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Aristotle University of Thessaloniki
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Dionysia Papagiannopoulou
Associate Professor, School of Pharmacy
Personal Information
2310998680
papagd@pharm.auth.gr
Scopus ID
6506862166
https://orcid.org/0000-0002-7833-8744
Γνωστικό Αντικείμενο
:
Φαρμακευτική Χημεία με έμφαση στη Ραδιοφαρμακευτική Χημεία
Επιστημονική Ειδίκευση
:
Χημεία
Ιατρική διαγνωστική και τεχνολογία θεραπείας
Φαρμακευτική
Education
Προπτυχιακές Σπουδές
1997
Πτυχίο
Χημείας
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Greece
Διδακτορικό Δίπλωμα
2001
Διδακτορικό Δίπλωμα
Χημείας
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Greece
Ραδιοφαρμακευτική Χημεία/Ανόργανη Χημεία
Course Work
Courses of Winter semester of 2025–26 academic year
SCHOOL OF PHARMACY
48
ORGANIC PHARMACEUTICAL CHEMISTRY I
75
ORGANIC PHARMACEUTICAL CHEMISTRY
81
RADIOPHARMACEUTICAL CHEMISTRY
ΝΠ18-00
Research Project
ΝΠ18-04
Pharmaceutical Chemistry of Elements and of the Inorganic Compounds
ΝΠ18-Δ1
Diploma Thesis 1/2
ΝΠ18-Δ2
Diploma Thesis 2/2
ΝΠ18-Π1
Practical Training I
ΠΑ-1
Practical Training I
ΠΡ
PRACTICE
POSTGRADUATE STUDIES PROGRAMME OF THE SCHOOL OF PHARMACY "INDUSTRIAL PHARMACY"
ΠΜΣΒΦ-001
Design, development and pharmacological evaluation of active drug molecules – Preformulation studies
ΠΜΣΒΦ-004
1st stage of elaboration of diploma thesis
ΠΜΣΒΦ-008
2nd stage of elaboration of diploma thesis
ΠΜΣΒΦ-Μ1
Design, development and pharmacological evaluation of active drug molecules – Preformulation studies
JOINT POSTGRADUATE PROGRAMME PHARMACEUTICAL LAW: LEGISLATION AND PRACTICE
ΦΔΑ4
VETERINARY, AGRICULTURAL AND BIOTECHNOLOGICAL DRUGS, RADIO-PHARMACEUTICALS AND MEDICINAL PRODUCTS
Farmakochīmikī kai Farmakologikī Anáptyxī Farmakomoríōn
ΦΦΑΦ-01
Rational Drug Design
ΦΦΑΦ-02
Molecular Pharmacology
ΦΦΑΦ-03
Pharmaceutical Biotechnology-Biopharmaceuticals
ΦΦΑΦ-06
Master's Diploma Thesis IΙ
Courses of Spring semester of 2025–26 academic year
SCHOOL OF PHARMACY
34
PHARMACEUTICAL CHEMISTRY (ORGANOMETALLICS AND HORMONES)
81
RADIOPHARMACEUTICAL CHEMISTRY
ΔΕ1
DIPLOMA THESIS 1/2
ΔΕ2
DIPLOMA THESIS 2/2
ΝΠ18-00
Research Project
ΝΠ18-04
Pharmaceutical Chemistry of Elements and of the Inorganic Compounds
ΝΠ18-31
Gen. Pharmaceutical Chemistry
ΝΠ18-50
Pharmaceutical Chemistry IV
ΝΠ18-Δ1
Diploma Thesis 1/2
ΝΠ18-Δ2
Diploma Thesis 2/2
ΝΠ18-Π2
Practical Training II
ΝΠ38
ORGANIC-RADIOPHARMACEUTICAL CHEMISTRY
ΠΑ-2
Practical Training II
ΠΡ
PRACTICE
SCHOOL OF CHEMISTRY
ΕΦ935
Pharmaceutical Chemistry
Κ312
Pharmaceutical Chemistry
POSTGRADUATE STUDIES PROGRAMME "PRECISION MEDICINE - TRANSLATION RESEARCH AND THERAPEUTICS"
ΙΑΒ01
Innovative Therapies and regulatory framework
Farmakochīmikī kai Farmakologikī Anáptyxī Farmakomoríōn
ΦΦΑΦ-04
ΦΦΑΦ-05
Master's Diploma Thesis I
Theses Supervised
Student Theses within AUTh
In progress
Postgraduate
No title
Synthesis of cinnamic acid amides for the development of hybrid compounds for neurodegenerative diseases
Undergraduate
Development and biological evaluation of new radiodiagnostic mixed-ligand technetium-99m compounds
Doctoral
Design and synthesis of new-multitarget compaunds for the diagnosis and treatment of neurodegenerative diseases
2025–2026
Undergraduate
Development of modified antibacterial agents for the diagnosis of infection
Development of therapeutic and radiodiagnostic derivatives of fluoroquinolones
Development of cefalosporin derivatives for the diagnosis of infection
Synthesis, characterization and evaluation of bifunctional bioactive molecules
2024–2025
