Analytical Medicinal Chemistry, Structural Elucidation of Pharmaceutical Compounds
| Title | Αναλυτική Φαρμακοχημεία και Διευκρίνιση Δομής Φαρμακευτικών Ενώσεων / Analytical Medicinal Chemistry, Structural Elucidation of Pharmaceutical Compounds |
| Code | ΠΜΣΦΧ-006 |
| Faculty | Health Sciences |
| School | Pharmacy |
| Cycle / Level | 2nd / Postgraduate |
| Teaching Period | Winter/Spring |
| Coordinator | Dionysia Papagiannopoulou |
| Common | No |
| Status | Active |
| Course ID | 600017257 |
Programme of Study: Master's Degree in the Medical Chemistry in Drug Development
Registered students: 0
| Orientation | Attendance Type | Semester | Year | ECTS |
|---|---|---|---|---|
| KORMOS | Compulsory Course | 2 | 1 | 10 |
| Academic Year | 2024 – 2025 |
| Class Period | Spring |
| Faculty Instructors | |
| Class ID | 600272094
|
Digital Course Content
- e-Study Guide https://qa.auth.gr/en/class/1/600272094
- Other: https://users.auth.gr/klitinas
Language of Instruction
- Greek (Instruction, Examination)
Learning Outcomes
After successful completion of this course, the students will be able to use the basic principles of spectroscopy, such as nuclear megnatic resonance (1D and 2D) as well as mass spectroscopy, for the structural characterization of organic medicinal molecules.
General Competences
- Retrieve, analyse and synthesise data and information, with the use of necessary technologies
- Work autonomously
- Respect natural environment
Course Content (Syllabus)
1. Vassilis Demopoulos
Introduction and theory of nuclear magnetic resonance (NMR) spectrometry. Modes of the NMR instruments. 1D 1H-NMR: absorption of the proton nucleus, its chemical shift shielding and deshielding, diamagnetic anisotropy and the corresponding positive and negative zones, spin-spin coupling (first-order and more complex patterns), protons on heteroatoms, chemical shift equivalent and magnetic equivalent protons, index of unsaturation of compounds. 13C-NMR: absorption of tetrahedral, trigonal and carbonyl carbons. Use of the MestReNova software to depict the NMR spectrum of compounds from FID inputs, and assignment of the absorptions to the structure of the analyzed compound.
2. Dionysia Papagiannopoulou
Two-dimensional NMR spectrometry: 1) Homonuclear correlation spectroscopy 1Η-1Η (COSY), 2) Heteronuclear single-quantum coherence experiment (HSQC) (e.g. 1Η-13C) and 3) Heteronuclear multiple-bond coherence experiment (HMBC) (e.g. 1Η-13C)
3. Konstantinos Litinas
MS spectrometry: Fundamentals. Methods of cleavage of organic compounds. Ion analysis techniques. Modern ionization techniques. Molecular mass determination. Tandem MS. Applications of MS spectrometry in chemical analysis, environment, biology, geology, etc.
Keywords
Structure elucidation of organic compounds by spectroscopic methods (MS, NMR)
Educational Material Types
- Slide presentations
Use of Information and Communication Technologies
Use of ICT
- Use of ICT in Course Teaching
- Use of ICT in Communication with Students
Course Organization
| Activities | Workload | ECTS | Individual | Teamwork | Erasmus |
|---|---|---|---|---|---|
| Lectures | 175 | 7 | ✓ | ||
| Laboratory Work | 75 | 3 | ✓ | ||
| Total | 250 | 10 |
Student Assessment
Description
Written examination, and/or presentation of homework (bibliographic or solution of composite problems), at the end of the semester. The written examination process is based on questions that students are asked to answer based on both the knowledge they have gained from teaching and study, as well as the critical thinking and the ability to combine knowledge and information. The examination time is 3 hours. The examinations at the end of the semester are done on the dates, times and places announced by the Department.
Student Assessment methods
- Written Exam with Short Answer Questions (Summative)
- Written Exam with Extended Answer Questions (Summative)
- Written Exam with Problem Solving (Summative)
Bibliography
Additional bibliography for study
1) R.M Silverstain et al, “Spectrometric Identification of Organic Compounds”, John Wiley & Sons, Inc., 2005, ISBN: 0-471-39362-2.
2) R. S. Macomber, “A Complete introduction of Modern NMR Spectroscopy”, John Wiley & Sons, Inc., 1998, ISBN: 0-471-15736-8.
3) M. Hesse et al, “Spectroscopic Methods in Organic Chemistry”, Thieme, 2007, ISBN: 9783131060426.
Last Update
20-01-2022
