Course Information
TitleΒιοτεχνολογία / Biotechnology
SchoolChemical Engineering
Cycle / Level1st / Undergraduate
Teaching PeriodWinter
Course ID20002619

Programme of Study: PPS Tmīmatos CΗīmikṓn Mīchanikṓn (2021-sīmera)

Registered students: 0
OrientationAttendance TypeSemesterYearECTS
KORMOSCompulsory Course535

Class Information
Academic Year2019 – 2020
Class PeriodWinter
Faculty Instructors
Weekly Hours4
Class ID
Course Type 2016-2020
  • Background
Course Type 2011-2015
General Foundation
Mode of Delivery
  • Face to face
The course is also offered to exchange programme students.
Language of Instruction
  • Greek (Instruction, Examination)
  • English (Instruction, Examination)
General Prerequisites
There are no prerequisites for a student to register for the specific class
Learning Outcomes
As part of this course, students will: • receive training that leads to a full understanding of the principles and practices of biotechnology in modern biochemical, biological, and biomedical engineering • be trained and informed on current scientific literature, computational approaches and online information related to biotechnology and their connection with modern chemical engineering • acquire a broad training base on technical skills in biotechnology methods that involve interdisciplinary contributions from chemistry, molecular biology and chemical engineering (reactors, mass balance, mass and heat transfer, etc.) • enhance critical thinking, their ability to think through and solve problems in the field of biotechnology involving microorganisms, genetic engineering, molecular biology, enzymes, biodegradations, small and large-scale biochemical processes • will be able to communicate effectively with biotechnology and other interdisciplinary professionals in (bio)chemical engineering and related industry
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Adapt to new situations
  • Make decisions
  • Work autonomously
  • Work in an interdisciplinary team
  • Generate new research ideas
  • Design and manage projects
  • Respect natural environment
  • Advance free, creative and causative thinking
Course Content (Syllabus)
Historical overview. Cell: Procaryotic and eukaryotic cells. Morphology. Chemical components of cells. Microorganisms. Important cell types. Cell cultures (animal, plant and microbial). Kinetics of cell growth-Equations. Methods for determination of cell growth. Enzymes. Kinetics of enzyme-catalyzed reactions. Michaelis-Menten equation. Briggs-Haldone kinetics. Evaluations of parameters in the Michaelis-Menten equation. Effect of pH and tempwrature on Enzyme kinetics. Order of enzyme-catalyzed reaction. Inhibition. Reversible inhibition. Competitive and non competitive inhibition. Immobilized enzymes and applications: Methods for immobilization. Examples. Applications of immobilized enzymes in industry. Production of L-amino acids with immobilized. a-amino acylase, β-galactosidase for hydrolysis of lactose, semi synthetic penicillins. Commercial immobilized enzymes. Sterilization: Methods of sterilization. Heat, chemical reagents, mechanical methods, ultrasound. Sterilization by heating. Continuous and non continuous sterilization. Bioreactors: Types of bioreactors. Productivity and designing of bioreactors. Factors influencing the operation of a bioreactor. Bioseparations-Dowbstream processing: General. Broth handling Seperation of liquid-solid. Filtration, Centrifugation. Cell lysis (Chemical, Enzymic and Physical methods). Product recaovery: Extraction. Adsorption. Product purification: Precipitation, Electrophoresis, Chromatography ion exchange, affinity and gell permeation chromatography). Ultrafiltration. Biotechnological applications. Synthesis and modification of polymers. Proteins and polypeptides Oligo- and polysaccharides. Degradation of starch by enzymes. Single cell proteins. Biosensors of proteins.
Microorganisms, Immobilized enzymes, Bioseparations-Dowbstream processing, Biotechnological applications
Educational Material Types
  • Notes
  • Slide presentations
  • Multimedia
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Communication with Students
Course Organization
Reading Assigment90
Student Assessment
Student Assessment methods
  • Written Assignment (Formative, Summative)
  • Oral Exams (Formative, Summative)
  • Written Exam with Problem Solving (Formative, Summative)
Course Bibliography (Eudoxus)
1. Μ. Λιακοπούλου-Κυριακίδου, 'Βιοτεχνολογία με στοιχεία Βιοχημικής Μηχανικής', Εκδόσεις Ζήτη, 2017
Additional bibliography for study
1. Biochemical Engineering and Biotechnology Ghasem Najafpour Elsevier Science 2006 2. Future Trends in Biotechnology Chikara Furusawa, Takaaki Horinouchi, Takashi Hirasawa (auth.), Jian-Jiang Zhong (eds.) Advances in Biochemical Engineering/Biotechnology 131 Springer-Verlag Berlin Heidelberg 2013
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