Curriculum Vitae

Ioannis Vizirianakis

Professor, School of Pharmacy

Personal Information

- 2310997658
ivizir@pharm.auth.gr
http://www.pharm.auth.gr/vizirianakis/
Scopus ID6701758622
https://orcid.org/0000-0003-1459-9774
Γνωστικό Αντικείμενο:
Μοριακή Φαρμακολογία-Φαρμακογονιδιωματική
Επιστημονική Ειδίκευση: ΦαρμακευτικήΜοριακή Φαρμακολογία

Education

Προπτυχιακές Σπουδές

1981	Πτυχίο Φαρμακευτικής Φαρμακευτικής Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης Greece

Διδακτορικό Δίπλωμα

1991	Διδακτορικό δίπλωμα Φαρμακευτικής Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης Greece Βιοχημική & Μοριακή Φαρμακολογία

Course Work

Courses of Winter semester of 2026–27 academic year

	SCHOOL OF PHARMACY
49	PHARMACOLOGY I
ΝΠ18-37	Pharmacology I
ΝΠ18-Δ1	Diploma Thesis 1/2
ΝΠ18-Δ2	Diploma Thesis 2/2
ΠΑ-1	Practical Training I

	POSTGRADUATE STUDIES PROGRAMME OF THE SCHOOL OF PHARMACY "INDUSTRIAL PHARMACY"
ΠΜΣΒΦ-001	Design, development and pharmacological evaluation of active drug molecules – Preformulation studies
ΠΜΣΒΦ-003	Preclinical and Clinical evaluation of drugs
ΠΜΣΒΦ-004	1st stage of elaboration of diploma thesis
ΠΜΣΒΦ-008	2nd stage of elaboration of diploma thesis
ΠΜΣΒΦ-009	Regulatory affairs for the approval of medicines and clinical trials
ΠΜΣΒΦ-010	3rd stage of elaboration of diploma thesis
ΠΜΣΒΦ-Μ1	Design, development and pharmacological evaluation of active drug molecules – Preformulation studies
ΠΜΣΒΦ-Μ3	Preclinical and Clinical evaluation of drugs
ΠΜΣΒΦ-Μ7	Regulatory affairs for the approval of medicines and clinical trials

	POSTGRADUATE STUDIES PROGRAMME "PRECISION MEDICINE - TRANSLATION RESEARCH AND THERAPEUTICS"
ΙΑΑ04	Pharmacogenomics
ΙΑΓ01-ΕΑ 3	Rotation 3

	Msc in "Applied Microbiology"
ΜΙΜΙΚΑ004	Modern laboratory methodologies – Molecular diagnosis in Medical Microbiology

	POSTGRADUATE STUDIES PROGRAMME OF THE SCHOOL OF PHARMACY "DRUG DEVELOPMENT, DIAGNOSTIC AND THERAPEUTIC"
ΠΜΣΦΓΝ-003	Pharmacological controls

	Farmakochīmikī kai Farmakologikī Anáptyxī Farmakomoríōn
ΦΦΑΦ-02	Molecular Pharmacology

Courses of Spring semester of 2026–27 academic year

	SCHOOL OF PHARMACY
79	CLINICAL PHARMACOKINETICS
ΔΕ1	DIPLOMA THESIS 1/2
ΔΕ2	DIPLOMA THESIS 2/2
ΝΠ18-48	Clinical Pharmacokinetics
ΝΠ18-58	Pharmacogenomics and Personalised Medicine
ΝΠ18-Δ1	Diploma Thesis 1/2
ΝΠ18-Δ2	Diploma Thesis 2/2
ΠΑ-2	Practical Training II

	POSTGRADUATE STUDIES PROGRAMME "RESEARCH METHODOLOGY IN MEDICINE AND IN HEALTH SCIENCES"
ΙΜΒ033	Preclinical Studies in Drug Development

	POSTGRADUATE STUDIES PROGRAMME "PRECISION MEDICINE - TRANSLATION RESEARCH AND THERAPEUTICS"
ΙΑΒ01	Innovative Therapies and regulatory framework
ΙΑΒ04	Modern methodology in drug research)

	POSTGRADUATE STUDIES PROGRAMME "MEDICAL CLINICAL AND INDUSTRIAL PHARMACOLOGY - CLINICAL TOXICOLOGY"
ΜΙΦΒ0030	General Toxicology

