PHARMACEUTICAL CHEMISTRY (ORGANOMETALLICS AND HORMONES)
| Title | ΦΑΡΜΑΚΕΥΤΙΚΗ ΧΗΜΕΙΑ (ΟΡΓΑΝΟΜΕΤΑΛΛΙΚΩΝ ΕΝΩΣΕΩΝ & ΟΡΜΟΝΩΝ) / PHARMACEUTICAL CHEMISTRY (ORGANOMETALLICS AND HORMONES) |
| Code | 34 |
| Faculty | Health Sciences |
| School | Pharmacy |
| Cycle / Level | 1st / Undergraduate |
| Teaching Period | Spring |
| Common | No |
| Status | Active |
| Course ID | 180000110 |
| Academic Year | 2017 – 2018 |
| Class Period | Spring |
| Faculty Instructors | |
| Weekly Hours | 5 |
| Class ID | 600114422
|
Class Schedule
| Building | Φυσικομαθηματική (Δ) |
| Floor | Υπόγειο 1 |
| Hall | ΑΙΘΟΥΣΑ Δ12 (184) |
| Calendar | Τρίτη 11:00 έως 13:00 |
Course Type 2016-2020
- Scientific Area
Course Type 2011-2015
Specific Foundation / Core
Mode of Delivery
- Face to face
Digital Course Content
- e-Study Guide https://qa.auth.gr/en/class/1/600114422
- At the Website of the School: users.auth.gr/papagd/Organometallika
Language of Instruction
- Greek (Instruction, Examination)
Prerequisites
General Prerequisites
Basic knowledge of organic and inorganic chemistry are required.
Learning Outcomes
Upon successful completion of this course, the student will learn from the perspective of medicinal chemistry about how metals interact with the biological systems, how to apply chelation therapy against metal intoxication, how platinum anticancer and gold antirheumatic drugs are synthesized and work. Also they will learn about the properties (physical and biological) and general applications of MRI contrast agents and diagnostic radiopharmaceuticals.At the same time students will learn from the perspective of medicinal chemistry about the role of hormone from chemical , biological and therapeutical point of view. Also they will learn the strategy for the design, synthesis and structure-activity relationships of synthetic analogs of hormones.
General Competences
- Apply knowledge in practice
- Work autonomously
- Work in teams
- Work in an interdisciplinary team
- Advance free, creative and causative thinking
Course Content (Syllabus)
Introduction to hormones. Classification of hormones and their studies from chemical, biological and therapeutical points of view. Design, synthesis, qualitative and quantitative evaluation of hormones, structure-activity relationships. Antagonist of hormones. Metabolism and mechanism of action. Role in the organism . Hormones as contraceptives. Insulin, calcitonin, hormones of hypophysis and hypothalamus.Role of hormones and metals in the biological systems. Introduction to coordination compounds. Metal compounds in the biological systems. Application of metal ligands in chelation therapy. Osteoporosis: design, synthesis and structure-activity relationships of biphosphonates.Platinum anticancer compounds, gold anti-rheumatic compounds(design, synthesis and structure-activity relationship). Metal compounds as diagnostics: Principles of design. MRI contrast agents, radiopharmaceuticals.
Educational Material Types
- Notes
- Slide presentations
- Book
Use of Information and Communication Technologies
Use of ICT
- Use of ICT in Course Teaching
- Use of ICT in Communication with Students
Course Organization
| Activities | Workload | ECTS | Individual | Teamwork | Erasmus |
|---|---|---|---|---|---|
| Lectures | 39 | 1.3 | ✓ | ||
| Laboratory Work | 12 | 0.4 | ✓ | ||
| Total | 51 | 1.7 |
Student Assessment
Description
Student assessment is done by midterm exams (optional) or by written exam at the end of the semester for the course and by a written test of laboratory practice.
Student Assessment methods
- Written Exam with Short Answer Questions (Summative)
Bibliography
Course Bibliography (Eudoxus)
Α. Γερονικάκη. «Οργανική Φαρμακευτική Χημεία . Ορμόνες». 3η έκδοση 2006.
A. Geronikaki" Organic Pharmaceutical Chemistry. Hormones" 5th edition. 2013.
Additional bibliography for study
E. Chiotellis, D. Papagiannopoulou, «Chapters on Bioinogranic Pharmaceutical Chemistry» (in greek)
Laboratory Experiment Notes, D. Papagiannopoulou (in greek) (users.auth.gr/papagd/Organometallika.)
Last Update
14-06-2013