Undergraduate
Development of new metal chelates for therapy and diagnosis
Development of new derivative of new derivative of cytoxic fluoroquinolone
Preparation of new derivative of fluoroquinolone as diagnostic and cytotoxic agents
Desingn and synthesis of conjugated metal chelates for therapy and diagnosis
2022–2023
Postgraduate
Development of theranostic agents of the anthraquinone scaffold with the application of the radiodiagnostic technetium-99m
Development of diagnostic radiotracers of technetium-99m with an anthraquinone derivative and in-vitro and in-vivo biological evaluation studies
Undergraduate
Synthesis and evaluation of texhnetium-99m radiolabeled fluoroquinolone
Synthesis and evaluation of new rhenium compounds for thw development of artificial radiodiagnostic compounds -99m
Synthesis and evaluation of anthraquinone derivatives for the development of novel radiodiagnostic compounds
2021–2022
Doctoral
No title
2020–2021
Postgraduate
No title
No title
Undergraduate
Design, synthesis and characterization of rhenium tricarbonyl complex with modified ciprofloxacin derivative for the development of radiodiagnostic compounds of technetium-99m
2019–2020
Undergraduate
SYNTHESIS AND CHARACTERIZATION OF THE Tc AND Re COMPLETES WITH CIPROFLOXACIN
No title
2018–2019
Undergraduate
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF RHENIUM AND 99m-TECHNETIUM COMPLEXES WITH FLAVONOIDS
Synthesis, characterization and evaluation of antioxidant properties of rhenium tricaronyl complexes with 3,7,4’- trihydroxyflavone and 3-hydroxyflavone
2017–2018
Undergraduate
1) SYNTHESIS AND CHARACTERIZATION OF RHENIUM AND TECHNETIUM QUINOLONE COMPLEXES 2) QUALITY CONTROL OF TECHNETUM RADIOFARMACEUTICALS IN COOPERATION WITH HOSPITAL AHEPA.
Metallation of Flavonoids with Rhenium and Technetium
2015–2016
Undergraduate
No title
2014–2015
Doctoral
No title
2012–2013
Undergraduate
DESIGN, SYNTHESIS AND EVALUATION OF TECHNETIUM COMPLEXES OF THE fac-[99mTc(CO)3(NSN)]+ TYPE AS POTENTIAL MYOCARDIAL IMAGING AGENTS
2010–2011
Postgraduate
No title
Administrative Work
Τμήματος
#
Από
Έως
Θέση Όργανο / Επιτροπή
1
2011
2012
Member, Επιτροπή Syllabus
2
2011
2012
Member, Επιτροπη Ιστοσελίδας Τμήματος
Ιδρύματος
#
Από
Έως
Θέση Όργανο / Επιτροπή
1
2011
2015
Member, Συμβουλιο Περιβαλλοντος
Research Projects
Coordinator
2025–2029
Post Graduate Program: "Pharmacochemical and Pharmacological Development of Drug Molecules"
2024–2031
Scientific editing of translation of Medicinal Chemistry textbook
2020–2021
Scientific editing of translation of Medicinal Chemistry textbook
Participant
2025–2027
Internship Office of AUTH
2021–2026
“Pharmaceutical Law: Legislation and Practice”
2020–2026
Precision Medicine-Translational Research and therapeutics
2019–2020
2018–2022
Internship of Aristotle University of Thessaloniki
2018–2026
2017–2018
Internship of Aristotle University of Thessaloniki
2016–2017
Internship of Aristotle University of Thessaloniki. Subproject 2 - Central Actions for the Internship of Aristotle University of Thessaloniki
2014–2025
2003–2008
Reconstuction of Undergraduate Studies Programme of the Pharmaceutical Dept. of Auth
2002–2008
Pharmaceutical Science
1997–2023
Πληρωμή μελών ΔΕΠ ΑΠΘ για αξιολογήσεις και λοιπές υπηρεσίες - Ν. 2530/97 (ΓΓΕΤ )
Non ELKE AUTh
Participation
2012-2016
Λειτουργικά μεταλλικά σύμπλοκα που συνδέονται με βιομόρια
Publications
(2024)
Journal Article
Paparidis Georgios
,
Akrivou Melpomeni
,
Psomas Georgios
,
Vizirianakis Ioannis
,
Hatzidimitriou Antonios
,
Gabriel Catherine
,
Sarigiannis Dimosthenis
,
Papagiannopoulou Dionysia
.
