Learning Outcomes
After successful completion of this module, students will be able:
• To understand the genetics of mutations.
• Define basic concepts that fall under both classical and molecular genetics.
• To appreciate the importance of heredity in health and the relationship with the environment.
• Utilize modern biocompatibility control tools for biomaterials.
• To assess the side effects of drugs and their molecular pathway.
• To understand the pathophysiology and genetic-molecular background of various types of cancer in humans.
• To define basic concepts of congenital anomalies and to appreciate the proportion of sex, environment and other factors.
• Assess the risk of repeated miscarriages and their relationship with the environment.
Course Content (Syllabus)
1. INTRODUCTION TO THE GENETICS OF MUTATIONS
2. FROM CLASSICAL TO MOLECULAR GENETICS
3. AUTOSOMIC DOMINANCE AND REMIDUAL INHERITANCE, SEX-LINKED INHERITANCE, RACIAL DIFFERENTIATION DISORDERS
4. MODERN HISTOTECHNOLOGICAL TOOLS FOR CHECKING VIOLENCE BIOCOMPATIBILITY
5. ADVERSE EFFECTS OF DRUGS ON THE ORAL MUCOSA
6. CANCER STEM CELLS IN ORAL CANCER
7. EPIDEMIOLOGY OF CANCER
8. TISSUE REGENERATION AND THE ROLE OF THE ENVIRONMENT
9. ENVIRONMENTAL FACTORS AND BREAST CANCER
10. ADVERSE EFFECTS OF DRUGS ON THE ORAL MUCOSA
11. CONGENITAL ANOMALIES AND SEX RATIO
12. EFFECT OF GENETIC AND ENVIRONMENTAL FACTORS ON CRANIOFACIAL DEFORMATION AND GROWTH
13. PREGNANCY LOSS AND ENVIRONMENT
Additional bibliography for study
1. https://elearning.auth.gr/course/view.php?id=12002
2. Advanced in Vitro ExperimentalModels for Tissue Engineering-based Reconstruction of a 3D Dentin/pulp Complex: a Literature Review
3. Advances in organ-on-a-chip engineering
4. Ανεπιθύμητες Δράσεις Φαρμάκων και Εκδηλώσεις στη Στοματική Κοιλότητα
5. DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology, 10th Edition, 2014.
6. UCLA Fielding School of Public Health, Epidemiology of cancer, presentation by prof. Zhang Zuo-Feng, 2009, availabe at: https://ph.ucla.edu/
7. Διαπανεπιστημιακή Ομάδα Παθολόγων Ογκολόγων Ελλάδας. Εισαγωγή στην Κλινική Ογκολογία. Β’ Έκδοση, 2009.
8. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019 Jan;69(1):7-34. Jan 8.
9. Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, et al. (Eds.). AJCC Cancer Staging Manual (8th edition). Springer International Publishing: American Joint Commission on Cancer; 2017