	POSTGRADUATE STUDIES PROGRAMME OF THE SCHOOL OF PHARMACY "INDUSTRIAL PHARMACY"
ΠΜΣΒΦ-Μ1	Design, development and pharmacological evaluation of active drug molecules – Preformulation studies
ΠΜΣΒΦ-Μ10	2nd stage of elaboration of diploma thesis
ΠΜΣΒΦ-Μ3	Preclinical and Clinical evaluation of drugs
ΠΜΣΒΦ-Μ7	Regulatory affairs for the approval of medicines and clinical trials
ΠΜΣΒΦ-Μ9	1st stage of elaboration of diploma thesis

Theses Supervised

Student Theses within AUTh

In progress

Undergraduate

Pharmacogenomics and Personalized Medicine in Alzheimer's Disease
Pharmacogenomics and personalized medicine in Multiple Sclerosis
Pharmacogenomics and precision medicine in Acute Myeloid Leukemia: Patient stratification, biomarkers and targeted therapeutic approaches
No title
Clinical implementation of pharmacogenomic data for the improvement of pharmacotherapy of antidepressant drugs
Pharmacogenomics and personalized medicine in Crohn's disease
Pharmacogenomics and personalised medicine of lung cancer adenocarcinoma
Pharmacogenomics of aromatase inhibitors: challenges and perspectives for personalized Cancer Medicine
Pharmacogenomics of EGFR tyrosine kinase inhibitors: Challenges and perspectives for personalized cancer therapy
Pharmacogenomics of drugs induced liver indury (D.I.L.I.)
Pharmacogenomics of Crohn's disease
Pharmacogenomics of multiple sclerosis
Pharmacology and Therapeutics of Atheromatosis from the perspective of Pharmacogenomics
Pharmacogenomic analysis of β-adrenergic blockers and clinical use of the data in the treatment of cardiovascular diseases
No title
No title
No title

Postgraduate

Precision Medicine in Targeted Anticancer Therapies Independent of the Histological Origin of the Tumor (Tumor-Agnostic Therapies)
Economic evaluation and clinical utility of Liquid Biopsy in Precision Medicine: A literature review
Assessment of differentiation capacity of human erythroleukemia K562 cells upon silencing gene expression of STEAP3
No title

Doctoral

Exploitation of exosomes and vesicle-mimetics of exosomes as delivery systems of therapeutics for selective targeting of cancer cells
Exosome mimetic nanovesicles as bio-inspired delivery systems of therapeutic modalities for the molecular targeting of cancer cells
No title
No title

Unknown

Undergraduate

PHARMACOGENEMIC APPROACH OF THE DOXORUBICIN-INDUCED CARDIOTOXICITY IN ANTICANCER THERAPEUTIC SCHEMES

2025–2026

Undergraduate

Biomarkers in resistant depression
Pharmacogenomics and Precision Medicine of non-small lung cancer
Pharmacogenomics and Precision Medicine of Schizophrenia
Drug-induced cardiotoxicity and elongation of QT: Prospects and challenges for pharmaceutical care
Comparative pharmacogenomics analysis of Parkinson's and Huntington's disease: Challenges and perspectives for personalized medicine
Comparative analysis of digital marketing and drug delivery in the pharmaceutical market and public health: perspectives and socioeconomic challenges
Pharmacogenomics and interactions of antidiabetic drugs
Pharmacogenomics and interactions of tricyclic antidepressants
Pharmacogenomics and interactions of tricyclic antidepressants drugs
Pharmacogenomics and personalized medicine of breast cancer
Pharmacogenomics and Pharmacokinetics of Antihypertensive Drugs with Clinical Interest
Pharmacological and pharmacogenomics analysis of drugs used to treat neurological pain: Challenges and perspectives for personalized therapy
Ιnteractions and pharmacogenomics data analysis of antipsychotic drugs
Therapeutics and pharmacology in the light of pharmacogenomics
Pharmacology, Pharmacogenomics and Precision Medicine of rheumatoid arthritis
Pharmacological and pharmacogenomics assessment of antidiabetic drug data
Tongue Cancer and Molecular Prognostic Signature: Systematic Review of Bibliography
Pharmacological and pharmacogenomics data assessment of tyrosine kinase inhibitors