(2024)
.
Novel Tricarbonylrhenium-Anthrapyrazole Complexes with DNA-Binding and Antitumor Properties: In Vitro and In Vivo Pharmacokinetic Studies with 99mTc-Analogue
.
Inorganics
.
vol.12 no.9 p.254 (22 pages)
(2023)
Journal Article
Glykofridi Pigi
,
Tziouri Vassiliki-Eleni
,
Xanthopoulos Konstantinos
,
Vlachou Maria-Eirini
,
Correia Susana
,
Fischer Anna-Lisa
,
Thuene Katrin
,
Hatzidimitriou Antonios
,
Zerr Inga
,
Schmitz Matthias
,
Sklaviadis Theodoros
,
Hadjipavlou-Litina Dimitra
,
Papagiannopoulou Dionysia
.
(2023)
.
Synthesis, structural characterization and study of antioxidant and anti-PrPSc properties of flavonoids and their rhenium(I)–tricarbonyl complexes
.
Journal of Biological Inorganic Chemistry
.
vol.28 no.2 p.235–247
(2021)
Journal Article
Miliotou Androulla N.
,
Papagiannopoulou Dionysia
,
Vlachaki Efthymia
,
Samiotaki Martina
,
Laspa Dimitra
,
Theodoridou Stamatia
,
Tsiftsoglou Asterios
,
Papadopoulou Lefkothea
.
(2021)
.
PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients’ RBCs ex vivo in the frame of Protein Replacement Therapy
.
Journal of Biological Research-Thessaloniki
.
vol.28 no.1
(2020)
Journal Article
Kaiafas Georgios C.
,
Papagiannopoulou Dionysia
,
Miliotou Αndroulla N.
,
Tsingotjidou Anastasia
,
Chalkidou Parthenopi C.
,
Tsika Aikaterini C.
,
Spyroulias Georgios A.
,
Tsiftsoglou Asterios
,
Papadopoulou Lefkothea
.
(2020)
.
In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations
.
Molecular Genetics and Metabolism Reports
.
vol.25 no.C p.100683
Kyriazopoulos Achilleas
,
Alexiou Aikaterini-Lamprini
,
Miliotou Androulla
,
Papadopoulou Lefkothea
,
Hatzidimitriou Antonios
,
Papagiannopoulou Dionysia
.
(2020)
.
Effect of the triphenylphosphonium cation on the biological properties of new rhenium and technetium-99m fac-[M(CO)3(NSN)]±-type complexes: Synthesis, structural characterization, in vitro and in vivo studies
.
Inorganica Chimica Acta
.
vol.511 p.Article number: 119807 (7 pages)
(2019)
Journal Article
Pagoni H.
,
Xylouri V.
,
Kaiafas G.C
,
Lazou Marialena
,
Bombola G.
,
Tsoukas E.
,
Papadopoulou Lefkothea
,
Psomas Georgios
,
Papagiannopoulou Dionysia
.
(2019)
.
Organometallic rhenium tricarbonyl enrofloxacin and levofloxacin complexes: Synthesis, albumin binding, DNA interaction and cell viability studies
.
