Course Content (Syllabus)
1)Demopoulos V. a) Stereochemical effects influencing biological activity (the role of optical, geometrical isomerization in the biological activity,the role of conformation, isosteres, isosterism. 2) Geronikaki A. Introduction to hormones.Synthesis , quanlitative and quantitative control, structure-activity relationships of corticosteroids Antagonist of hormones. Metabolism and mechanism of action. Role in the organism . The same for vitamines with antioxidant activity (ascorbic acid and tocoferoles). 3)Hadjipavlou-Litina D. Drug design, synthetic strategy, isolation, analysis, structures identification, molecular mechanism of action, structure activity relationships, selectivity, pharmacochemical aspects for representatitive drugs eg cholinergics, adrenergics, inhibitors of acetylcholinesterase. 4) Rekka E. This course briefly analyses synthetic routes, physical, chemical, biological properties, molecular mechanism of action, therapeutic applications of selected drugs acting on the central nervous system (general anesthetics, anxiolytics, antidepressants, opioid analgesics).
5) Papagiannopoulou D. Properties of diagnostic and therapeutic radionuclides. Methods of preparation and properties of the most common radiopharmaceuticals for the imaging of brain, myocardial, renal perfusion, as well as of targeted radiopharmaceuticals for bone, thyroid and cancer imaging/therapy are discussed.
Examination of the course (grade ≥5 ) by a final written examination at the end of the semester. Τhe evaluation process is based on questions that the students are asked to answer based on their knowledge obtained from the lectures as well as on the critical thinking and ability to combine, evaluate and handle the acquired knowledge and information.
The duration of the examination is 3 hours.
The examination at the end of the semester is performed at dates, time and place arranged by the department.
During the laboratory work, students hand over a report of their results and are evaluated. At the end of the laboratory work, there is a written examination on this. Successful termination of the laboratory course permits their participation to the final examination.
At the examination of the course, each tutor gives out separate exam forms.
To compute the final grade, the grade given by each tutor is weighted proportionately to the number of hours he/she has taught.
Final grade is calculated by addition of the course exam grade (90%) and the lab exam grade (10%).
Example: Supposing a course, where 60% of the hours are taught by tutor A and 40% by tutor B, the final grade is calculated by the following formula:
F.G.= 0.9(a+b) +0.1c,
Where, a the grade given by tutor A (in a scale of 0-6), b the grade given by tutor B (in a scale of 0-4), c the lab exam grade.