Postgraduate

Optimizing Targeted Therapeutic Strategies in Neuroblastoma
No title
Study of cytotoxicity and inhibitory action on tyrosinase of new tropolone derivatives in B16F10 melanoma cells
Pharmacogenomics and precision medicine in Alzheimer and Parkinson's diseases.
Pharmacological assessment of new tropolone derivatives in B16-F10 melanoma cells.
No title
Modern approaches to molecular diagnosis and pharmacogenomic data analysis in Alzheimer's Disease
Pharmacological assessment of new N-aryl-tropolone derivatives in erythroleukemia cell cultures

Doctoral

Assessment of the effects of extra virgin olive oil on improving symptoms of Alzheimer's disease by molecular, pharmacological, and clinical approaches
Molecular Analysis Of The Ribosome Transcriptome During Erythropoiesis And -Omics Analysis For Pharmacological Exploitation In Ribosomopathies

2024–2025

Undergraduate

Pharmacogenomics and interactions of antidiabetic drugs
Interactions and pharmacogenomics of antihypertensive drugs
Evaluation and implementation of pharmacogenomic guidelines on prescribing for tricyclic antidepressants and selective serotonin reuptake inhibitors
Assessing the pharmacological and pharmacogenomic data of PD-1/PD-L1 inhibitors to enhance cancer immunotherapy outcomes in the clinical setting
Cytotoxicity assessment of new synthetic thiazolidinones with activity against SARS-CoV-2 virus in cell cultures
The Brugada Syndrome: Pathophysiology, Pharmacology and Pharmacogenomics
Pharmacogenomics and Precision Medicine in breast cancer therapy
Pharmacogenomics of heart failure: Challenges and perspectives for personalised medicine
Pharmacological and pharmacogenomics data analysis of tamoxifen for implementation intherapeuticals
Pharmacological and pharmacogenomics data analysis of anticoagulant and antiplatelet drugs: Challenges and perpectives in therapeutics
Review on lung cancer and the contribution of pharmacogenomics and precision medicine in its effective treatment
Adaptive responses of E. Coli under Colistin and Bacteriophage coevolutionary selective pressure

Postgraduate

Isolation and characterization of mucins from sputum from asthmatic patients.
Assessment of cytotoxicity of new N-aryl-imino-tropolone derivatives in erythroleukemia cell cultures
No title
Pharmacological assessment of olive oil ingredients using cell cultures and techniques of molecular analysis of gene expression.
No title

2023–2024

Undergraduate

Nanomedicine and Precision Medicine: Challenges and Prospects in Pharmacology and Therapeutics
Pharmacogenomics and clinical assessment of tyrosine kinase inhibitors in chronic myeloid leukemia therapy
Analysis of antidepressants' drugs interactions in clinical practice
Analysis of the cardiotoxicity of non-cardiovascular drugs
Enzymatic analysis of doxorubicin metabolism for the development of clinical pharmacokinetic models
Ethical dimensions, practical issues and the evolution of the informed consent form in clinical trials
No title
Pharmacological and pharmacogenomic evaluation of antidiabetic drug data
Pharmacogenomics and precision medicine for the treatment of lung cancer

Postgraduate

Dealing with Class Imbalanced Problem for the Prediction of SYNTAX Score and Severity of Coronary Artery Disease
Pharmacological assessment of new synthesized sesquiterpene compounds in cell cultures
Pharmacological evaluation of new synthetic thiazole derivatives as antivirals for SARS-CoV-2
Pharmacological assessment at new synthesized sesquiterpene compounds for anti-cancer action in cancer HSC-3 cell lines
3D spheroid model of cancer cells to explore the chemoresistance and cell culture responses to anticancer drugs, by fluorescence microscopy
No title

Doctoral

Analysis of molecular mechanisms and phenotypes in biomimetic environment for exploitation in systems pharmacology and translational medicine

2022–2023

Undergraduate

Pharmacogenomics and precision medicine in colorectal cancer
Pharmacogenomic and pharmacological evaluation of antidepressant drugs
Discovery of cross-reactive antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins
The Pharmaceutical marketing in prescribed medicinal products
Pharmaceutical Marketing: Methods of medicine promotion, Legislative frameworks in Greece, Europe and the USA and Ethical frameworks for medicine advertising
Identifying potential biomarkers for Head and Neck Squamous Cell Carcinoma using Bioinformatics tools
Pharmacogenomic analysis of β-adrenergic blockers and clinical use of the data in the treatment of cardiovascular diseases

