Learning Outcomes
At the end of the course students will be able to:
• Comprehend SMART drug delivery systems at the nano and microlevel
• Design and prepare drug delivery systems as technological tools for clinical applications
• Apply basic engineering principles for the design of spray and freeze-drying equipment
• Explain the basic principles behind encapsulation techniques for drug delivery systems
• Discern, select and implement material-specific formulations linked to bio-responsive drug delivery systems
• Explain the basic principles behind different mechanisms of drug absorption and specified molecular target action
• Master calculations of pharmacokinetic and pharmacodynamic properties of drug candidates
• Give a broad account of the analytical methodologies necessary for control of the purity of the final drug product.
Course Content (Syllabus)
This multi-disciplinary course aims at introducing graduate students to the field of drug engineering. The course will provide detailed knowledge on: basic engineering of bioresponsive materials for the design and implementation of drug delivery systems, development of SMART delivery processes linked to clinical applications, general principles and applications of lab-to-clinic nano/micro-technology transfer, principles of spray drying and freeze drying technologies, encapsulation techniques, engineering drug delivery systems at the nano and micro level, physicochemical and biological characterization of drug delivery systems and their targeted clinical correlations, the pharmacokinetic and pharmacodynamic principles, analytical methods for validation, film coating technology, and oral strip manufacturing technology.
Description
1. Online Learning Platforms: Platforms, like e-learning or Moodle are used to distribute course material, post announcements, manage assignments, and facilitate discussion.
2. Project Collaboration Tools: Tools, like Skype, Microsoft Teams or Google Workspace are used for collaborative project work, allowing students to communicate, share files, and work together effectively.
3. Digital Assessment: Online quizzes and exams are conducted using ICT. These platforms can provide immediate feedback, helping students to learn and improve.
4. Research and Information Gathering: Online databases and academic search engines are used for research and gathering information for projects and assignments.
These are just a few examples, and the actual use of ICT depends on the specific needs and resources of the course.
Description
1. Understanding and Application of Knowledge: This is assessed through exams and quizzes to evaluate student understanding of the course material and their ability to apply theoretical knowledge to practical problems.
2. Laboratory Skills: Student ability and dexterity to perform experiments, use equipment, follow safety protocols, and interpret results in the laboratory can be evaluated.
3. Project Work: The quality of student work on projects, including their problem-solving skills, creativity, and ability to work independently or as part of a team, can be assessed.
4. Report Writing: Student ability to effectively communicate their findings and ideas in written reports can be evaluated. That includes use of proper formatting, clear and concise language, and appropriate citations.
These criteria aim to ensure comprehensive evaluation of student academic and practical skills in the field of biomedical engineering.
Additional bibliography for study
1. Engineering Drug Delivery Systems, Edited by A. Seyfoddin, S. M. Dezfooli, C. A. Greene, Woodhead Publishing, Elsevier, U.K. 2020.
2. Drug Delivery. An Integrated Clinical and Engineering Approach, Edited by Y. Rosen, P. Gurman, N. M. Elman, CRC Press, Taylor & Francis Group, N.Y. 2017