Journal of Biological Inorganic Chemistry
.
vol.24 no.5 p.609–619
(2018)
Journal Article
Maskovic Jelena M.
,
Hatzidimitriou Antonios
,
Damjanovic Ana
,
Stanojkovic Tatjana P.
,
Trifunovic Srecko R.
,
Geronikaki Athina
,
Papagiannopoulou Dionysia
.
(2018)
.
Synthesis, characterization and biological evaluation of Pd(II), Cu(II), Re(I) and Tc-99m(I) thiazole-based complexes
.
MedChemComm
.
vol.9 no.5 p.831-842
Book Chapter
Papagiannopoulou Dionysia
,
Hadjipavlou-Litina Dimitra
.
(2018)
.
Computational modeling of diagnostic imaging agents for alzheimer’s disease: molecular imaging agents for the in vivo detection of amyloid plaques in Alzheimer’s disease
.
Neuromethods
.
New York
.
Humana Press, New York, NY
.
τομ.132 p.463-479
(2016)
Journal Article
Kydonaki T.
,
Tsoukas E.
,
Mendes F.
,
Chatzidimitriou Antonios
,
Paulo A
,
Papadopoulou Lefkothea
,
Papagiannopoulou Dionysia
,
Psomas Georgios
.
(2016)
.
Synthesis, characterization and biological evaluation of 99mTc/Re–tricarbonyl quinolone complexes
.
Journal of Inorganic Biochemistry
.
vol.160 p.94-105
(2015)
Journal Article
Karavassili C.
,
Spanakis M.
,
Papagiannopoulou Dionysia
,
Vizirianakis Ioannis
,
Fatouros Dimitrios
,
Koutsopoulos S.
.
(2015)
.
Bioactive Self-Assembling Lipid-Like Peptides as Permeation Enhancers for Oral Drug Delivery
.
Journal of Pharmaceutical Sciences
.
vol.104 no.7 p.2304-2311
Papagiannopoulou Dionysia
,
Vardouli L.
,
Dimitriadis F.
,
Apostolidis Apostolos
.
(2015)
.
Retrograde transport of radiolabelled botulinum neurotoxin type a (bont/a) to the central nervous system following intradetrusor injection in rats
.
British Journal of Urology
(2014)
Journal Article
Papagiannopoulou Dionysia
,
Triantis C.
,
Vassileiadis V.
,
Raptopoulou C.
,
Psycharis V.
,
Terzis A.
,
Pirmettis I.
,
Papadopoulos M.
.
(2014)
.
Synthesis, structural characterization and radiochemistry of di- and tricarbonyl Re(I) and 99mTc(I) complexes with 8-hydroxyquinoline or 8-mercaptoquinoline and triphenylphosphine
.
Polyhedron
.
vol.68 p.46-52
Vassileiadis V.
,
Triantis C.
,
Raptopoulou C.
,
Psycharis V.
,
Terzis A.
,
Pirmettis I.
,
Papadopoulos M.
,
Papagiannopoulou Dionysia
.
(2014)
.
Synthesis, structural characterization and radiochemistry of ‘‘2 + 1’’ fac-[99mTc/Re(CO)3(L)(2-mercaptopyridine)] complexes, where L is phosphine or isocyanide
.
Polyhedron
.
vol.81 p.511-516
(2012)
Journal Article
Makris G.
,
Karagiorgou O.
,
Papagiannopoulou Dionysia
,
Panagiotopoulou A.
,
Raptopoulou C.
,
Terzis A.
,
Psycharis V.
,
Pelecanou M.
,
Pirmettis I.
,
Papadopoulos M.
.
(2012)
.
Rhenium(I) and technetium(I) tricarbonyl complexes with [NSO]-type chelators: Synthesis, structural characterization, and radiochemistry
.
European Journal of Inorganic Chemistry
.
Vol. 2012 no. 19 p.3132-3139
Papagiannopoulou Dionysia
.
(2012)
.
Radiopharmaceutical applications of organometallic technetium and rhenium complexes
.
Current Inorganic Chemistry
.
vol.2 no. 2 p. 228-247
(2011)
Journal Article
Kyprianidou P.
,
Tsoukalas C.
,
Chiotellis A.