Postgraduate

CELL PERMEABILITY ASSESSMENT OF EXOSOMES FOR THEIR PHARMACEUTICAL EXPLOITATION TO DEVELOP INNOVATIVE THERAPEUTICS
Exploitation of cell cultures by using molecular methodologies for the pharamacological assessment of dietary supplements and pharmaceutical products
INVESTIGATION OF GENETIC POLYMORPHISMS IN THE APPEARANCE OF ANDROGENETIC ALOPECIA IN GREEK POPULATION
Pharmacogenetic Association Study with treatment response of psychotic patients in a naturalistic setting
Pharmacogenomics of antidiabetic drugs.
Antidiabetic drug interactions and pharmacogenomic assessment: Thei significance in clinical toxicology.
Cell-secreted exosomes and exosome-mimetic nanovesicles as drug delivery systems for cancer therapeutics: development, characterization and pharmacological assessment
Characterization and pharmacological evaluation of naturally-secreted and artificially-produced exosomes: Towards nanovesicle-based drug delivery in cancer treatment
Pharmacogenomic analysis to identify potential paclitaxel related biomarkers in pancreatic adenocarcinoma therapy
Pharmacogenomic exploitation of KRAS mutation at precision medicine of non-small cell lung cancer and new therapeutic approaches.
Pharmacological assesment and molecular evaluation cell cultures constituents of food supplements and pharmaceutical products

Doctoral

Isolation, characterization and therapeutic application on bacteriophages in a murine model of gastrointestinal colonization and translocation of multidrug resistant Klebsiella pneumoniae

2021–2022

Undergraduate

PPRHs as a cancer therapy approach
Pharmacogenomics of antidepressant and antipsychotic medications
Pharmacological assessment of new amino-2-thiazole chemical compounds

Doctoral

No title

2020–2021

Undergraduate

Novel research models of Parkinson's diseace
Overexpression and pharmacological avaluation of miR-16-5p and miR-129-5p in cancer cell lines
Pharmacogenomic analysis for prediction of pharmacological response to gemcitabine in Glioblastoma Multiforme treatment
Isolation and pharmacological exploitation of exosomes as transport systems of therapeutics
Construction of recombinant plasmid vectors to modify the expression of microRNAs in eukaryotic cells
Pharmacogenomic analysis for prediction of pharmacological response to doxorubicin in Lung Adenocarcinoma treatment.
Pharmacogenomic analysis of the pharmacological response to Luminespib in the treatment of breast cancer
Pharmacogenomic Approach of SSRIs in order to Enhance Clinical Action
PGxSnake: End-to-end bioinformatics tool for the accurate identification of germline variants and the generation of personalized pharmacogenetics reports
Implementation process and molecular analysis of 3D cell cultures in new drug development
Study of the effect of the long term infliximab on mRNA levels of the HSC70 gene in the hypothalamus and preffrontal cortex
Preclinical study of hypothalamic and PFC HSC70 expression levels, after long-term administration of tocilizumab
INNOVATIVE MOLECULAR DIAGNOSTICS AND PHARMACOLOGICAL APPROACHES TO THE TREATMENT OF MULTIPLE SCLEROSIS

Postgraduate

No title
No title
No title

Doctoral

No title

2019–2020

Undergraduate

Population pharmacokinetics of ganciclovir and valganciclovir: Comparison of three renal function PopPK models
Pharmacological assessment of new pyrrole-based heterocyclic compounds as anticancer therapeutics
Pharmacological Evaluation of sesquiterpene compounds for their anticancer activity.

Postgraduate

No title

Doctoral

No title

2018–2019

Undergraduate

Impact of PREP and its inhibition to a cell model of Multiple System Atrophy
TFIP11 and DHX15: splicing factors involved in the late stage of splicing and in cell survival - A potential cancer therapy
Involvement of calpain/nox pathway in the response of glioblastoma to cis-platin
Sesquiterpene compounds pharmacological evaluation for antineoplasmatic action
Pharmacodynamics and pharmacοgenomics of the antiplatelet effect of warfarin, aspirin, clopidogrel and dabigatran.

