Pharmacogenomics
| Title | Φαρμακογονιδιωματική / Pharmacogenomics |
| Code | ΙΑΑ04 |
| Faculty | Health Sciences |
| School | Medicine |
| Cycle / Level | 2nd / Postgraduate |
| Teaching Period | Winter |
| Coordinator | Ioannis Vizirianakis |
| Common | No |
| Status | Active |
| Course ID | 600019982 |
Programme of Study: DtPMS Iatrikī Akriveías - Metafrastikī Éreuna kai THerapeutikī (2025-méchri sīmera)
Registered students: 0
| Orientation | Attendance Type | Semester | Year | ECTS |
|---|---|---|---|---|
| KORMOS | Compulsory Course | 1 | 1 | 5 |
Programme of Study: PPS Precision Medicine-Translational Research and Therapeutics
Registered students: 25
| Orientation | Attendance Type | Semester | Year | ECTS |
|---|---|---|---|---|
| Core | Compulsory Course | 1 | 1 | 5 |
| Academic Year | 2024 – 2025 |
| Class Period | Winter |
| Faculty Instructors |
|
| Instructors from Other Categories |
|
| Weekly Hours | 3 |
| Class ID | 600261846
|
Course Type 2021
Specific Foundation
Mode of Delivery
- Face to face
- Distance learning
Digital Course Content
- e-Study Guide https://qa.auth.gr/en/class/1/600261846
Language of Instruction
- Greek (Instruction, Examination)
Prerequisites
General Prerequisites
Basic knowledge pharmacodynamics, pharmacokinetics, molecular biology, physiology
Learning Outcomes
Upon completion of the course, the students will be able to better understand the drug effects in the organism at the molecular level by focusing on: 1) the analysis of patient response heterogeneity issues seen in drug delivery; 2) correlations and implementation in clinical practice of specific pharmacogenomic biomarkers with pharmacological effects, thus improving the drug prescription outcome; 3) assessing the effects of drug metabolizing enzymes and transporters in the pharmacokinetic processes of drugs administered in the body; and 4) developing skills on Systems Pharmacology and Quantitative Pharmacology to advance their predictive capacity in pharmacotherapy issues related to drugs safety and efficiency/efficacy.
General Competences
- Apply knowledge in practice
- Retrieve, analyse and synthesise data and information, with the use of necessary technologies
- Make decisions
- Work in teams
- Work in an interdisciplinary team
- Generate new research ideas
Course Content (Syllabus)
The evolution of pharmacogenetics into pharmacogenomics in modern pharmacology. Genomic technologies and pharmacological drug development. Experimental methodologies for clinical utilization of pharmacogenomic data. Genetic polymorphism of metabolic enzymes and drug transporters. Differential pharmacological response in clinical practice. Pharmacogenomic approach to enhance drug safety in clinical practice. Pharmacogenomic databases. Pharmacogenomics of anticancer drugs. Pharmacogenomics and cardiotoxicity. Drug hepatotoxicity and pharmacogenomics. Drug prescription and pharmacogenomic data.
Keywords
pharmacogenomics, drug toxicity, adverse drug reactions, drug prescription, molecular biomarkers
Educational Material Types
- Slide presentations
- Multimedia
- Interactive excersises
- Book
Use of Information and Communication Technologies
Use of ICT
- Use of ICT in Course Teaching
- Use of ICT in Laboratory Teaching
- Use of ICT in Student Assessment
Description
Simcyp population pharmacokinetics simulator (https://www.certara.com/software/simcyp-pbpk/).
Our educational curriculum developed through the use of the platform win the award "The Most Effective Teaching Application" twice, in 2019 and 2021, during the "2019 και 2021 Simcyp Academic Awards" in UK (https://www.certara.com/simcyp-academic-awards-grant-and-partnership-scheme/).
Course Organization
| Activities | Workload | ECTS | Individual | Teamwork | Erasmus |
|---|---|---|---|---|---|
| Lectures | 35 | ✓ | |||
| Reading Assigment | 30 | ||||
| Written assigments | 59 | ✓ | |||
| Exams | 1 | ||||
| Total | 125 |
Student Assessment
Description
Assays in person, Quizzes, presentations, written exams
Student Assessment methods
- Written Exam with Multiple Choice Questions (Formative)
- Written Exam with Short Answer Questions (Formative)
- Written Assignment (Summative)
- Oral Exams (Summative)
- Performance / Staging (Summative)
- Written Exam with Problem Solving (Formative)
Bibliography
Course Bibliography (Eudoxus)
Βιβλίο [94690214]: Εγχειρίδιο εξατομικευμένης ιατρικής, Συλλογικό έργο, Επιμ. ξένης έκδοσης Vizirianakis Ioannis, Επιμ. ελλην. έκδοσης Βιζιριανάκης Ιωάννης, Ελλην. έκδοση University Studio Press
Additional bibliography for study
Ερευνητικές εργασίες
Last Update
01-03-2024
