Learning Outcomes
The students are expected to, within the framework of the course, (1) understand the basic principles of computational modeling, (2) connect theory with practice through the application of computational experiments, (3) be able to adapt electrophysiological models to pathophysiological conditions in order to perform simulations at both microscopic and macroscopic levels, (4) comprehend the mechanisms of function and pathology of the human body systems.
Course Content (Syllabus)
Introduction to modeling theory
System modeling methods
cardiac electrophysιology - cell models and propagation
Cardiac models/ practical experience
cardiac conduction model (hand on experience)
In silico modeling of cardiac electrophysiology
cardiac conduction model / chaste cell+ 1D example / 2D example
In Silico Modelling and clinical applications / practical experience
Introduction to Biological modelling and bioinformatics approaches
biological processes - metabolomics & systems biology
Additional bibliography for study
J. Malmivuo, R. Plonsey, 'Bioelectromagnetism''
G.D. Smith 'Solutions of Partial Differential equations using finite difference methods'' Oxford Press
J. Jack, D. Noble and Smith '' Electric current flow in excitable cells'' Oxford Press
Mathematically Modelling the Electrical Activity of the Heart: From Cell to Body Surface and Back Again
By (author): Andrew J Pullan (University of Auckland, New Zealand), Leo K Cheng (University of Auckland, New Zealand), Martin L Buist (University of Auckland, New Zealand & National University of Singapore, Singapore)
A series of ebooks for data driven modelling
Selected papers from published literature, periodically updated