Postgraduate

No title
No title

2017–2018

Undergraduate

CANCER IMMUNOTHERAPY: NEW THERAPEYTIC APPROACHES AND EXPERIMENTAL APPLICATIONS IN THE TREATMENT OF MELANOMA WITH ONCOLYTIC ADENOVIRUSES
Biophysical screening of novel BRD4 (BD1) inhibitors able to displace binding site water molecules
Therapeutics of Head and Neck Squamous Cell Carcinoma: Personalized Medicine and Molecular Profiling
No title

2016–2017

Undergraduate

Drug-induced Cardiotoxicity: Assessment of pharmacological, clinical & pharmacogenomics data
INNOVATIVE THERAPEUTIC APPROACHES AND NEW TARGETED DRUG DEVELOPMENT FOR PERSONALIZED CANCER MEDICINE

Postgraduate

No title

2014–2015

Undergraduate

Effect of DLK Y343 mutants on kinase activity
ASSESSMENT OF CELLULAR PROLIFERATION AND DIFFERENTIATION POTENTIAL OF CLONE MEL-B10 STABLY-TRANSFECTED WITH RPL35a
ASSESSMENT OF PROLIFERATION AND DIFFERENTIATION POTENTIAL OF CLONE MEL-B3, OVEREXPRESSING RIBOSOMAL PROTEIN L35a
ASSESSMENT OF PROLIFERATION AND DIFFERENTIATION POTENTIAL OF CLONE MEL-F2 OVEREXPRESSING RPL35a
ASSESSMENT OF CELLULAR PROLIFERATION AND DIFFERENTIATION POTENTIAL OF CLONE MEL-G7 OVEREXPRESSING RPL35a RIBOSOMAL PROTEIN
Implementation of PBPK modeling in therapeutics: Toward personalizing antibiotics delivery

Postgraduate

THE PHARMACOLOGICAL DEVELOPMENT OF INNOVATIVE BIFUNCTIONAL CARBRANES FOR BORON NEUTRON CAPTURE THERAPY (BNCT) OF CANCER

Doctoral

No title

2013–2014

Undergraduate

PHARMACOLOGICAL ASSESMENTOF NEW 4-HYDROXYL-2-PYRIDONES IN THE MURINE ERYTROLEUKEMIA (MEL) CELL MODEL SYSTEM
EXPLOITATION OF MURINE ERYTHROLEUKEMIA (MEL) CELL MODEL SYSTEM FOR THE PHARMACOLOGICAL ASESSMENT OF NEW 4-HYDROXY-2PYRIDONE ANALOGUES
IMPLEMENTATION OF Simcyp® SIMULATOR TO ASSES THE CLINICAL VALIDITY OF POPULATION PHARMACOKINETICS DATA OF ANGIOTENSIN II RECEPTOR INHIBITORS

Postgraduate

PHARMACOLOGICAL EVALUATION OF NEW CARBORANE COMPOUNDS FOR BORON NEUTRON CAPTURE THERAPY (BNCT) OF CANCER

2015–2016

Postgraduate

Investigation of the role of EZH2 methyltransferase in Chronic Lymphocytic Leukemia
“Pharmacological assessment of new sesquiterpenoids derivatives for anticancer activity”
Development and Pharmacological evaluation of chitosan nanoparticles for renal drug delivery

2011–2012

Postgraduate

No title

2010–2011

Postgraduate

No title
No title

2008–2009

Postgraduate

No title
No title

2005–2006

Postgraduate

No title

Administrative Work

Άλλο
#	Από	Έως	Θέση Περιγραφή
1	2005	2011	Μέλος επιτροπής Φαρμακοεπαγρύπνησης του ΕΟΦ

