After completing the course, the students will be able to understand the basic concepts of 1) pharmacokinetics - to the extent that they are able to perform simple pharmacokinetic calculations (e.g., loading dose, maintenance dose) and can estimate the probability of drug-drug interactions, 2) pharmacodynamics, so that they understand the concept of agonism and antagonism, as well as the relation between mechanism of action, efficacy, toxicity, clinical utility, indications, contra-indications, adverse reactions, and pharmacodynamic drug-drug interactions, and 3) the basic properties (pharmacokinetics, mechanism of action, indications, adverse effects, contraindications) of drugs acting on the parasympathetic and sympathetic nervous system, so that they can understand better their clinical utility in future courses and administer them safely in clinical praxis. They will be able to appreciate the significance of pharmacological modulation of chemical mediators in preparation for the studying of Systemic Pharmacology in future semesters. They will have become familiar with the effects of age, comorbidity, polypharmacy, and interindividual variability on drug action.
Course Content (Syllabus)
Introductory concepts-Pharmacodynamics-Mechanisms of drug action; Pharmacokinetics; Drug-drug interactions-adverse effects and drug toxicity; Methodology and measurements; Drug discovery and development; Biopharmaceuticals; Gene therapy and cell therapy; Special groups of patients; Interindividual variability; Pharmacogenetics; Chemical mediators and cholinergic drugs; Chemical mediators and adrenergic drugs; Other chemical mediators-serine, adenosine, adenine nucleotides, NAD; Topical hormones; Neurotransmitters; Cannabinoids; Peptide/protein mediators-gaseous mediators; Drug abuse and dependence
pharmacological concepts and definitions, pharmacokinetics, pharmacodynamics, agonist, antagonist, drug-drug interactions, adverse effects, pharmacogenetics, adrenergic, cholinergic, chemical mediators, drug dependence
Course Bibliography (Eudoxus)
ΦΑΡΜΑΚΟΛΟΓΙΑ, Humphrey G. Rang, James M. Ritter, Rod Flower, Graeme Henderson, Έκδοση: 8η/2018, ΕΚΔΟΣΕΙΣ ΠΑΡΙΣΙΑΝΟΥ, ΑΘΗΝΑ
2. GOODMAN & GILLMANS Η ΦΑΡΜΑΚΟΛΟΓΙΚΗ ΒΑΣΗ ΤΗΣ ΘΕΡΑΠΕΥΤΙΚΗΣ, Έκδοση: 2η έκδ./2015, Συγγραφείς: Brunton L. ΕΚΔΟΣΕΙΣ BROKEN HILL PUBLISHERS LTD, ΑΘΗΝΑ 2015
3. ΦΑΡΜΑΚΟΛΟΓΙΑ, Έκδοση: 6η/2015, Συγγραφείς: HARVEY A. RICHARD,KAREN WHALEN,RICH.FINKEL,TH.A.PANAVELIL, ΕΚΔΟΣΕΙΣ ΠΑΡΙΣΙΑΝΟΥ, ΑΘΗΝΑ 2015