,
Papagiannopoulou Dionysia
,
Raptopoulou C. P.
,
Terzis A.
,
Pelecanou M.
,
Papadopoulos M.
,
Pirmettis I.
.
(2011)
.
First example of well-characterized Re and 99mTc tricarbonyl complexes of ciprofloxacin and norfloxacin in the development of infection-specific imaging agents
.
Inorganica Chimica Acta
.
vol.370 no.1 p.236-242
Papagiannopoulou Dionysia
,
Tsoukalas C.
,
Makris G.
,
Raptopoulou C. P.
,
Psycharis V.
,
Leondiadis L.
,
Gdniazdowska E.
,
Koźmiński P.
,
Fuks L.
,
Pelecanou M.
,
Pirmettis I.
,
Papadopoulos M. S.
.
(2011)
.
Histidine derivatives as tridentate chelators for the fac-[M I(CO) 3] (Re, 99mTc, 188Re) core: Synthesis, structural characterization, radiochemistry and stability
.
Inorganica Chimica Acta
.
vol.378 no.1 p.333-337
Tsotakos T.
,
Tsoukalas C.
,
Patsis G.
,
Panagiotopoulou A.
,
Nikolić N.
,
Jankovic D.
,
Djokić D.
,
Raptopoulou C. P.
,
Terzis A.
,
Papagiannopoulou Dionysia
,
Pelecanou M.
,
Papadopoulos M.
,
Pirmettis I.
.
(2011)
.
Benzimidazole derivatives as NSO ligands for the fac-[M(CO) 3] + (M = Re, 99mTc)
.
Inorganica Chimica Acta
.
vol.377 no.1 p.62-68
(2010)
Journal Article
Papagiannopoulou Dionysia
,
Makris G.
,
Tsoukalas C.
,
Raptopoulou C. P.
,
Terzis A.
,
Pelecanou M.
,
Pirmettis I.
,
Papadopoulos M. S.
.
(2010)
.
Rhenium(I) and technetium(I) fac-M(NSO) (CO) 3 (M = Re 99mTc) tricarbonyl complexes, with a tridentate NSO bifunctional agent: Synthesis structural characterization, and radiochemistry
.
Polyhedron
.
vol.29 no.2 p.876-880
(2009)
Journal Article
Karagiorgou O.
,
Papagiannopoulou Dionysia
,
Kyprianidou P.
,
Patsis G.
,
Panagiotopoulou A.
,
Tsoukalas C.
,
Raptopoulou C. P.
,
Pelecanou M.
,
Pirmettis I.
,
Papadopoulos M.
.
(2009)
.
Synthesis and structural characterization of novel neutral fac-M(CO)3(NSO) complexes (M=Re,99mTc) with N-acetylcysteine derivatives as tridentate NSO ligands.
.
Polyhedron
.
vol.28 no.15 p.3317-3321
Kyprianidou P.
,
Tsoukalas C.
,
Patsis G.
,
Papagiannopoulou Dionysia
,
Nikolic N.
,
Jankovic D.
,
Djokic D.
,
Raptopoulou C. P.
,
Pelecanou M.
,
Papadopoulos M.
,
Pirmettis I.
.
(2009)
.
Rhenium(I) and technetium-99m(I) fac-tricarbonyl complexes with 4-(imidazolin-2-yl) -3-thiabutanoic acid derivatives as tridentate ligands: Synthesis and structural characterization.
.
Polyhedron
.
vol.28 no.15 p.3171-3176
(2007)
Journal Article
Papagiannopoulou D.
,
Pirmettis I.
,
Pelecanou M.
,
Komiotis D.
,
Raptopoulou C. P.
,
Terzis A.
,
Papadopoulos M. S.
.
(2007)
.
Synthesis and structural characterization of neutral “3+2” οxorhenium and οxotechnetium complexes of the 2-mercaptoethyl-N-glycine (SNO) / 2, 2΄-bipyridine (NN) mixed ligand system.
.
Inorg.Chim.Acta
.
vol.360 no.11 p.3597-3602
(2005)
Journal Article
Terry J.
,
Grzenia B.
,
Papagiannopoulou Dionysia
,
Kyger J.
,
Jurisson S.
