Design, development and pharmacological evaluation of active drug molecules – Preformulation studies

General Foundation

Understanding by the students of druglikeness, design of lead compounds, quantitative structure activity relationships, prediction and modelling of solid state, physicomechanical properties of powders, preformulation/formulation, polymorphism, Design of targeted radiopharmaceuticals (radiotracers), diagnostioc radionuclides fro SPECT and therapeutical radionuclides, anticancer drugs and principles of pharmacogenomics, synthesis, design and evaluation of pharmaceutical products drugs, Good Manufacturing Procedures, Good distribution practice. The students will gain a global experience of the requirements/difficulties correlated with the drug, a product of high technological research. Application of knowledge in praxis. Search, analysis, data and information combination by the use of necessary technologies.

• Quantitative structure activity relationships (QSAR), Physicochemical properties of powder, Chemometrics, Simulation, Fundamentals, Examples of 2D and 3D-QSAR relationships for various molecular targets. • ADMET models. Simulation models. • Physico-mechanical properties of powders (size, shape, flow, compressibility). • Solid phase selection – Polymorphism control. • Computational simulation of the solid state (prediction, crystal polymorphism, estimation of mechanical properties, prediction of crystal morphology). • Evidence of anticancer drug development. Pharmacological and pharmacogenomic approach. • Design, Production and Quality Control of Radiopharmaceutical (pre) Formulations. Development of production methods and quality control of radiopharmaceutical preparations. • Study of preformulation-formulation in modern pharmaceutical forms. • Design and development of products: Selection of excipients and factors that determine them in the production of solid pharmaceutical products (Tablets). • Drug design to avoid toxicity.

28-02-2024