Pharmaceutical Chemistry of Elements and of the Inorganic Compounds

Course Information
TitleΦαρμακευτική Χημεία Στοιχείων και Ανόργανων Ενώσεων / Pharmaceutical Chemistry of Elements and of the Inorganic Compounds
FacultyHealth Sciences
Cycle / Level1st / Undergraduate
Teaching PeriodWinter/Spring
Course ID600013722

Programme of Study: PPS Tmīmatos Farmakeutikīs (2018-)

Registered students: 156
OrientationAttendance TypeSemesterYearECTS
KORMOSCompulsory Course117

Class Information
Academic Year2019 – 2020
Class PeriodWinter
Faculty Instructors
Weekly Hours5
Class ID
Course Type 2011-2015
Specific Foundation / Core
Mode of Delivery
  • Face to face
The course is also offered to exchange programme students.
Language of Instruction
  • Greek (Instruction, Examination)
Learning Outcomes
By successfully completing the course the students are expected to be able to: Locate the position in the table of periodicity of elements by their atomic number. Write the electronic structure of elements and monoatomic ions. Write the correct Lewis structures for simple and moderately compex compounds. Determine the hybridization of atoms and consequently the structure of small and medium sized molecules. Determine the bonding and the possible intermolecular interactions between small and medium sized molecules. Understand the basics of thermodynamics and spectroscopy. Be familiar with concepts of : a) biological activity of metals, nonmetals, metalloids, b) inorganic compounds with pharmaceuticals applications, c) interactions of these inorganic compounds with the biologicals targets and d) methods of identification, purity and quantitative analysis.
General Competences
  • Apply knowledge in practice
  • Retrieve, analyse and synthesise data and information, with the use of necessary technologies
  • Make decisions
  • Work autonomously
  • Work in teams
  • Advance free, creative and causative thinking
Course Content (Syllabus)
Atomic model: Initial atomic models – quantum description – current state of atomic theory. Atomic wave functions for hydrogen atom and simple applications of the atomic theory. Periodic properties of the atoms: Periodic table. Periodic properties of the elements – atomic radius – ionization energy – electron affinity – electronegativity. Understanding of the periodic properties through atomic theory. Determination of the electronic configuration of atoms – stable electronic structures. Description of the chemical bond: Formation of simple molecules. Valence bond approximation. Bond description based on molecular orbitals. Covalent bonds. Description of polyatomic molecules – hybridization – VSEPR theory. Molecules with π bonds – aromatic systems. Energy and polarization of a covalent bond. Structure and interactions of macromolecules. Ionic bond – hydrogen bond – other electrostatic interactions. Metal compounds: General considerations. Classification of metal coordination compounds. Bond theories in coordination compounds. Optical and magnetic properties of coordination compounds. Isomerism in coordination compounds. Elements of molecular spectroscopy: General principles of spectroscopy. Electronic, vibrational, magnetic resonance and photoelectron spectroscopy. Principles and applications in the identification of chemical compounds. Description of the gaseous state: Brief description of the laws of gases and the kinetic theory of gases. Reactions in the gas state. Elements of chemical thermodynamics: General considerations. Enthalpy, entropy and free energy. Chemical properties of elements in groups: Elements of the S, P and D blocks of the periodic table. Descriptive presentation of their general chemical properties and some physical properties of their compounds. Inspection of elements in respect with Chemistry-Pharmacological/Toxicological activity, biological activity of metals-metalloids, inorganic compounds of pharmaceutical interest: synthesis/origin, quality/quantity control, properties, uses, side effects and their chemical explanation. The given knowledge contains inorganic drugs that are still in used. Inorganic drugs that are no longer in use are also presented from a historical perspective. The categories of drugs discussed include antipsychotics, antiseptics, antacids, electrolytes, diagnostic, etc. The course is accompanied by a set of laboratory experiments which include: Rules of good laboratory practice. Categories of chemical reactions – product identification. Chemical equilibrium in solution. Homogeneous and heterogeneous reactions and means to alter their equilibrium. Weak electrolyte dissociation, determination of the pK of a weak acid. pH indicators and their use. Preparation and study of a buffer solution. Elements of redox chemistry. Oxidative and reductive properties of some compounds. Galvanic cells. Principles of visible spectroscopy. Application of visible spectroscopy in the identification and quantification of chemical compounds. Principles of volumetric analysis. Volumetric techniques in the determination of acid-base or metal content of a solution.
General Chemistry, Inorganic Chemistry, Inorganic Medicinal Chemistry
Educational Material Types
  • Notes
  • Book
Use of Information and Communication Technologies
Use of ICT
  • Use of ICT in Course Teaching
  • Use of ICT in Communication with Students
Powerpoint slides are used in the lectures which are also available for the students in the elearning website of the course.
Course Organization
Laboratory Work21
Written assigments6
Student Assessment
Evaluation of the students on theory based on the lectures in a written exam at the end of the semester (80%) and evaluation of the students on the laboratory practice (20%) and in particular their lab conduct and the results obtained during the lab experiments. Examination is based on some questions which should be answered according to the obtained knowledge during semester as well as to the ability to combine knowledge with information and the critical thought of the students. Exams at the end of semester take place on date and hours as well as in auditoriums announced by the Department, with duration of 3 hours.
Student Assessment methods
  • Written Exam with Multiple Choice Questions (Summative)
  • Written Exam with Short Answer Questions (Summative)
  • Written Exam with Problem Solving (Summative)
  • Labortatory Assignment (Summative)
Course Bibliography (Eudoxus)
Στοιχεία Γενικής Χημείας. Θεωρία και Πειράματα. Π. Ακρίβος, Α. Χατζηδημητρίου. Εκδόσεις ΖΗΤΗ, Θεσσαλονίκη, 2012, 1η έκδοση, ISBN 978-960-456-333-3, Κωδικός στο σύστημα «Εύδοξος» 22766674
Additional bibliography for study
Σημειώσεις Ανόργανης Φαρμακευτικής Χημείας Ε. Ποντίκη και Δ. Παπαγιαννοπούλου Remingtons: Pharmaceutical Sciences 14 Ed.Mac.Publishing Co., Easton, 1970. Εθνικό συνταγολόγιο Εκδόσεις Εθνικός Οργανισμός Φαρμάκων 2007
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