,
Robertson J. D.
.
(2005)
.
Structural determination of 99mTc radiopharmaceuticals and compounds using X-ray absorption spectroscopy.
.
Journal of Radioanalytical and Nuclear Chemistry
.
vol.263 no.2 p.531-537
(2003)
Journal Article
Kurti L.
,
Papagiannopoulou Dionysia
,
Papadopoulos M.
,
Pirmettis I.
,
Raptopoulou C.
,
Terzis A.
,
Chiotellis Efstratios
,
Harmata M.
,
Kuntz R.
,
Pandurangi R.
.
(2003)
.
Synthesis and Characterization of Novel 99gTc(V) and Re(V) Complexes with Water-Soluble Tetraaza Diamido Dipyridino Ligands: Single-Crystal X-ray Structural Investigations of Mono- and Dinuclear Complexes
.
Inorganic Chemistry
.
vol.42 no. 9 p.2960-2967
Papachristou M.
,
Pirmettis I.
,
Tsoukalas C.
,
Papagiannopoulou Dionysia
,
Raptopoulou C.
,
Terzis A.
,
Stassinopoulou C.
,
Chiotellis Efstratios
,
Pelecanou M.
,
Papadopoulos M.
.
(2003)
.
Synthesis and Characterization of Novel Oxotechnetium (99Tc and 99mTc) and Oxorhenium Complexes from the 2,2’-Bipyridine (NN)/Thiol(S) Mixed-Ligand System
.
Inorganic Chemistry
.
vol.42 no. 18 p.5778-5784
(2002)
Journal Article
Papagiannopoulou Dionysia
,
Pirmettis I.
,
Pelecanou M.
,
Tsoukalas C.
,
Raptopoulou C.
,
Terzis A.
,
Chiotellis Efstratios
,
Papadopoulos M.
.
(2002)
.
Synthesis and Structural characterization of a novel Re[P][NN][S][SO] mixed ligand Rhenium(III) complex
.
Inorganica Chimica Acta
.
vol.346 p.270-274
Papagiannopoulou Dionysia
,
Pirmettis I.
,
Tsoukalas C.
,
Nikoladou L.
,
Drossopoulou G.
,
Dalla M.
,
Pelecanou M.
,
Papadopoulou-Daifotis Z.
,
Papadopoulos M.
,
Chiotellis Efstratios
.
(2002)
.
Oxotechnetium 99mTcO[SN(R)S][S] complexes as potential 5-HT1A receptor imaging agents
.
Nuclear Medicine & Biology
.
vol.29 no. 8 p.825-832
(2001)
Journal Article
Bouziotis P.
,
Papagiannopoulou Dionysia
,
Pirmettis I.
,
Pelecanou M.
,
Raptopoulou C.
,
Stassinopoulou C.
,
Terzis A.
,
Friebe M.
,
Spies H.
,
Chiotellis Efstratios
.
(2001)
.
Synthesis and structural characterization of two cis-dioxorhenium(V) ReO2[SN][P] mixed-ligand complexes
.
Inorganica Chimica Acta
.
vol.320 no.1-2 p.174-177
Papagiannopoulou Dionysia
,
Pirmettis I.
,
Maina T.
,
Pelecanou M.
,
Nikolopoulou A.
,
Chiotellis Elias
,
Raptopoulou C.
,
Vlahos A.
,
Terzis A.
,
Papadopoulos M.
,
Chiotellis Efstratios
.
(2001)
.
Development of novel mixed-ligand oxotechnetium [SNS/S] complexes as potential 5-HT1A receptor imaging agents
.
Journal of Biological Inorganic Chemistry
.
vol.6 p.256-265
Journal Article
Kaifas G.
,
Papagiannopoulou Dionysia
,
Miliotou A.
,
Tsingotjidou Anastasia
,
Chalkidou P.C.
,
Tsika A.C.
,
Spyroulias G.A.
,
Tsiftsoglou Asterios
,
Papadopoulou Lefkothea
.
In vivo Biodistribution study of TAT-L-Sco2 Fusion Protein, Developed as Protein Therapeutic for Mitochondrial Disorders attributed to SCO2 Mutations
.
Molecular Genetics and Metabolism Reports
Updated: 2026-05-21