Design of Manufacturing Processes for Pharmaceutical products
| Title | Σχεδιασμός Βιομηχανικών Μονάδων Παραγωγής Φαρμάκων / Design of Manufacturing Processes for Pharmaceutical products |
| Code | ΣΒ2 |
| Faculty | Engineering |
| School | Chemical Engineering |
| Cycle / Level | 2nd / Postgraduate |
| Teaching Period | Winter/Spring |
| Coordinator | Christos Chatzidoukas |
| Common | No |
| Status | Active |
| Course ID | 600023192 |
Programme of Study: MSc Chemical and Biochemical Engineering: Health & Food
Registered students: 0
| Orientation | Attendance Type | Semester | Year | ECTS |
|---|---|---|---|---|
| KORMOS | Compulsory Course | 2 | 1 | 7.5 |
| Academic Year | 2024 – 2025 |
| Class Period | Spring |
| Faculty Instructors | |
| Class ID | 600245284
|
Type Of Offer
- Disciplinary Course
Course Type 2021
Specific Foundation
Mode of Delivery
- Face to face
Digital Course Content
- e-Study Guide https://qa.auth.gr/en/class/1/600245284
- eLearning (Moodle): https://elearning.auth.gr/course/view.php?id=11013
Language of Instruction
- Greek (Instruction, Examination)
- English (Instruction, Examination)
Prerequisites
Required Courses
- ΑΔ1 Process analysis
- ΕΔ1 Data mining and numerical analysis
General Prerequisites
background knowledge
Learning Outcomes
Upon successful completion of the module, students will be able to:
- Identify all unit operations comprising a typical cell-based manufacturing process as well as possible facility layouts depending on the properties of the manufactured product and the type of cells employed
- Formulate and solve mass and energy balances for each unit operation in a typical cell-based manufacturing process
- Perform scaling calculations between lab, pilot and commercial scale equipment
- Design downstream unit operations
- Simulation of biopharmaceutical manufacturing processes
General Competences
- Apply knowledge in practice
- Retrieve, analyse and synthesise data and information, with the use of necessary technologies
- Adapt to new situations
- Make decisions
- Work autonomously
- Work in teams
- Work in an interdisciplinary team
- Be critical and self-critical
Course Content (Syllabus)
• Overview of a manufacturing process flowsheet - Mass Balances - Component and stream composition - Introduction to the case study
• Cell growth in Erlenmeyer flasks and benchtop bioreactors in batch mode
• Bioreactor Design Ι
• Bioreactor Design ΙΙ
• Oxygen mass transfer(kLa)
• Model based scale-up study (Bench -top to pilot scale, operating & aeration policies)
• Centrifugation & Downstream Separations
• Extraction - Crystallization I
• Extraction - Crystallization II
• Fluidized bed drying
• Whole bioprocess simulation Ι
• Whole bioprocess simulation ΙΙ
• Laboratory exercises: Bioreactor Run I, Bioreactor Run II
Keywords
Biochemical Engineering, Bioprocess Simulation
Educational Material Types
- Notes
- Slide presentations
- Book
Use of Information and Communication Technologies
Use of ICT
- Use of ICT in Course Teaching
- Use of ICT in Laboratory Teaching
Course Organization
| Activities | Workload | ECTS | Individual | Teamwork | Erasmus |
|---|---|---|---|---|---|
| Lectures | 15 | 0.5 | ✓ | ||
| Laboratory Work | 6 | 0.2 | ✓ | ||
| Reading Assigment | 60 | 2 | ✓ | ||
| Interactive Teaching in Information Center | 18 | 0.6 | ✓ | ||
| Project | 90 | 3 | ✓ | ||
| Written assigments | 36 | 1.2 | ✓ | ✓ | |
| Total | 225 | 7.5 |
Student Assessment
Student Assessment methods
- Written Assignment (Summative)
- Performance / Staging (Summative)
Bibliography
Course Bibliography (Eudoxus)
Doran, Pauline M. Bioprocess Engineering Principles: Pauline M. Doran. London ; San Diego: Academic Press, 1995
Additional bibliography for study
Bailey, James E. 1944-, και David F. Ollis. Biochemical Engineering Fundamentals. 2nd ed. New York: McGraw-Hill, 1986
Last Update
03-06-2025
