. doi: 10.3389/fimmu.2017.01960. PMID: 29375577; PMCID: PMC5767595.
4. Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018 Oct;14(10):576-590. doi: 10.1038/s41574-018-0059-4. PMID: 30046148.
5. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039. PMID: 25417146; PMCID: PMC4852871.
Host – microbial interactions on the pathogenesis of periodontal and peri-implant tissues
1. Bostanci N, Belibasakis GN. Gingival crevicular fluid and its immune mediators in the proteomic era. Periodontol 2000. 2018 Feb;76(1):68-84. doi: 10.1111/prd.12154. Epub 2017 Nov 30. PMID: 29193353.
2. Hajishengallis G, Korostoff JM. Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later. Periodontol 2000. 2017 Oct;75(1):116-151. doi: 10.1111/prd.12181. PMID: 28758305; PMCID: PMC5539911.
3. Bostanci N, Belibasakis GN. Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiol Lett. 2012 Aug;333(1):1-9. doi: 10.1111/j.1574-6968.2012.02579.x. Epub 2012 May 28. PMID: 22530835.
Fungal-bacterial dysbiosis in the oral mucosa, role in mucosal inflammation and barrier breach
1. Xu H, Dongari-Bagtzoglou A. Shaping the oral mycobiota: interactions of opportunistic fungi with oral bacteria and the host. Curr Opin Microbiol. 2015 Aug;26:65-70. doi: 10.1016/j.mib.2015.06.002. Epub 2015 Jun 19. PMID: 26100661; PMCID: PMC4577367.
2. Ranjan A, Dongari-Bagtzoglou A. Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments. J Fungi (Basel). 2018 Sep 18;4(3):112. doi: 10.3390/jof4030112. PMID: 30231476; PMCID: PMC6162738.
Last Update
10-01-2024