Research Projects

Participant
2024–2025	Cutting-edge therapies for skin inflammation
2022–2027	MSc “Applied Microbiology”
2022–2025	Enhancing the added value of the agri-food sector of the Region of Central Macedonia - innovative products and applications based on oregano and oregano oil
2020–2028	Precision Medicine-Translational Research and therapeutics
2019–2020
2018–2027	Postgraduate programme: Industrial pharmacy
2018–2027	Master's Program “Clinical and Industrial Pharmacology - Clinical Toxicology”
2018–2022	Development of a risk prediction algorithm through the Investigation of genetic risk factors and the complexity of coronary artery disease to estimate future risk of cardiovaskular events: angiographic (SYNTAX score), clinical and pharmacogenetic analysis
2018–2026
2018–2026
2016–2026
2014–2015	Microporous inorganic materials (zeolites) for the oral delivery of poorly soluble drugs.
2009–2017
2003–2008	Reconstuction of Undergraduate Studies Programme of the Pharmaceutical Dept. of Auth
2002–2008	Pharmaceutical Science
1998–2001	Ανάπτυξη και βιομηχανική παραγωγή (Scale-up Produ ctio) ανρωπίων ανασυνδιασμένων πρωτεϊνών θεραπευτικού ενδιαφέροντος ως προϊόντα βιοτεχνολογίας.
1998–2018	Καταθέσεις για πληρωμή μελών ΔΕΠ (3%) από Εθνικούς φορείς σε συγκεκριμένο λογ/σμό της Επιτροπής Ερευνών
1998–1999	Προσαρμογή του προγράμματος σπουδών του Τμήματος Φαρμακευτικής ΑΠΘ στις νεώτερες διεθνείς εξελίξεις στο χώρο των φαρμακευτικών επιστημών.
1997–2023	Πληρωμή μελών ΔΕΠ ΑΠΘ για αξιολογήσεις και λοιπές υπηρεσίες - Ν. 2530/97 (ΓΓΕΤ )
1997–2025	Πληρωμές μελών ΔΕΠ
1995–1999	Ανάπτυξη ανασυνδυασμένων πρωτεϊνών και διαγνωστικών.

Coordinator
2023–2025	Development of innovative exosome-based systems for the targeted delivery of drugs and nucleic acid therapeutics
2022–2025	Exploitation of pharmacogenomics methodologies in developing PBPK models of innovative doxorubicin formulations
2022–2023	Research team iGEM MetaThess 2022
2022–2027	Exploitation of research project data
2022–2022	Registration of Research Team "iGEM MetaThess" in the iGEM Competition
2022–2023	4th Panhellenic scientific conference of pharmacy students
2022–2023	4th panhellenic scientific conference of pharmacy students
2022–2023	Convention: "4th Panhellenic Scientific conference of Pharmacy students"
2022–2022	Award from the Next Stage Challenge Competition for the undergraduate students of iGEM Thessaloniki 2021 team
2021–2023	4th Panhellenic Conference of Pharmacy Students
2021–2023	iGEM Thessaloniki
2021–2024	Excelence in Teaching International Award, ''Simcyp Academic Awards 2021'' International Simcyp Consortium
2021–2027	Implementation of innovative methodologies into educational and research activities
2021–2025	Continuing Pharmaceutical Education for Community Pharmacists
2021–2023	Pharmacological assessment of new molecules in cancer cell lines
2021–2021	Registration of Research Team in the International Synthetic Biology Competition ''iGEM''
2019–2021	Investigation of the molecular function of miR-16-5p in ribosome biogenesis and its potential pharmacological exploitation in cancer
2019–2020	Simcyp Academic Awards 2019 - Most Effective Teachong Application
2018–2019	3rd Panhellenic Scientific conference of Pharmacy Students
2018–2019	3rd Panhellenic Scientific conference of Pharmacy Students
2018–2019	3rd Panhellenic Scientific conference of Pharmacy Students
2018–2019	Financial support for the participation of the academic team representing the AUTh in the iGEM 2018 competition
2018–2020	Convention: "3rd Panhellenic Scientific conference of Pharmacy Students"
2018–2022	i Gem Thessaloniki
2018–2020	Analysis of molecular signatures from three-dimensional cell cultures and circulating tumor cells in cancer therapy
2017–2019	Systematic pharmacological analysis of the expression of ribosomal protein genes
2017–2017	iGEM Greece 2017
2016–2018	Exploitation of molecular data of circulating tumor cells in cancer therapy
2012–2013	Clinical assessment of gene expression molecular signatures suffering hematopoieisis disorders
2012–2013	Assessemnt of ribosomal protein RPS5 and RPL35a in MEL cell erythroid differentiation with potential clinical relevance in myelodysplastic syndromes